Protein Alignment cv-2 and ZAN

DIOPT Version :10

• Sequence 1: NP_524809.2
• Gene: cv-2 / 45280
• FlyBaseID: FBgn0000395
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_003377.2
• Gene: ZAN / 7455
• HGNCID: 12857
• Length: 2812
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 166/575 - (28%)
• Similarity: 235/575 - (40%)
• Gaps: 130/575 - (22%)

  Fly   127 GMSYESGSEW---NDPEDPCKTYKCVATVVTETIQKCYSQCDNN-QLQPPRPGECCPTCQGCKIN 187
            |...|.|:.|   .|.:..|:.|:.|.:          ..||:: |.....||.|
Human  1311 GDKEELGNSWQTDQDEDQECQKYQVVNS----------PSCDSSLQSSMSGPGFC---------- 1355

  Fly   188 GQTV-AEG-------HEVDASIDDRCLVCQC--RGTQ-LTCSKKTCPVLPCPMS----KQIKRPD 237
            |:.| ..|       |...||..|.|::..|  :|.| |.|:..:.....|..:    |..:.|.
Human  1356 GRLVDTHGPFETCLLHVKAASFFDSCMLDMCGFQGLQHLLCTHMSTMTTTCQDAGHAVKPWREPH 1420

  Fly   238 ECCPRCPQNHSF----LPVPGKCLFNKSVYPEKTQFMPDRCTN-CTC-----LNGTSVCQRPTCP 292
            .|...||.|..:    .|.|..|....|     ..|..|||.. |.|     |:|
Human  1421 FCPMACPPNSKYSLCAKPCPDTCHSGFS-----GMFCSDRCVEACECNPGFVLSG---------- 1470

  Fly   293 ILECAPEFQEPDGCCPRCAVAEVRSECSL---DGIVYQNNETWDMGPCRS-CRCNGGTIRCAQMR 353
             |||.|                 ||:|..   .|..::..|.|....|:. |.|....    ::|
Human  1471 -LECIP-----------------RSQCGCLHPAGSYFKVGERWYKPGCKELCVCESNN----RIR 1513

  Fly   354 CPAVKCRANEELKQPPGECCQRC-VETAGTCTVFGDPHFRTFDGKFFSFQGSCKYLLASDCMGKT 417
            |...:|||.|...|..|  ...| .:.|.|||..||||:.||||....|.|:|.|:|...|..::
Human  1514 CQPWRCRAQEFCGQQDG--IYGCHAQGAATCTASGDPHYLTFDGALHHFMGTCTYVLTRPCWSRS 1576

  Fly   418 ----FHIRLTNEGR-GTRRASWAKTVTLSLRNLKVNLGQRMRVKVNGTRVTLPYFVVAGGQNVTI 477
                |.:..|||.| |....|:.|.|.:::.:|.::|.:..:|.:||.||.||.::..|  .|||
Human  1577 QDSYFVVSATNENRGGILEVSYIKAVHVTVFDLSISLLRGCKVMLNGHRVALPVWLAQG--RVTI 1639

  Fly   478 ERLANGGAVMLRSEMGLTLEWNGAGFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTGKDGRSHGDD 542
            ...:|  .|:|.:..||.:.::|:..::|:||:.:..:|||||||:|.:|.||....|.:..||.
Human  1640 RLSSN--LVLLYTNFGLQVRYDGSHLVEVTVPSSYGGQLCGLCGNYNNNSLDDNLRPDRKLAGDS 1702

  Fly   543 EVWHFANSWK-----------VGG-PKSCSRKREFLAATPTCDKRKSNFYCHPLSVP-ALFGECN 594
              .....:||           ||| |.||..       ....|....|  |..|..| ..|.:|:
Human  1703 --MQLGAAWKLPESSEPGCFLVGGKPSSCQE-------NSMADAWNKN--CAILINPQGPFSQCH 1756

  Fly   595 ERLNPENYKAACRMDVCECPSGD--CHCDSFAAYAHECRRLGVQLPDWRSATNCP 647
            :.:.|::..|:|....|. ..||  ..|.|..|||..|.:.| |.|.||:.|.||
Human  1757 QVVPPQSSFASCVHGQCG-TKGDTTALCRSLQAYASLCAQAG-QAPAWRNRTFCP 1809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	17/73 (23%)
		VWC	256..310	CDD:278520	14/59 (24%)
		VWC	319..376	CDD:214564	15/60 (25%)
		VWD	371..536	CDD:214566	61/170 (36%)
		C8	580..646	CDD:462584	23/68 (34%)
ZAN	NP_003377.2	MAM	41..202	CDD:99706
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	61..84
		MAM	211..365	CDD:99706
		MAM	373..534	CDD:99706
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	545..884
		PspC_subgroup_2	<558..820	CDD:468202
		66 X heptapeptide repeats (approximate) (mucin-like domain)	573..1041
		Herpes_BLLF1	<838..>1028	CDD:282904
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	904..929
		TIL	1044..1093	CDD:410995
		TILa	1095..1148	CDD:432736
		VWD	1156..1308	CDD:459671
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1302..1323		4/11 (36%)
		C8	1349..1423	CDD:214843	19/83 (23%)
		TIL	1426..1479	CDD:410995	21/85 (25%)
		TILa	1481..1535	CDD:432736	14/59 (24%)
		VWD	1542..1695	CDD:459671	58/156 (37%)
		C8	1737..1809	CDD:214843	24/75 (32%)
		TIL	<1827..1867	CDD:410995
		TILa	1869..1924	CDD:432736
		VWD	1931..2084	CDD:459671
		C8	2140..2207	CDD:462584
		TIL	2211..2267	CDD:410995
		TILa	2269..2320	CDD:432736
		VWD	2331..2484	CDD:459671
		C8	2543..>2597	CDD:214843
		TILa	2654..2707	CDD:432736
		EGF	2712..2740	CDD:394967