DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-2 and Bmper

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_082748.1	Gene:	Bmper / 73230	MGIID:	1920480	Length:	685	Species:	Mus musculus

Alignment Length:	678	Identity:	226/678 - (33%)
Similarity:	312/678 - (46%)	Gaps:	92/678 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WKFPAQQPRKSLASR--RRHTGFRPSTQLLILIAVLLALLQGRTVDAGAGDSLSGVRQSCSNEGE 71
            |.|..    ::||.|  ||..|        |...|||.|.......:.|...|:|....|.||||
Mouse     3 WFFSV----RALAERPCRRSPG--------ITCCVLLLLNCSGVPMSLASSFLTGSVAKCENEGE 55

  Fly    72 EVQ---LKNQPQIFTCFKCECQNGFVNC-RDTCPPVN-DCYILDKSNGTCCRRCKGCSFRGMSYE 131
            .:|   :.:.|    |..|.|.|..|.| |:.||.:: ||.:..|..|.||.|||||:..|.:|.
Mouse    56 VLQIPFITDNP----CIMCVCLNKEVTCKREKCPVLSRDCALAIKQRGACCERCKGCTHEGRTYN 116

  Fly   132 SGSEWNDPEDPCKTYKCVATVVTETIQKCYSQCDNNQLQPPRPGECCPTCQGCKINGQTVAEGHE 196
            |..:|..|.:||...:|...||||:..:|...|.|   .....|.|||||.||...|....||.|
Mouse   117 SSFKWQTPAEPCVLRQCQEGVVTESEVRCVVHCKN---PAEHQGACCPTCPGCVFEGVQYREGEE 178

  Fly   197 VDASIDDRCLVCQCRGTQLTCSKKTCPVLPCPMSKQIKRPDECCPRCPQNHSFLPVP-GKCLFNK 260
            .... .::|:.|.|.|.:..|.::.||:|.||.........:|||:|........:| |.|||..
Mouse   179 FQPE-GNKCITCSCVGGRTQCVREVCPILSCPQHLSHTPSGQCCPKCLGQRKVFDLPFGSCLFRS 242

  Fly   261 SVYPEKTQFMPDRCTNCTCLNGTSVCQRPTCPILECAPEFQEPDGCCPRCAV---AEVRSECSLD 322
            .||.....|:.|.||.|||.:.|.||::.......|.   .:.|.||..|.:   .|....|...
Mouse   243 DVYDNGASFVYDNCTVCTCKDSTMVCKKKCSHPGVCN---SDEDACCEDCLLRVPPEDIKVCKFG 304

  Fly   323 GIVYQNNETWDMGPCRSCRCNGGTIRCAQMRC-PAVKCRANEELKQPPGE------CCQRCVETA 380
            ..::::.|.|....|..|.|..|...|.:.:| |...|        |.|:      ||..|.|..
Mouse   305 SKIFRDGEMWSSVNCSICACVKGKTECRKKQCVPVSSC--------PQGKILNRKGCCPICTEKP 361

  Fly   381 GTCTVFGDPHFRTFDGKFFSFQGSCKYLLASDCM--GKTFHIRLTNEGRGTRRASWAKTVTLSLR 443
            |.||||||||:.||||:.|:|||:|:|:|..||.  ...|.:.:.|:.|.||..||.|:|.|.|.
Mouse   362 GVCTVFGDPHYNTFDGRTFNFQGTCQYVLTKDCSSPASPFQVLVKNDARRTRSFSWTKSVELMLG 426

  Fly   444 NLKVNLGQRMRVKVNGTRVTL----PYFVVAGGQNVTIERLANGGAVMLRSEMGLTLEWNGAGFL 504
            ...|:|.|.:.|:.||:|:.|    |:|.:.          .:|..:.:.:..||.:.|:|..|:
Mouse   427 ESTVSLQQHLTVRWNGSRIALPCHTPHFHID----------LDGYLLKVTTRAGLEISWDGDSFV 481

  Fly   505 QVSVPAKFKKRLCGLCGNFNGSSRDDLTGKDGRSHGDDEVWHFANSWKVGGPKSCSRKRE----- 564
            :|......|.:|||||||:||..||||.|.||....|  |..||.||:|...:.|:|.:.
Mouse   482 EVMAAPHLKGKLCGLCGNYNGHKRDDLIGGDGNFKFD--VDDFAESWRVESNEFCNRPQRKPVPE 544

  Fly   565 --------FLAATPTCDKRKSNFYCHPLSVPALFGECNERLNPENYKAACRMDVCECP-SGDCHC 620
                    .|.|...|.|.||          ..|..|:..::...:..:|..|:|||| ..:|:|
Mouse   545 LCQGTVKVKLRAHRECQKLKS----------WEFQTCHSTVDYTTFYRSCVTDMCECPVHKNCYC 599

  Fly   621 DSFAAYAHECRRLGVQLPDWRSATNCPA 648
            :||.||...|:|.|::: .|....:|.|
Mouse   600 ESFLAYTRACQREGIKV-HWEPQQSCAA 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	18/58 (31%)
		VWC	256..310	CDD:278520	19/53 (36%)
		VWC	319..376	CDD:214564	15/63 (24%)
		VWD	371..536	CDD:214566	69/176 (39%)
		C8	580..646	CDD:285899	18/66 (27%)
Bmper	NP_082748.1	VWC	166..224	CDD:278520	18/58 (31%)
		VWC	301..357	CDD:302663	15/63 (24%)
		VWD	364..508	CDD:278521	61/153 (40%)
		C8	556..624	CDD:285899	23/78 (29%)
		TIL	629..682	CDD:280072
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I7033
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12494
Inparanoid	1	1.050	375	1.000	Inparanoid score	I2071
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47479
OrthoDB	1	1.010	-	-		D1104860at2759
OrthoFinder	1	1.000	-	-		FOG0006882
OrthoInspector	1	1.000	-	-		oto94736
orthoMCL	1	0.900	-	-		OOG6_106931
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5817
SonicParanoid	1	1.000	-	-		X5778
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.810