DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cv-2 and Muc5b

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_083077.2	Gene:	Muc5b / 74180	MGIID:	1921430	Length:	4800	Species:	Mus musculus

Alignment Length:	734	Identity:	187/734 - (25%)
Similarity:	268/734 - (36%)	Gaps:	226/734 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GFRPSTQLLILIAVLLAL----------LQGRTVDAGAGD--SLSGV--------------RQSC 66
            |.:...||:.|:.|.:.|          |.|......|.|  :||||              :.||
Mouse   537 GLQLQVQLVPLMQVFVRLDRSYQGQMCGLCGNFNQNQADDFTALSGVVEGTGAAFSNTWKTQASC 601

  Fly    67 SNE--------GEEVQLKNQPQIFTCFKCECQNGFVNCRDTCPPV---NDCYILDKSNGTCCRRC 120
            .|.        ...|:.:|..:.:.....|....|..|..|..||   ::| :.|..|   |...
Mouse   602 PNSKNTYEDPCSYSVENENFAREWCSMLTESSGVFSACHATVSPVPFYSNC-LFDTCN---CENS 662

  Fly   121 KGCSFRGMS------YESG---SEWNDPEDPCKTYKCVATVVTETIQKCYSQCDNNQLQPPRPGE 176
            :.|....:|      ...|   |.|.|                   :.||...:|
Mouse   663 EDCMCAALSSYVFACAAKGVLLSGWRD-------------------KVCYKYTNN---------- 698

  Fly   177 CCPTCQGCKINGQTVAEGHEVDASIDDRCLVCQ--CRG---TQLTCSKK--TCPVLPCPMSKQIK 234
             ||         ||....:.|.:        ||  ||.   ..:|||..  |.....||....:.
Mouse   699 -CP---------QTKGYFYSVSS--------CQPTCRSLSEADVTCSVPFVTVDGCTCPEGTFLN 745

  Fly   235 RPDECCP--RCPQNHSFLPVPGKCLFNKSVYPEKTQFMPDRCTNCTCLNGTSVC-----QRPTCP 292
            ..|.|.|  .||           |.|:.:|...: :.:.|....|:|.||...|     |:.|
Mouse   746 DKDHCVPVEECP-----------CYFHGTVVAPR-EVVTDNGVVCSCTNGKLTCLGALMQKST-- 796

  Fly   293 ILECAPEFQEPDGCCPRCAVAEVRSECSLDGIVYQNNETWDMGPCRSCRC--------------N 343
              ||.......|  |...:|....:||      .::..|.|: .|.|.:|              |
Mouse   797 --ECQAPMVYLD--CNNASVGHHGAEC------LKSCHTLDV-ECFSTQCVSGCVCPSGLVADGN 850

  Fly   344 GGTIRCAQMRCPAVKCRANEELKQPPGEC----CQRCV-----------ETAGTCTVFGDPHFRT 393
            ||.|  |:..||.:    :.|:...|||.    |..|.           ...|.|..:||.||.|
Mouse   851 GGCI--AEEDCPCI----HNEVTYRPGEIIRVDCNNCTCKNRRWECTNKPCMGACVAYGDGHFVT 909

  Fly   394 FDGKFFSFQGSCKYLLASD-CMGK-----TFHIRLTNEGRGTRRASWAKTVTLSLRNLKVNLGQ- 451
            |||:.:.|:|||:|.||.| |.|.     ||.|...|...||...:.:||:.:.:.:.::.|.:
Mouse   910 FDGERYIFEGSCEYTLAQDYCRGNTSTNGTFRIVTENVPCGTTGTTCSKTIKIFVESYELILHEG 974

  Fly   452 RMRVKVNGTRVTLPYFVVAGGQNVTIERLANGGAVMLRSEMGLTLEWNGAGFLQVSVPAKFKKRL 516
            ..:|...|.....||.:...|..:.||         :||  |:.:.|:....:.|.:...:|.|:
Mouse   975 NFKVVEQGPSGDPPYKIRFMGIFLVIE---------IRS--GIVVSWDRKTSVFVRLQQHYKGRV 1028

  Fly   517 CGLCGNFNGSSRDDLTGKDGRSHGDDEVWHFANSWKVGGPKSCSRKREFLAATPTC-------DK 574
            |||||||:.::.:|.|.:.....||  |..|.||||.               :|:|       |.
Mouse  1029 CGLCGNFDDNAINDFTTRSQSVVGD--VLEFGNSWKF---------------SPSCPDAPVPKDP 1076

  Fly   575 RKSNFY--------CHPLSVPALFGECNERLNPENYKAACRMDVCECPSG---DCHCDSFAAYAH 628
            ..:|.|        |..:: .|.|..|:.:::...|..||..|||.|.||   :|.|.:.||||.
Mouse  1077 CIANPYRKSWAQKKCSIIN-SATFAACHSQVDSTKYYEACVHDVCACDSGGDCECFCTAVAAYAQ 1140

  Fly   629 ECRRLGVQLPDWRSATNCP 647
            .||.:||.| .||:...||
Mouse  1141 ACRDVGVCL-SWRTPDICP 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	16/67 (24%)
		VWC	256..310	CDD:278520	15/58 (26%)
		VWC	319..376	CDD:214564	18/74 (24%)
		VWD	371..536	CDD:214566	55/186 (30%)
		C8	580..646	CDD:285899	27/76 (36%)
Muc5b	NP_083077.2	VWD	80..227	CDD:214566
		C8	263..329	CDD:285899
		TIL	333..389	CDD:280072
		VWC_out	391..>436	CDD:214565
		VWD	418..582	CDD:214566	11/44 (25%)
		C8	619..700	CDD:214843	20/114 (18%)
		TIL	710..756	CDD:280072	13/53 (25%)
		TIL	798..859	CDD:280072	16/71 (23%)
		VWD	888..1047	CDD:214566	52/169 (31%)
		C8	1087..1157	CDD:285899	26/71 (37%)
		Mucin2_WxxW	1345..1432	CDD:290069
		Mucin2_WxxW	1574..1663	CDD:290069
		NUDE_C	<1676..1796	CDD:282704
		Mucin2_WxxW	1870..1959	CDD:290069
		Mucin2_WxxW	2184..2273	CDD:290069
		Mucin2_WxxW	2498..2587	CDD:290069
		Mucin2_WxxW	2687..2776	CDD:290069
		Herpes_BLLF1	<2920..3410	CDD:282904
		Mucin2_WxxW	3066..3155	CDD:290069
		Mucin2_WxxW	3380..3469	CDD:290069
		PHA03255	3475..>3621	CDD:165513
		Mucin2_WxxW	3625..3713	CDD:290069
		Mucin2_WxxW	3779..3867	CDD:290069
		VWD	4111..4283	CDD:214566
		C8	4336..4398	CDD:285899
		VWC	4570..4631	CDD:214564
		CT	4708..4790	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10953
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810