Protein Alignment dib and CYP11B1

DIOPT Version :10

• Sequence 1: NP_524810.2
• Gene: dib / 45282
• FlyBaseID: FBgn0000449
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_000488.3
• Gene: CYP11B1 / 1584
• HGNCID: 2591
• Length: 503
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 132/494 - (26%)
• Similarity: 212/494 - (42%)
• Gaps: 65/494 - (13%)

  Fly    20 PYQAIPGPRGPFGMGNLYNYLPGIGSYSWLRLHQAGQDK-YEKYGAIVRETI----------VPG 73
            |::|:  ||.|   ||           .||||.|..::: ||.....|.:|.          :.|
Human    37 PFEAM--PRRP---GN-----------RWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGG 85

  Fly    74 QDIVWLYDPKDIALLLNERDC--PQRRSHLALAQYRKSRPDVYKTTGLLPTNGPEWWRIRAQVQK 136
            ..:|.:..|:|:. .|.:.|.  |.|.|......||:.|.   ...|:...|||||...|.::..
Human    86 AGMVCVMLPEDVE-KLQQVDSLHPHRMSLEPWVAYRQHRG---HKCGVFLLNGPEWRFNRLRLNP 146

  Fly   137 ELSAPKSVRNFVRQVDGVTKEFI-----RFLQESRNGGAIDMLPKLTRLNLELTCLLTFGARLQS 196
            |:.:|.:|:.|:..||.|.::|.     :.||.:|....:|:.|.:....:|.:.|..||.||
Human   147 EVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERL-- 209

  Fly   197 FTAQEQDPRSRSTRLMDAAE-----TTNSCILPTDQGLQLWRFLETPSFRK---------LSQAQ 247
             ......|.|.|...:.|.|     |.....:|  :.|..|   .:|...|         .....
Human   210 -GLVGHSPSSASLNFLHALEVMFKSTVQLMFMP--RSLSRW---TSPKVWKEHFEAWDCIFQYGD 268

  Fly   248 SYMESVALELVEENVRNGSVGSSLISAYVKNPELDRSDVVGTAADLLLAGIDTTSYASAFLLYHI 312
            :.::.:..||.....:.   .:|:::..:.|.||....:...:.:|....:|||.:.....|:.:
Human   269 NCIQKIYQELAFSRPQQ---YTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFEL 330

  Fly   313 ARNPEVQQKLHEEARRVLPSAKDELSMDALRTDITYTRAVLKESLRLNPIAVGVGRILNQDAIFS 377
            ||||.|||.|.:|:.....|..:.  .....|::...||.|||:|||.|:.:.:.|:.:.|.:..
Human   331 ARNPNVQQALRQESLAAAASISEH--PQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQ 393

  Fly   378 GYFVPKGTTVVTQNMVACRLEQHFQDPLRFQPDRWLQHRSALNPYLVLPFGHGMRACIARRLAEQ 442
            .|.:|.||.|........|....|..|.|:.|.|||..|.:...:..:|||.|||.|:.|||||.
Human   394 NYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEA 458

  Fly   443 NMHILLLRLLREYELIWSGSDDEMGVKTLLINKPDAPVL 481
            .|.:||..:|:..::.....:|...|.:.::.....|:|
Human   459 EMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLL 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dib	NP_524810.2	CYP24A1-like	59..480	CDD:410677	118/451 (26%)
CYP11B1	NP_000488.3	CYP11B	72..499	CDD:410737	116/443 (26%)