DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-2 and fras1

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_005165392.1	Gene:	fras1 / 563428	ZFINID:	ZDB-GENE-060526-68	Length:	4003	Species:	Danio rerio

Alignment Length:	739	Identity:	171/739 - (23%)
Similarity:	238/739 - (32%)	Gaps:	199/739 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 ILIAVLLALLQGRTVDAGAGDSLSGVRQSCSNEGEEVQLKNQPQIFTCFKCECQNGFVNCRDT-- 99
            |.|.:|..|:...|:..||       ..:|.::|.........:..||..|.|.|..|.|:.|
Zfish     4 IRILLLTILIGYSTISPGA-------EGACVHQGSLFANNTSWKPDTCQDCICYNDIVICKPTRC 61

  Fly   100 ----C----------PPVNDCYILDKSNGTCCRRCKG-----CSFRGMSYESGSEWNDPEDPCKT 145
                |          ||           ..||..|..     |...|:.|...|:|::.:  |..
Zfish    62 RNPQCDFPRGERLRIPP-----------NKCCPECFAPSPGICHHEGLVYGHDSQWSNSK--CSV 113

  Fly   146 YKCVATVVTETIQKCYS-QCDNNQLQPPRPGECCPTCQ----GCKINGQTVAEGHEVDASIDDRC 205
            ..|....||...:.|.. .|..:|......|.|||.|.    .|...|:...:|.|..:|   .|
Zfish   114 CTCAHGKVTCGPRACPPLSCGKDQSPFIPDGNCCPVCAHNGVSCSWEGREYRDGLEWTSS---PC 175

  Fly   206 LVCQCRGTQLTCSKKTCPVLPCPMSKQ-IKRPDECCPRCPQNHSFLPVPGKCLFNKSVYPEKTQF 269
            ..|:||.....|....|..:.|.:::. :..|.:|||:|.        |..|:...:.|....|:
Zfish   176 TKCRCRNGHTECLVAECQPVTCKVNENLVVHPGQCCPQCE--------PNPCMEAGNEYKHGEQW 232

  Fly   270 MPDRCTNCTCLNGTSVCQRPTCPILEC---APEFQEPDGCCPRCAVAEVRSECSLDGIVYQNNET 331
            ....||.|.|..|.|.||...||.|.|   ..:.:..|.||..||.:  :..|..:|||..:.:.
Zfish   233 QRSSCTTCVCDRGHSRCQTEKCPPLHCDKGQTKVKRADQCCEDCATS--KGSCLYEGIVRYHGDM 295

  Fly   332 WDMGPCRSCRCNGGTIRCAQMRCPAVKCRANEELKQPPGECCQRCVETAGTCTVF-----GDPHF 391
            |:...|..|.|..|.:.|.::.|...:|...|:|...||:||..|..|..:||..     |....
Zfish   296 WNGTGCEFCMCERGQVLCQRVECSRSECPRGEKLVHLPGKCCPECKTTTSSCTYSQPDQKGQKAI 360

  Fly   392 RTF--------------------DGKFFSFQGSC------------KYLLASDCMG--KTFHIRL 422
            ::|                    :|....:|.||            :.....||..  |.....|
Zfish   361 KSFRRLSNLEIVREGLCRECQCQEGHVTCYQHSCPTCPLGTLTIPHREQCCPDCNPEVKCHEDCL 425

  Fly   423 TNEGRGTRRASWAKTVTLSLRNLKVNLGQRMRVKVNGTRVTLPYF----VVAGGQ------NVTI 477
            |..|.....||......|.:.      |:.::....|      :|    |.|..|      ....
Zfish   426 TCSGTPDHCASCRDPSALLMN------GRCLQACPQG------FFAQGKVCAACQPSCATCENDF 478

  Fly   478 ERLANGGAVMLRSEMGL-TLEWNGAGFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTG-------K 534
            |..|.||:.:|.....: |.|   .|..|..........||..|.  ....:|.||.       |
Zfish   479 ECTACGGSFLLSGRQCVATCE---RGLFQAHTHCLSCHDLCSSCQ--GAGPQDCLTCSDSSHLLK 538

  Fly   535 DGRSHGDDEVWHFANSWKVGGPKSCSRKREFLAATPTCDKRKSNFYCHP-----LSVPALF---- 590
            ||....|            .||...:.:....|..|:|..      |.|     :|.||..
Zfish   539 DGYCVSD------------CGPGFYTSQGNCYACDPSCAT------CQPDSPSCMSCPAEHALHQ 585

  Fly   591 GECNERLNPENYK------AACRMDVCECPSGDC--HCDSF----------------------AA 625
            |:|..:...:.||      .||......| ||..  ||.|.                      |.
Zfish   586 GKCAPQCPAQYYKDDHGRCQACHSSCASC-SGPAVSHCTSCSKALILNQGQCVESCGEGLFSRAG 649

  Fly   626 YAHECR---RLGVQLPDWRSATNC 646
            :.|.|.   |:.|. ||....|.|
Zfish   650 HCHSCHSSCRVCVG-PDSSDCTQC 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	16/59 (27%)
		VWC	256..310	CDD:278520	18/56 (32%)
		VWC	319..376	CDD:214564	18/56 (32%)
		VWD	371..536	CDD:214566	43/221 (19%)
		C8	580..646	CDD:285899	25/107 (23%)
fras1	XP_005165392.1	VWC	26..85	CDD:278520	15/69 (22%)
		VWC	93..150	CDD:278520	16/58 (28%)
		VWC	157..214	CDD:278520	16/59 (27%)
		VWC	219..276	CDD:278520	18/56 (32%)
		VWC	283..340	CDD:278520	18/56 (32%)
		VWC	364..414	CDD:302663	4/49 (8%)
		FU	419..465	CDD:238021	11/57 (19%)
		Furin-like_2	424..512	CDD:292535	21/102 (21%)
		FU	461..503	CDD:214589	11/44 (25%)
		FU	507..551	CDD:214589	12/57 (21%)
		GF_recep_IV	512..669	CDD:291509	39/178 (22%)
		FU	555..597	CDD:214589	10/47 (21%)
		Furin-like	588..762	CDD:279142	20/87 (23%)
		FU	602..645	CDD:214589	8/43 (19%)
		FU	648..700	CDD:214589	9/26 (35%)
		FU	704..748	CDD:214589
		Furin-like	737..911	CDD:279142
		FU	754..796	CDD:214589
		FU	855..897	CDD:214589
		Furin-like	888..1054	CDD:279142
		FU	950..994	CDD:214589
		FU	1044..1086	CDD:214589
		Cadherin_3	<1097..1196	CDD:292802
		Cadherin_3	1166..1306	CDD:292802
		Cadherin_3	1406..1538	CDD:292802
		Cadherin_3	1526..1689	CDD:292802
		Cadherin_3	1658..1811	CDD:292802
		Cadherin_3	1777..1934	CDD:292802
		Cadherin_3	1901..2056	CDD:292802
		Cadherin_3	2025..2175	CDD:292802
		Cadherin_3	2144..2290	CDD:292802
		Cadherin_3	2258..2403	CDD:292802
		Cadherin_3	2372..2534	CDD:292802
		Calx-beta	2550..2647	CDD:295344
		Calx-beta	2672..2771	CDD:295344
		Calx-beta	2795..2891	CDD:295344
		Calx-beta	2917..3008	CDD:295344
		Calx-beta	3036..3130	CDD:295344
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10530
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810