Protein Alignment dib and CYP27A1

DIOPT Version :10

• Sequence 1: NP_524810.2
• Gene: dib / 45282
• FlyBaseID: FBgn0000449
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_000775.1
• Gene: CYP27A1 / 1593
• HGNCID: 2605
• Length: 531
• Species: Homo sapiens
• Alignment Length: 462
• Identity: 125/462 - (27%)
• Similarity: 213/462 - (46%)
• Gaps: 48/462 - (10%)

  Fly    49 LRLHQAGQDKYE-KYGAIVRETIVPGQDIVWLYDPKDIALLLNERDCPQRRSHLALAQYRKSRPD 112
            |:|||. |..|: |||.:....:.|...:.....|....::..|...|. |:.:.|.:..:.:.|
Human    79 LQLHQL-QVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPV-RNDMELWKEHRDQHD 141

  Fly   113 VYKTTGLLPTNGPEWWRIRAQVQKELSAPKSVRNFVRQVDGVTKEFIRFLQ----ESRNGGAI-D 172
            :  |.|...|.|..|:::|..:.:.|..|.....:....:.|..:|:..|.    ||.:|..: |
Human   142 L--TYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSD 204

  Fly   173 MLPKLTRLNLELTCLLTFGAR---LQSFTAQEQDPRSRSTRLMDAAETTNSCILPTDQGLQLWRF 234
            |........||..|.:.|..|   ||....::.....||..|| ...:..:..||.      |..
Human   205 MAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLM-FQNSLYATFLPK------WTR 262

  Fly   235 LETPSFRKLSQAQSYMESVALELVEENVR-----------NGSVGSSLISAYVKNPELDRSDVVG 288
            ...|.:::.....:.:.|...:|::|.:.           :|...|..:...:.:.:|...:.:|
Human   263 PVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMG 327

  Fly   289 TAADLLLAGIDTTSYASAFLLYHIARNPEVQQKLHEEARRVLPSA-----KDELSMDALRTDITY 348
            :..:||:||:||||....:.|||::::||:|:.||||...|:|:.     ||...|..|
Human   328 SLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLL------ 386

  Fly   349 TRAVLKESLRLNPIAVGVGRILNQDAIFSGYFVPKGTTVVTQNMVACRLEQHFQDPLRFQPDRWL 413
             :|||||:|||.|:.....||:.::....|:..||.|..|..:.|..|....|.:|..|||.|||
Human   387 -KAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWL 450

  Fly   414 QHRSAL-----NPYLVLPFGHGMRACIARRLAEQNMHILLLRLLREYELIWSGSDDEMGVKTLLI 473
            ::....     :|:..:|||:|:|||:.||:||..|.:||.||:::|:::.:....|:.....::
Human   451 RNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIV 515

  Fly   474 NKPDAPV 480
            ..|:..|
Human   516 LVPNKKV 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dib	NP_524810.2	CYP24A1-like	59..480	CDD:410677	119/450 (26%)
CYP27A1	NP_000775.1	cytochrome_P450	89..524	CDD:477761	119/451 (26%)
		Sterol-binding. /evidence=ECO:0000255	384..398		9/20 (45%)