Protein Alignment cv-2 and MUC5B

DIOPT Version :10

• Sequence 1: NP_524809.2
• Gene: cv-2 / 45280
• FlyBaseID: FBgn0000395
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_002449.2
• Gene: MUC5B / 727897
• HGNCID: 7516
• Length: 5762
• Species: Homo sapiens
• Alignment Length: 739
• Identity: 179/739 - (24%)
• Similarity: 261/739 - (35%)
• Gaps: 221/739 - (29%)

  Fly    27 TGFRPST-----------QLLILIAVLLALLQGRTVDAGAGDSLSGVRQSCSNEGEEVQL----- 75
            |.|.||:           |||:.:..|:.:.               ||...:::|:...|
Human   517 TLFTPSSFFIVVQTGLGLQLLVQLVPLMQVF---------------VRLDPAHQGQMCGLCGNFN 566

  Fly    76 KNQPQIFTCF-----------------KCECQNGFVNCRDTC--PPVNDCYILDKSNGTCCR--- 118
            :||...||..                 :..|.|...:..|.|  ...|:.|    :...|.|
Human   567 QNQADDFTALSGVVEATGAAFANTWKAQAACANARNSFEDPCSLSVENENY----ARHWCSRLTD 627

  Fly   119 ------RC----------KGCSFRGMSYESGSEWNDPEDPC---KTYKCVATVVTETIQKCYSQC 164
                  ||          ..|.|               |.|   ::..|:...::..:..|.::
Human   628 PNSAFSRCHSIINPKPFHSNCMF---------------DTCNCERSEDCLCAALSSYVHACAAK- 676

  Fly   165 DNNQLQPPRPGECCPTCQGCKINGQTVAEGHEVDASIDDRCLVCQ--CRG---TQLTCSKKTCPV 224
             ..||...|.|.|....|.|. ..|..|  :.|||        ||  |||   ..:|||....||
Human   677 -GVQLSDWRDGVCTKYMQNCP-KSQRYA--YVVDA--------CQPTCRGLSEADVTCSVSFVPV 729

  Fly   225 --LPCPMSKQIKRPDECCP--RCP-QNHSFLPVPGKCLFNKSVYPEKTQFMPDRCTNCTCLNGTS 284
              ..||....:.....|.|  .|| ..|..:..||:.:.::...             |:|..|..
Human   730 DGCTCPAGTFLNDAGACVPAQECPCYAHGTVLAPGEVVHDEGAV-------------CSCTGGKL 781

  Fly   285 VCQRPTCPILECAPEFQEPDGC--------CPRCAVAEVRSECSLDGIVYQNNETWDMGPCRSCR 341
            .|         .....|:..||        |...:.....:||      .::..|.|:| |.|..
Human   782 SC---------LGASLQKSTGCAAPMVYLDCSNSSAGTPGAEC------LRSCHTLDVG-CFSTH 830

  Fly   342 C--------------NGGTIRCAQMRCPAVKCRANEELKQPPGEC----CQRCV------ETA-- 380
            |              :||.|  |:..||.|    :.|....|||.    |..|.      |.:
Human   831 CVSGCVCPPGLVSDGSGGCI--AEEDCPCV----HNEATYKPGETIRVDCNTCTCRNRRWECSHR 889

  Fly   381 ---GTCTVFGDPHFRTFDGKFFSFQGSCKYLLASDCMGK-----TFHIRLTNEGRGTRRASWAKT 437
               |||..:||.||.||||..:||:|||:|:||.|..|.     ||.|...|...||...:.:|.
Human   890 LCLGTCVAYGDGHFITFDGDRYSFEGSCEYILAQDYCGDNTTHGTFRIVTENIPCGTTGTTCSKA 954

