DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dib and Cyp11b1

DIOPT Version :9

Sequence 1:	NP_524810.2	Gene:	dib / 45282	FlyBaseID:	FBgn0000449	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_001028401.2	Gene:	Cyp11b1 / 110115	MGIID:	88583	Length:	501	Species:	Mus musculus

Alignment Length:	521	Identity:	141/521 - (27%)
Similarity:	229/521 - (43%)	Gaps:	89/521 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AKPYQAIPGPRGPFGMGNLYNYLP-------GIGSYS---WLR----LHQAGQDK--------YE 60
            |:|:|.:...|   .:|......|       .|..||   ||:    |.:.||:.        :.
Mouse    14 ARPWQCLHRTR---ALGTTATLAPKTLQPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQVFR 75

  Fly    61 KYGAIVRETIVPGQDIVWLYDPKDIALLLN-ERDCPQRRSHLALAQYRKSRPDVYKTTGLLPTNG 124
            :.|.|.|.::...| ||::..|:|:..|.. |...|.|....:...:|:.|.   ...|:...||
Mouse    76 ELGPIFRHSVGKTQ-IVFVTLPEDVEKLYQVESTHPCRMPLESWIVHRELRG---LGRGVFLLNG 136

  Fly   125 PEWWRIRAQVQKELSAPKSVRNFVRQVDGVTKEFIRFLQ----ESRNGG-AIDMLPKLTRLNLEL 184
            |||:..|.|:...:.:||:|:.||..|||:.::|:..|:    ||.:|. ::|....:....:|.
Mouse   137 PEWYFNRLQLNPNVLSPKAVQKFVPLVDGIARDFVDNLKKKMLESVHGSFSMDFQSSVFNYTIEA 201

  Fly   185 TCLLTFGARLQSFTAQEQDPRSRS--TRLMDAAETTNSCI-LPTD-----------QGLQLWRFL 235
            :..:.||.|| ....::..|.|..  ..|....:||...: ||..           :.|:.|.|:
Mouse   202 SHFVLFGERL-GLIGRDLSPDSLKFLHTLHSMFKTTTQLLYLPRSLTRWTSTRVWKENLESWDFI 265

  Fly   236 E-------TPSFRKLSQAQSYMESVALELVEENVRNGSVGSSLISAYVKNPELDRSDVVGTAADL 293
            .       ...:|:|::.:....||..|||.|..                  |....:...:.:|
Mouse   266 SEYVTKCIKNVYRELAEGRPQSWSVTAELVAERT------------------LSMDAIQANSMEL 312

  Fly   294 LLAGIDTTSYASAFLLYHIARNPEVQQKLHEE--ARRVLPSAKDELSMDALRTDITYTRAVLKES 356
            :....||||.......:.:||||:|||.|.:|  |.....:|..:.:|    :|:...||.|||:
Mouse   313 IAGSTDTTSTPLVMTFFELARNPDVQQALRQESLAAEASIAANPQKAM----SDLPLLRAALKET 373

  Fly   357 LRLNPIAVGVGRILNQDAIFSGYFVPKGTTVVTQNMVAC-RLEQHFQDPLRFQPDRWLQHRSALN 420
            |||.|:...:.|||:.|.:...|.||.| ||:..|:.:. |....|..|.|:.|.|||:.:.:
Mouse   374 LRLYPVGTFLERILSSDLVLQNYHVPAG-TVLNVNLYSMGRNPAVFPRPERYMPQRWLERKRS-- 435

  Fly   421 PYLVLPFGHGMRACIARRLAEQNMHILLLRLLREYELIWSGSDD-EMGVKTLLINKPDAPVLIDL 484
             :..|.||.|:|.|:.|||||..|.:||..:|:.:.:.....:| .|..:.:|:  |.:..|:..
Mouse   436 -FKHLAFGFGVRQCLGRRLAEAEMMLLLHHVLKSFHVETQEKEDVRMAYRFVLM--PSSSPLLTF 497

  Fly   485 R 485
            |
Mouse   498 R 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dib	NP_524810.2	p450	25..446	CDD:299894	129/472 (27%)
Cyp11b1	NP_001028401.2	p450	44..497	CDD:278495	133/485 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820