Protein Alignment dib and CYP2E1

DIOPT Version :10

• Sequence 1: NP_524810.2
• Gene: dib / 45282
• FlyBaseID: FBgn0000449
• Length: 489
• Species: Drosophila melanogaster
• Sequence 2: NP_000764.1
• Gene: CYP2E1 / 1571
• HGNCID: 2631
• Length: 493
• Species: Homo sapiens
• Alignment Length: 488
• Identity: 122/488 - (25%)
• Similarity: 177/488 - (36%)
• Gaps: 117/488 - (23%)

  Fly    27 PRGPFGM---GNLYNY-LPGIGSYSWLRLHQAGQDKYEKYGAIVRETIVPGQDIV--WLYDPKDI 85
            |.|||.:   |||:.. |..|.. |:.||.|.....:..|....|..::.|...|  .|.|.||
Human    33 PPGPFPLPIIGNLFQLELKNIPK-SFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKD- 95

  Fly    86 ALLLNERDCPQRRSHLALAQYRKSRPDVYKTTGLLPTNGPEWWRIRAQVQKELSAPKSVRNFVRQ 150
             ......|.|...:|              :..|::..|||.|              |.:|.|
Human    96 -EFSGRGDLPAFHAH--------------RDRGIIFNNGPTW--------------KDIRRF--- 128

  Fly   151 VDGVTKEFIRFLQESRNGGAIDMLPKLTRLNLELTCLLTFGARLQSFTAQEQDPR---------- 205
                      .|...||.| :......:|:..|...||   ..|:....|..||.
Human   129 ----------SLTTLRNYG-MGKQGNESRIQREAHFLL---EALRKTQGQPFDPTFLIGCAPCNV 179

  Fly   206 --------------SRSTRLMDAAETTNSCILPTDQGLQLWRFLETPSF--------RKLSQAQS 248
                          .:..||| .....|..:|.| ..|||:.  ..|||        ||:.:..:
Human   180 IADILFRKHFDYNDEKFLRLM-YLFNENFHLLST-PWLQLYN--NFPSFLHYLPGSHRKVIKNVA 240

  Fly   249 YMESVALELVEE-------NVRNGSVGSSLISAYVKNPELDR----SDVVGTAADLLLAGIDTTS 302
            .::....|.|:|       |.........|:....:....:|    ..:..|.|||..||.:|||
Human   241 EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTS 305

  Fly   303 YASAFLLYHIARNPEVQQKLHEEARRV-----LPSAKDELSMDALRTDITYTRAVLKESLR-LNP 361
            ....:.|..:.:.||:::|||||..||     :|:.||       |.::.|..||:.|..| :..
Human   306 TTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKD-------RQEMPYMDAVVHEIQRFITL 363

  Fly   362 IAVGVGRILNQDAIFSGYFVPKGTTVVTQNMVACRLEQHFQDPLRFQPDRWLQHRSAL--NPYLV 424
            :...:.....:|.||.||.:||||.||..........|.|.||.:|:|:.:|......  :.|.
Human   364 VPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYF- 427

  Fly   425 LPFGHGMRACIARRLAEQNMHILLLRLLREYEL 457
            .||..|.|.|....||...:.:||..:|:.:.|
Human   428 KPFSTGKRVCAGEGLARMELFLLLCAILQHFNL 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dib	NP_524810.2	CYP24A1-like	59..480	CDD:410677	109/452 (24%)
CYP2E1	NP_000764.1	CYP2C-like	64..487	CDD:410758	109/456 (24%)