DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-2 and FCGBP

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_003881.2	Gene:	FCGBP / 8857	HGNCID:	13572	Length:	5405	Species:	Homo sapiens

Alignment Length:	557	Identity:	149/557 - (26%)
Similarity:	224/557 - (40%)	Gaps:	105/557 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 GSEWNDPE-DPCKTYKCVATVVTETIQKCYSQCDNNQL-QPPRPGECCPTCQGCKINGQ-TVAEG 194
            |..|..|. ||....:|..:..|         |..::| |...||.|.|...|  ..|. |....
Human  1841 GGSWRAPGWDPLCWDECRGSCPT---------CPEDRLEQYEGPGFCGPLAPG--TGGPFTTCHA 1894

  Fly   195 HEVDASIDDRCLVCQCRG---TQLTCSKKTCPVLPCPMSKQI----KRPDECCPRCPQNHSFLPV 252
            |....|....|::..|.|   ..:.|......|..|..:..:    :....|...||:|..:...
Human  1895 HVPPESFFKGCVLDVCMGGGDRDILCKALASYVAACQAAGVVIEDWRAQVGCEITCPENSHYEVC 1959

  Fly   253 PGKCLFNKSVYPEKTQFMPDRCTNCTCLNGTSVCQRPTCPILECAPEF-QEPDGCCP---RCAVA 313
            ...|              |..|.:...|...:||:.|.....:|...| ...|.|.|   .|.
Human  1960 GSPC--------------PASCPSPAPLTTPAVCEGPCVEGCQCDAGFVLSADRCVPLNNGCG-- 2008

  Fly   314 EVRSECSLDGIVYQ-NNETWDMGPCRS-CRC--NGGTIRCAQMRCPAVKCRANEELKQPPGECC- 373
                 |..:|..:: .:|.|..|.|.. |||  .||::.|....|..             ||.|
Human  2009 -----CWANGTYHEAGSEFWADGTCSQWCRCGPGGGSLVCTPASCGL-------------GEVCG 2055

  Fly   374 ------QRC--VETAGTCTVFGDPHFRTFDGKFFSFQGSCKYLLASDCMG-----KTFHIRLTNE 425
                  ..|  |.|| .|..:||||:.|.||..|:|||:|:|||::.|.|     :.|.:.:.||
Human  2056 LLPSGQHGCQPVSTA-ECQAWGDPHYVTLDGHRFNFQGTCEYLLSAPCHGPPLGAENFTVTVANE 2119

  Fly   426 GRGTRRASWAKTVTLSLRNLKVNLGQR--MRVKVNGTRVTLPYFVVAGGQNVTIERLANGGAVML 488
            .||::..|:.::|||.:.|..:.|..|  .:::|:|..||||:.:     :..:....:|..|::
Human  2120 HRGSQAVSYTRSVTLQIYNHSLTLSARWPRKLQVDGVFVTLPFQL-----DSLLHAHLSGADVVV 2179

  Fly   489 RSEMGLTLEWNGAGFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTGKDGRSHGDDEVWHFANSWKV 553
            .:..||:|.::|..|:::.|||.:...|||||||:|....|||....|:..|          |:|
Human  2180 TTTSGLSLAFDGDSFVRLRVPAAYAGSLCGLCGNYNQDPADDLKAVGGKPAG----------WQV 2234

  Fly   554 GGPKSCSRKREFLAATPTCDKRKSNF----YCHPLS-VPALFGECNERLNPENYKAACRMDVCEC 613
            ||.:.|.........:|...:::.:|    .|..:| .......|:..:.|..|...|.:|.|:.
Human  2235 GGAQGCGECVSKPCPSPCTPEQQESFGGPDACGVISATDGPLAPCHGLVPPAQYFQGCLLDACQV 2299

  Fly   614 ---PSGDCHCDSFAAYAHECRRLGVQLPDWRSATNCP 647
               |.|  .|.:.|.|...|:..|.||.:||....||
Human  2300 QGHPGG--LCPAVATYVAACQAAGAQLREWRRPDFCP 2334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	11/66 (17%)
		VWC	256..310	CDD:278520	12/57 (21%)
		VWC	319..376	CDD:214564	16/67 (24%)
		VWD	371..536	CDD:214566	63/180 (35%)
		C8	580..646	CDD:285899	19/69 (28%)
FCGBP	NP_003881.2	IgGFc-binding	24..450
		VWD	472..627	CDD:278521
		C8	667..742	CDD:214843
		TIL	745..799	CDD:280072
		VWD	864..1019	CDD:278521
		C8	1060..1133	CDD:214843
		TIL	1136..1189	CDD:280072
		VWC	1194..1245	CDD:302663
		VWD	1252..1407	CDD:278521
		C8	1454..1529	CDD:214843
		TIL	1532..1585	CDD:280072
		VWC	1587..1640	CDD:302663
		VWD	1673..1832	CDD:278521
		C8	1871..1946	CDD:214843	16/76 (21%)
		TIL	1950..2004	CDD:280072	15/67 (22%)
		VWD	2072..2222	CDD:278521	55/154 (36%)
		C8	2260..2334	CDD:214843	20/75 (27%)
		TIL	2337..2390	CDD:280072
		VWC	2398..2446	CDD:302663
		VWD	2453..2608	CDD:278521
		C8	2655..2730	CDD:214843
		TIL	2733..2786	CDD:280072
		VWC	2788..2841	CDD:302663
		VWD	2874..3033	CDD:278521
		C8	3072..3147	CDD:214843
		TIL	3151..3205	CDD:280072
		VWD	3273..3423	CDD:278521
		C8	3461..3535	CDD:214843
		TIL	3538..3591	CDD:280072
		VWC	3599..3647	CDD:302663
		VWD	3654..3809	CDD:278521
		C8	3856..3931	CDD:214843
		TIL	3934..3987	CDD:280072
		VWC	3989..4042	CDD:302663
		VWD	4075..4234	CDD:278521
		C8	4273..4348	CDD:214843
		TIL	4352..4406	CDD:280072
		VWD	4474..4624	CDD:278521
		C8	4662..4736	CDD:214843
		TIL	4739..4792	CDD:280072
		VWC	4797..4849	CDD:302663
		VWD	4856..5003	CDD:278521
		C8	5044..5118	CDD:214843
		TIL	5121..5174	CDD:280072
		VWD	5235..5382	CDD:295339
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5817
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840