Protein Alignment dib and CYP27A1

DIOPT Version :9

• Sequence 1: NP_524810.2
• Gene: dib / 45282
• FlyBaseID: FBgn0000449
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_000775.1
• Gene: CYP27A1 / 1593
• HGNCID: 2605
• Length: 531
• Species: Homo sapiens
• Alignment Length: 462
• Identity: 125/462 - (27%)
• Similarity: 213/462 - (46%)
• Gaps: 48/462 - (10%)

  Fly    49 LRLHQAGQDKYE-KYGAIVRETIVPGQDIVWLYDPKDIALLLNERDCPQRRSHLALAQYRKSRPD 112
            |:|||. |..|: |||.:....:.|...:.....|....::..|...|. |:.:.|.:..:.:.|
Human    79 LQLHQL-QVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPV-RNDMELWKEHRDQHD 141

  Fly   113 VYKTTGLLPTNGPEWWRIRAQVQKELSAPKSVRNFVRQVDGVTKEFIRFLQ----ESRNGGAI-D 172
            :  |.|...|.|..|:::|..:.:.|..|.....:....:.|..:|:..|.    ||.:|..: |
Human   142 L--TYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSD 204

  Fly   173 MLPKLTRLNLELTCLLTFGAR---LQSFTAQEQDPRSRSTRLMDAAETTNSCILPTDQGLQLWRF 234
            |........||..|.:.|..|   ||....::.....||..|| ...:..:..||.      |..
Human   205 MAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLM-FQNSLYATFLPK------WTR 262

  Fly   235 LETPSFRKLSQAQSYMESVALELVEENVR-----------NGSVGSSLISAYVKNPELDRSDVVG 288
            ...|.:::.....:.:.|...:|::|.:.           :|...|..:...:.:.:|...:.:|
Human   263 PVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMG 327

  Fly   289 TAADLLLAGIDTTSYASAFLLYHIARNPEVQQKLHEEARRVLPSA-----KDELSMDALRTDITY 348
            :..:||:||:||||....:.|||::::||:|:.||||...|:|:.     ||...|..|
Human   328 SLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLL------ 386

  Fly   349 TRAVLKESLRLNPIAVGVGRILNQDAIFSGYFVPKGTTVVTQNMVACRLEQHFQDPLRFQPDRWL 413
             :|||||:|||.|:.....||:.::....|:..||.|..|..:.|..|....|.:|..|||.|||
Human   387 -KAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWL 450

  Fly   414 QHRSAL-----NPYLVLPFGHGMRACIARRLAEQNMHILLLRLLREYELIWSGSDDEMGVKTLLI 473
            ::....     :|:..:|||:|:|||:.||:||..|.:||.||:::|:::.:....|:.....::
Human   451 RNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIV 515

  Fly   474 NKPDAPV 480
            ..|:..|
Human   516 LVPNKKV 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dib	NP_524810.2	p450	25..446	CDD:299894	117/426 (27%)
CYP27A1	NP_000775.1	p450	61..526	CDD:306555	125/462 (27%)
		Sterol-binding. /evidence=ECO:0000255	384..398		9/20 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820