DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-2 and CRIM1

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_011531200.1	Gene:	CRIM1 / 51232	HGNCID:	2359	Length:	1077	Species:	Homo sapiens

Alignment Length:	703	Identity:	149/703 - (21%)
Similarity:	213/703 - (30%)	Gaps:	275/703 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 RTVDAGAG---------DSLSGVRQSC--SN----EGEEVQLKNQPQIFTCFKCECQNGFVNC-R 97
            |.|..|.|         :.::..:.:|  :|    :|:..::.|      |..|.||.|...| .
Human   351 RIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDN------CRFCRCQGGVAICFT 409

  Fly    98 DTCPPVNDCYILDKSNGTCCRRCK----------GCSFRGMSYESGSEWNDPEDPCKTY------ 146
            ..|..:| |.......|.||..|:          ||...|:....|..|.  ||.| |:
Human   410 AQCGEIN-CERYYVPEGECCPVCEDPVYPFNNPAGCYANGLILAHGDRWR--EDDC-TFCQCVNG 470

  Fly   147 --KCVATVVTETIQKCYSQCDNNQLQPPR-PGECCPTCQ----------------GCKINGQTVA 192
              .|||||       |...|.|    |.: ||||||.|:                .|.:.|:...
Human   471 ERHCVATV-------CGQTCTN----PVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCI 524

  Fly   193 EGHEVDASIDDRCLVCQCRGTQLTCSKK------TCP------VLPCPMSKQIKRPDEC------ 239
            .|.:.|   .:.|..|||..|:..||::      .||      ...|.:.:...||.:|
Human   525 NGFKRD---HNGCRTCQCINTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICD 586

  Fly   240 ------------------CPRCPQ--------------NHSFL-------------PV-PGKCLF 258
                              |.:||:              :|..|             |: .|.||.
Human   587 KYCPLGLLKNKHGCDICRCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLT 651

  Fly   259 NKSVYPEKTQFMPDRCTNCTCLNGTSVCQRPTCPILECAPEFQEPDGCCPRCAVAEVRSECSLD- 322
            ....:.:..:...|.|..|.||||..:|...|||:..|......|..|||.||...|..:..|.
Human   652 VDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELST 716

  Fly   323 --------GIVYQNNETWDMGPCRSCRCNGGTIRCAQMRCPAVKCRANEELKQPPGECCQRCVET 379
                    |..:...|||::..|..|.|:.|.:.|....||.:.|: |....|  ..||.:|.
Human   717 PSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQ-NPSRTQ--DSCCPQCT-- 776

  Fly   380 AGTCTVFGDPHFRTFDGKFFSFQGSCK-----YLLASDCMGKTFHIRLTNEGRGTRRASWAKTVT 439
                    |..||....:..|....||     ..||::                    ||...|.
Human   777 --------DQPFRPSLSRNNSVPNYCKNDEGDIFLAAE--------------------SWKPDVC 813

  Fly   440 LSLRNLKVNLGQRMRVKVNGTRVTLPYFVVAGGQ---NVTIERLANGGAVMLRSEMGLTLEWNGA 501
            .|.                   :.:...:....:   :|:.||
Human   814 TSC-------------------ICIDSVISCFSESCPSVSCER---------------------- 837

  Fly   502 GFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTGK-----DGRSHGDDEVWHFANSWKVGGPKSCSR 561
                   |...|.:.|..|      ..|.:..|     .|:::.|:|.|..         .||:.
Human   838 -------PVLRKGQCCPYC------IEDTIPKKVVCHFSGKAYADEERWDL---------DSCTH 880

  Fly   562 KREFLAATPTCDKRKSNFYCHPLSVPALFGECNERLNPENYKAACRMDVCECP 614
                      |...:....|..:|.|.|  .|.|.:|.|.  :.|.|    ||
Human   881 ----------CYCLQGQTLCSTVSCPPL--PCVEPINVEG--SCCPM----CP 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	18/94 (19%)
		VWC	256..310	CDD:278520	18/53 (34%)
		VWC	319..376	CDD:214564	17/65 (26%)
		VWD	371..536	CDD:214566	24/177 (14%)
		C8	580..646	CDD:285899	12/35 (34%)
CRIM1	XP_011531200.1	IGFBP	39..90	CDD:278641
		VWC	377..431	CDD:214564	16/60 (27%)
		VWC	444..497	CDD:214564	23/66 (35%)
		Antistasin	608..633	CDD:280912	4/24 (17%)
		VWC	653..703	CDD:302663	16/49 (33%)
		VWC	724..775	CDD:302663	16/53 (30%)
		VWC	799..849	CDD:214564	12/117 (10%)
		VWC	860..914	CDD:302663	17/80 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810