DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cv-2 and vwf

DIOPT Version :9

Sequence 1:NP_524809.2 Gene:cv-2 / 45280 FlyBaseID:FBgn0000395 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_001268918.1 Gene:vwf / 570643 ZFINID:ZDB-GENE-070103-1 Length:2812 Species:Danio rerio


Alignment Length:959 Identity:208/959 - (21%)
Similarity:314/959 - (32%) Gaps:358/959 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 GRTVDAGAGDSLSGVRQ-SCSNEGEEVQLKNQPQIF---TCFKCECQNGFVNC-RDTCPPVNDCY 107
            |:.:|   ||....|.| ||::.|.    :..|..:   .|..|.|::|...| .:.||  .:|.
Zfish   327 GKVLD---GDRCVDVSQCSCTHAGR----RYPPASYISQDCNTCVCRHGSWECTNEGCP--GECL 382

  Fly   108 ILDKS------------NGTC-----------------------------CRRCKGCSFRGMSYE 131
            :..:|            :|.|                             |.|.....|:.::.:
Zfish   383 VTGQSHYKTFDNKFFTFSGICHYLLAKDCQSNSFSAVIETAQCADDQDAICTRSITLRFKDLANQ 447

  Fly   132 S---------GSEWNDPEDP--------------------------------------------- 142
            :         ..:..|.:.|                                             
Zfish   448 TVHLKHGGVVSVDGMDVQTPLINGPLRIQNTVLSSVRLRYGHDLHLDWDGRGRVLLRLKPAYAGQ 512

  Fly   143 ----CKTYK--------CVATVVTETIQ------KCYSQCDNNQLQPPRP-----------GECC 178
                |..|.        .|..:|...::      |..:.||:.|:|...|           .|.|
Zfish   513 MCGLCGNYNGNQGDDFLTVGGLVETRVEAFGNSWKMNADCDDVQMQNSDPCSLNPKRVRFAEEAC 577

  Fly   179 ------------------PTCQGCKINGQTVAEGHE--VDASIDDRCLVCQCRGT---------- 213
                              |..:.|:.:....|:|.|  .|| :....:.|..||.          
Zfish   578 AVLLSMKFEPCHYMVNPEPYVKNCRYDVCACADGQECLCDA-VSSYAVACAARGVLVNWRSHGYC 641

  Fly   214 QLTC------------SKKTCPVLP---------------CPMSKQIKRPDECCPRCPQNHSFLP 251
            :|||            ..:||..|.               ||....:....||.|  ||:.|   
Zfish   642 ELTCPDAQVYEMCGSVCNQTCRSLSLPDTGCDGVCEEGCFCPRGLFLSDAGECVP--PQHCS--- 701

  Fly   252 VPGKCLFNKSVYPEKTQFMPDRCTNCTCLNGTSVC-----------------QRPT--CPILECA 297
                |..|..:: |....:.|..:.|.|.:|:..|                 |.|:  ...|.|.
Zfish   702 ----CHHNGEIF-EPNDMIGDHHSICVCESGSMHCTSNEATGSTLSDLFFDEQSPSRGRRSLSCP 761

  Fly   298 PEFQEPDGCCPRCAVAEVRSECSLDGIVYQNNE--TWDMGPCRSCRCNGGTIR----C-AQMRCP 355
            |..|..:....|.|..|....|       ||.|  ...:|....|.|..||:|    | .|.:||
Zfish   762 PPLQRFECESARDAGIECAKTC-------QNLELDCVSLGCVSGCMCPPGTVRYRKDCIPQEQCP 819

  Fly   356 AVKCRANEE----------------LKQPPGECCQRCVETAGTCTVFGDPHFRTFDGKFFSFQGS 404
               |..|..                .:|...:|.:|..:  |.|...||.|:.:|||..|||.|.
Zfish   820 ---CYHNSRPYESGQSITVDCNTCVCEQRQWKCSERVCD--GVCRAIGDTHYISFDGLKFSFPGP 879

