DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cv-2 and Crim1

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_056615.1	Gene:	Crim1 / 50766	MGIID:	1354756	Length:	1037	Species:	Mus musculus

Alignment Length:	353	Identity:	96/353 - (27%)
Similarity:	135/353 - (38%)	Gaps:	79/353 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 LKNQP--QIFTCFKCE-------CQNGF---------VNCRDTCPPVNDCYILDKSNGTCCRRCK 121
            |||:.  .|..|.||.       |..||         ..||:. ||.....:|   :|||
Mouse   553 LKNKHGCDICRCKKCPELPCSKICPLGFQQDSHGCLICKCREV-PPSAGPPVL---SGTC----- 608

  Fly   122 GCSFRGMSYESGSEWND--PEDPCKTYKCVATVVTETIQKCYSQCDNNQLQPPRPGECCPTCQG- 183
             .|..|..:::...|:|  .|..|...|.:..::|..:    ..|.|..:   |.|:|||:|..
Mouse   609 -LSMDGHHHKNEESWHDGCRECYCHNGKEMCALITCPV----PACGNPTI---RSGQCCPSCTDD 665

  Fly   184 -------------CKI-NGQTVAEGHEVDASIDDRCLVCQCRGTQLTCSKKTCPVLPC--PMSKQ 232
                         |.. .|:...||...:.   |.|..|.|...::.|..:.||.|.|  |...|
Mouse   666 FVVQKPELSTPSICHAPGGEYFVEGETWNI---DSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQ 727

  Fly   233 IKRPDECCPRC----PQ-----NHSFLPVPGKCLFNK-SVYPEKTQFMPDRCTNCTCLNGTSVCQ 287
                |.|||:|    ||     |.|   ||..|..:: .::.....:.||.||:|.|::....|.
Mouse   728 ----DSCCPQCTDDPPQPSTSHNES---VPSYCRNDEGDIFLAAESWKPDACTSCVCVDSAISCY 785

  Fly   288 RPTCPILECAPEFQEPDGCCPRCAVAEVRSE--CSLDGIVYQNNETWDMGPCRSCRCNGGTIRCA 350
            ..:||.:.|.........|||.|....:..:  |...|..|.:.|.||:..|..|.|..|...|:
Mouse   786 SESCPSVACERPVLRKGQCCPYCLEDTIPKKVVCHFSGKTYADEERWDIDSCTHCYCLQGQTLCS 850

  Fly   351 QMRCPAVKCRANEELKQPPGECCQRCVE 378
            .:.||.:.|.  |.:| ..|.||..|.|
Mouse   851 TVSCPPLPCA--EPIK-VEGSCCPMCPE 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	19/61 (31%)
		VWC	256..310	CDD:278520	14/54 (26%)
		VWC	319..376	CDD:214564	19/56 (34%)
		VWD	371..536	CDD:214566	4/8 (50%)
		C8	580..646	CDD:285899
Crim1	NP_056615.1	IB	37..>95	CDD:197525
		Cell attachment site. /evidence=ECO:0000255	314..316
		VWC	336..390	CDD:214564
		VWC	403..456	CDD:214564
		Antistasin	539..564	CDD:280912	4/10 (40%)
		Antistasin	567..592	CDD:280912	4/24 (17%)
		VWC	683..734	CDD:302663	18/57 (32%)
		VWC	758..808	CDD:302663	13/49 (27%)
		VWC	819..873	CDD:302663	19/56 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810