DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dib and Cyp24a1

DIOPT Version :9

Sequence 1:	NP_524810.2	Gene:	dib / 45282	FlyBaseID:	FBgn0000449	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_034126.1	Gene:	Cyp24a1 / 13081	MGIID:	88593	Length:	514	Species:	Mus musculus

Alignment Length:	482	Identity:	132/482 - (27%)
Similarity:	232/482 - (48%)	Gaps:	53/482 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AIPGPRGPFGMGNLYNYLPGIGSYSW----LRLHQAGQDKYEKYGAIVRETIVPGQ-DIVWLYDP 82
            ::|||.....:|:|....       |    .:.|....:.::|||.|.|..:  |. |.|.|..|
Mouse    57 SLPGPTNWPLLGSLLEIF-------WKGGLKKQHDTLAEYHKKYGQIFRMKL--GSFDSVHLGSP 112

  Fly    83 KDI-ALLLNERDCPQRRSHLALAQYRKSRPDVYKTTGLLPTNGPEWWRIRAQVQKELSAPKSVRN 146
            ..: ||...|...|||........||..|.:.|   ||:...|.||.|:|:..||:|..|..:..
Mouse   113 SLLEALYRTESAHPQRLEIKPWKAYRDHRNEAY---GLMILEGQEWQRVRSAFQKKLMKPVEIMK 174

  Fly   147 FVRQVDGVTKEFIRFLQESRN--GGAIDMLPKLTRLNLELTCLLTFGARLQSFTAQEQDPRSRST 209
            ..::::.|..:|:..:.|.|:  |...|:..:|.:.:.|..||:.:..|   |...::|....:.
Mouse   175 LDKKINEVLADFMGQIDELRDERGRIQDLYSELNKWSFESICLVLYEKR---FGLLQKDTEEEAL 236

  Fly   210 RLMDAAETTNS-----CILPTDQGLQLWRFLETPSFRKLSQAQSYMESVALELVEENVR------ 263
            ..:.|.:|..|     .:.|    ::|.:.|.|    |:.||    .::|.:.:.::|:
Mouse   237 TFIAAIKTMMSTFGKMMVTP----VELHKRLNT----KVWQA----HTLAWDTIFKSVKPCIDHR 289

  Fly   264 ----NGSVGSSLISAYVKNPELDRSDVVGTAADLLLAGIDTTSYASAFLLYHIARNPEVQQKLHE 324
                :...|:..:....:...|.:.::.....:|.||.::||:.:..::||:::|||:|||:|..
Mouse   290 LERYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQRLLR 354

  Fly   325 EARRVLPSAKDELSMDALRTDITYTRAVLKESLRLNPIAVGVGRILNQDAIFSGYFVPKGTTVVT 389
            |.:.|||..:...:.|.  .::.|.:|.||||:||.|......|.|::..:...|.:||||.:..
Mouse   355 EIQSVLPDNQTPRAEDV--RNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYTLPKGTVLTL 417

  Fly   390 QNMVACRLEQHFQDPLRFQPDRWLQHRSALNPYLVLPFGHGMRACIARRLAEQNMHILLLRLLRE 454
            ...|....|.:|:|..:|:|:|||:....:||:..||||.|.|.||.|||||..:|:.|..::::
Mouse   418 NTQVLGSSEDNFEDADKFRPERWLEKEKKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIIQK 482

  Fly   455 YELIWSGSDD-EMGVKTLLINKPDAPV 480
            |.::.:.|:. ||....:|:...:.|:
Mouse   483 YNIVATDSEPVEMLHLGILVPSRELPI 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dib	NP_524810.2	p450	25..446	CDD:299894	124/443 (28%)
Cyp24a1	NP_034126.1	p450	59..513	CDD:278495	132/480 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4812
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.770