  Fly   405 CKYLLASD-CMG--KTFHIRLTNEGRGTRRASWAKTVT-LSLRNLKVNLGQRMRVK---VNGTRV 462
            |:|:||.| |.|  .||.:.:.|...|......:|::| |.:..|.|.....:|:|   :..|.|
Zfish   880 CQYVLAQDYCNGLDGTFRVLVENSACGIAGYRCSKSITVLYMGGLIVMEHGEVRMKRPVLKETEV 944

  Fly   463 TLP----YFVVAGGQNVTIERLANGGAVMLRSEMGLTLEWNGAGFLQVSVPAKFKKRLCGLCGNF 523
            .:.    |::|..|::::|                   .|:....:.:.:..:::.::|||||||
Zfish   945 EIVRSGLYYIVLLGKHISI-------------------TWDTGTRISLQISGQYRGKVCGLCGNF 990

  Fly   524 NGSSRDDLTGKDGRSHGDDEVWHFANSWKVGGPKSCSRKREFLAATPTCDKRKSNFY-----CHP 583
            :||..:||.....:...|  ...|.|||||  ..||:   :.::....|........     |..
Zfish   991 DGSQNNDLLSSSNQMEVD--AADFGNSWKV--RPSCA---DAVSVVSQCSTDLVKLVTVEQSCRV 1048

  Fly   584 LSVPALFGECNERLNPENYKAACRMDVCECPS-GD--CHCDSFAAYAHECRRLGVQLPDWRSATN 645
            |: .|:|.:||..::||.|...|..|.|.||| ||  |.|::.|||||||.:.|:.: :|||...
Zfish  1049 LT-SAIFRDCNSVVDPEPYWDICTQDTCSCPSVGDCACFCNTIAAYAHECAQKGLPV-NWRSNDL 1111

  Fly   646 CPAG-------------WRRNATLSSFKGNQFYGDPSFSRMKGRRQKNHQLRLQLQQEQQQRSKQ 697
            ||..             ||.|...|:......:.:|              |...:...:      
Zfish  1112 CPLSCEDLNKESGVQCEWRYNTCASACPSTCQHPEP--------------LSCPISCVE------ 1156

  Fly   698 GQKGRHK--PGGHNQLDRQGHNGLDKDQLQ------------KEFILKH 732
               |.|.  |.|| .||......::..|.|            |:|||.|
Zfish  1157 ---GCHAVCPPGH-LLDEVLRKCVEPSQCQVCVHDGQRVSHGKQFILNH 1201

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cv-2NP_524809.2 VWC 184..243 CDD:214564 20/97 (21%)
VWC 256..310 CDD:278520 14/72 (19%)
VWC 319..376 CDD:214564 18/79 (23%)
VWD 371..536 CDD:214566 50/175 (29%)
C8 580..646 CDD:285899 30/73 (41%)
vwfNP_001268918.1 VWD 29..167 CDD:278521
C8 <227..284 CDD:214843
TIL 288..341 CDD:280072 5/16 (31%)
VWC 343..>387 CDD:302663 11/49 (22%)
VWD 381..534 CDD:278521 12/152 (8%)
C8 573..641 CDD:285899 12/68 (18%)
TIL 645..700 CDD:280072 11/56 (20%)
TIL 760..818 CDD:280072 18/64 (28%)
VWD 847..1003 CDD:214566 50/176 (28%)
C8 1043..1112 CDD:285899 30/70 (43%)
TIL 1131..1181 CDD:280072 11/73 (15%)
VWA_N2 1183..>1222 CDD:292782 5/19 (26%)
VWA 1257..1421 CDD:278519
vWFA_subfamily_ECM 1493..1628 CDD:238727
VWA 1693..1848 CDD:278519
VWD 1939..2091 CDD:214566
C8 2131..2194 CDD:285899
CT 2731..2808 CDD:214482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.900

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