  Fly   438 VTLSLRNLKVNLGQ-RMRVKVNGTRVTLPYFVVAGGQNVTIERLANGGAVMLRSEMGLTLEWNGA 501
            :.|.:.:.::.|.: ..:....|.....||            ::...|..::....|:.:.|:..
Human   955 IKLFVESYELILQEGTFKAVARGPGGDPPY------------KIRYMGIFLVIETHGMAVSWDRK 1007

  Fly   502 GFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTGKDGRSHGDDEVWHFANSWKVGGPKSCSRKREFL 566
            ..:.:.:...:|.|:|||||||:.::.:|...:.....||  ...|.||||:.  .||.   :.|
Human  1008 TSVFIRLHQDYKGRVCGLCGNFDDNAINDFATRSRSVVGD--ALEFGNSWKLS--PSCP---DAL 1065

  Fly   567 AATPTCDK---RKS--NFYCHPLSVPALFGECNERLNPENYKAACRMDVCECPSG---DCHCDSF 623
            |....|..   |||  ...|..|..|. |..|..:::...|..||..|.|.|.||   :|.|.:.
Human  1066 APKDPCTANPFRKSWAQKQCSILHGPT-FAACRSQVDSTKYYEACVNDACACDSGGDCECFCTAV 1129

  Fly   624 AAYAHECRRLGVQLPDWRSATNCP 647
            ||||..|...|:.: .||:...||
Human  1130 AAYAQACHDAGLCV-SWRTPDTCP 1152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	20/67 (30%)
		VWC	256..310	CDD:278520	8/61 (13%)
		VWC	319..376	CDD:214564	19/74 (26%)
		VWD	371..536	CDD:214566	50/185 (27%)
		C8	580..646	CDD:462584	23/68 (34%)
MUC5B	NP_002449.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3481..3561
		Mucin2_WxxW	3577..3665	CDD:463846
		11 X approximate tandem repeats, Ser/Thr-rich	3676..4013
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3699..3779
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3813..3917
		Chi1	3878..>4080	CDD:442692
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3956..4118
		Mucin2_WxxW	4134..4222	CDD:463846
		23 X approximate tandem repeats, Ser/Thr-rich	4233..4879
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4259..4389
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4428..4447
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4458..4527
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4541..4750
		VWD	5064..5237	CDD:214566
		C8	5290..5351	CDD:462584
		TIL	5359..5414	CDD:410995
		VWC	5523..5586	CDD:214564
		CT	5660..5742	CDD:214482
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..50
		VWD	70..223	CDD:214566
		C8	261..325	CDD:462584
		TIL	329..385	CDD:460351
		VWC_out	387..>432	CDD:214565
		VWD	425..579	CDD:459671	16/76 (21%)
		C8	615..685	CDD:214843	13/90 (14%)
		TIL	695..752	CDD:410995	20/67 (30%)
		TIL	794..855	CDD:460351	14/69 (20%)
		VWD	884..1041	CDD:214566	47/168 (28%)
		C8	1078..1152	CDD:214843	25/75 (33%)
		7 X Cys-rich subdomain repeats	1333..4228
		Mucin2_WxxW	1340..1426	CDD:463846
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1437..1462
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1480..1502
		Mucin2_WxxW	1509..1597	CDD:463846
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1607..1783
		DUF5585	1630..>1767	CDD:465521
		Mucin2_WxxW	1790..1878	CDD:463846
		11 X approximate tandem repeats, Ser/Thr-rich	1890..2199
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1890..2019
		Herpes_BLLF1	<1928..2313	CDD:282904
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2031..2100
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2114..2211
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2242..2302
		Mucin2_WxxW	2320..2408	CDD:463846
		11 X approximate tandem repeats, Ser/Thr-rich	2419..2756
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2443..2462
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2473..2522
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2556..2861
		Chi1	2644..>2868	CDD:442692
		Mucin2_WxxW	2877..2965	CDD:463846
		17 X approximate tandem repeats, Ser/Thr-rich	2976..3456
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3001..3049
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3256..3357
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3371..3469
		Chi1	3375..>3573	CDD:442692