DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dib and Cyp27b1

DIOPT Version :9

Sequence 1:	NP_524810.2	Gene:	dib / 45282	FlyBaseID:	FBgn0000449	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_034139.2	Gene:	Cyp27b1 / 13115	MGIID:	1098274	Length:	507	Species:	Mus musculus

Alignment Length:	477	Identity:	129/477 - (27%)
Similarity:	207/477 - (43%)	Gaps:	68/477 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GPRGPFGMGNLYNYLPGIGSYSWL----------RLHQAGQDKYEKYGAI-------VRETIVPG 73
            |.||...:....:.:||..:.|:|          |||:.......:||.|       :|
Mouse    26 GSRGSESVLRSLSDIPGPSTLSFLAELFCKGGLSRLHELQVHGAARYGPIWSGSFGTLR------ 84

  Fly    74 QDIVWLYDPKDI-ALLLNERDCPQRRSHLALAQYRKSRPDVYKTTGLLPTNGPEWWRIRAQVQKE 137
              .|::.||..: .||..|..||:|.|..:.|::|:..   .:..|||..:|.||.|:|:.:...
Mouse    85 --TVYVADPTLVEQLLRQESHCPERCSFSSWAEHRRRH---QRACGLLTADGEEWQRLRSLLAPL 144

  Fly   138 LSAPKSVRNFVRQVDGVTKEFIRFLQESRNGGA------IDMLPKLTRLNLELTCLLTFGARLQS 196
            |..|::...:...:|.|.::.:|.|:..|..|:      :|:..:..:..||....:..|:||..
Mouse   145 LLRPQAAAGYAGTLDNVVRDLVRRLRRQRGRGSGLPGLVLDVAGEFYKFGLESIGAVLLGSRLGC 209

  Fly   197 FTAQEQDPRSRSTRLMDAAETTNSCILPTDQGLQLWRFLETPSFRKLSQAQSYMESVALELVEEN 261
            ..|:.  |....|.:........|.:|.......|...:..| :.:|.:....|.:.|...||
Mouse   210 LEAEV--PPDTETFIHAVGSVFVSTLLTMAMPNWLHHLIPGP-WARLCRDWDQMFAFAQRHVE-- 269

  Fly   262 VRNGSVGSSLISAYVKN---PELDR-----------------SDVVGTAADLLLAGIDTTSYASA 306
            :|.|       .|.::|   ||.|.                 ..:||...:|||||:||.|...:
Mouse   270 LREG-------EAAMRNQGKPEEDMPSGHHLTHFLFREKVSVQSIVGNVTELLLAGVDTVSNTLS 327

  Fly   307 FLLYHIARNPEVQQKLHEEARRVLPSAKDELSMDALRTDITYTRAVLKESLRLNPIAVGVGRILN 371
            :.||.::|:|:||..||.|.......:.......|| :.:...:||:||.|||.|:..|..|:.:
Mouse   328 WTLYELSRHPDVQTALHSEITAGTRGSCAHPHGTAL-SQLPLLKAVIKEVLRLYPVVPGNSRVPD 391

  Fly   372 QDAIFSGYFVPKGTTVVTQNMVACRLEQHFQDPLRFQPDRWLQHRSALNPYLVLPFGHGMRACIA 436
            :|.....|.:|:.|.|...:....|....|.||..|.|.|||......:|:..||||.|.|:||.
Mouse   392 RDIRVGNYVIPQDTLVSLCHYATSRDPTQFPDPNSFNPARWLGEGPTPHPFASLPFGFGKRSCIG 456

  Fly   437 RRLAEQNMHILLLRLLREYELI 458
            |||||..:.:.|.::|..:|::
Mouse   457 RRLAELELQMALSQILTHFEVL 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dib	NP_524810.2	p450	25..446	CDD:299894	126/463 (27%)
Cyp27b1	NP_034139.2	p450	41..504	CDD:278495	126/462 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820