DRSC/TRiP Functional Genomics Resources

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Protein Alignment cv-2 and MUC5AC

DIOPT Version :10

Sequence 1:NP_524809.2 Gene:cv-2 / 45280 FlyBaseID:FBgn0000395 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_001291288.1 Gene:MUC5AC / 4586 HGNCID:7515 Length:5654 Species:Homo sapiens


Alignment Length:746 Identity:182/746 - (24%)
Similarity:271/746 - (36%) Gaps:234/746 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 TGFRPSTQLLI------------------LIAVLLALLQGRT---------VDAGAGDSLSGVRQ 64
            |.|||||..:|                  |...|...|:|:|         :.|....:||||.:
Human   526 TIFRPSTFFIIAQTSLGLQLNLQLVPTMQLFMQLAPKLRGQTCGLCGNFNSIQADDFRTLSGVVE 590

  Fly    65 SCSNEGEEVQLKNQPQIFTCFKCECQNGFVNCRDTCPPVNDCYILDKSNGTCCRRCKGCSFRGMS 129
            :.:           ...|..||.:.         .||.:.:.:.            ..||....:
Human   591 ATA-----------AAFFNTFKTQA---------ACPNIRNSFE------------DPCSLSVEN 623

  Fly   130 YESGSEW----NDPEDPCKTYKCVATVVTETIQKCYSQCDNNQLQPPRPGECCPTCQGCKINGQT 190
            .:....|    .|.:.|..  :|.|.|...|.   ||.|..:.....|..:|.     |      
Human   624 EKYAQHWCSQLTDADGPFG--RCHAAVKPGTY---YSNCMFDTCNCERSEDCL-----C------ 672

  Fly   191 VAEGHEVDASIDDRCLVCQCRGTQL------TCSK--KTCP--------VLPC-PMSKQIKRPDE 238
                    |::......|..:|.||      .|:|  .|||        |..| |..:.:...|.
Human   673 --------AALSSYVHACAAKGVQLGGWRDGVCTKPMTTCPKSMTYHYHVSTCQPTCRSLSEGDI 729

  Fly   239 CCP---------RCPQNHSFLPVPGKCL-------FNKSVYPEKTQFMPDRCTNCTCLNG----- 282
            .|.         .||:. :||...|||:       :::.......:.:.|....|||.:|     
Human   730 TCSVGFIPVDGCICPKG-TFLDDTGKCVQASNCPCYHRGSMIPNGESVHDSGAICTCTHGKLSCI 793

  Fly   283 -----TSVCQRP---------------------------TCPILECAPEFQEPDGCCP----RCA 311
                 ..||..|                           ||...:|.|....|||...    .|.
Human   794 GGQAPAPVCAAPMVFFDCRNATPGDTGAGCQKSCHTLDMTCYSPQCVPGCVCPDGLVADGEGGCI 858

  Fly   312 VAE----VRSECSLDGIVYQNNETWDMGPCRSCRCNGGTIRCAQMRCPAVKCRANEELKQPPGEC 372
            .||    |.:|.|     |:..:|..:| |.:|.|:....||....|.|                
Human   859 TAEDCPCVHNEAS-----YRAGQTIRVG-CNTCTCDSRMWRCTDDPCLA---------------- 901

  Fly   373 CQRCVETAGTCTVFGDPHFRTFDGKFFSFQGSCKY-LLASDCMGK-----TFHIRLTNEGRGTRR 431
                     ||.|:||.|:.||||:.:||.|.|:| |:.:.|.||     :|.:...|...||..
Human   902 ---------TCAVYGDGHYLTFDGQSYSFNGDCEYTLVQNHCGGKDSTQDSFRVVTENVPCGTTG 957

  Fly   432 ASWAKTVTLSLRNLKVNLGQRMRVKVNGTRVT--LPYFVVAGGQNVTIERLANGGAVMLRSEMGL 494
            .:.:|.:.:.|...::.|... :|:|.||..:  :||         ||.::  |..:::.:::||
Human   958 TTCSKAIKIFLGGFELKLSHG-KVEVIGTDESQEVPY---------TIRQM--GIYLVVDTDIGL 1010

  Fly   495 TLEWNGAGFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTGKDGRSHGDDEVWHFANSWKVGGPKSC 559
            .|.|:....:.:::..:||.|:|||||||:..:.:|...:.....||  |..|.||||:.  .||
Human  1011 VLLWDKKTSIFINLSPEFKGRVCGLCGNFDDIAVNDFATRSRSVVGD--VLEFGNSWKLS--PSC 1071

  Fly   560 SRKREFLAATPTCDK---RKS--NFYCHPLSVPALFGECNERLNPENYKAACRMDVCECPSG--- 616
            .   :.||....|..   |||  ...|..|..|. |..|:..:.|..|..||..|.|.|.||   
Human  1072 P---DALAPKDPCTANPFRKSWAQKQCSILHGPT-FAACHAHVEPARYYEACVNDACACDSGGDC 1132

  Fly   617 DCHCDSFAAYAHECRRLGVQLPDWRSATNCP 647
            :|.|.:.||||..|..:|:.: .||:.:.||
Human  1133 ECFCTAVAAYAQACHEVGLCV-SWRTPSICP 1162

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cv-2NP_524809.2 VWC 184..243 CDD:214564 16/84 (19%)
VWC 256..310 CDD:278520 16/101 (16%)
VWC 319..376 CDD:214564 11/56 (20%)
VWD 371..536 CDD:214566 50/172 (29%)
C8 580..646 CDD:462584 24/68 (35%)
MUC5ACNP_001291288.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 27..49
VWD 74..216 CDD:214566
C8 265..334 CDD:462584
TIL 338..394 CDD:410995
VWD 423..587 CDD:214566 14/60 (23%)
C8 624..694 CDD:214843 18/93 (19%)
TIL 704..761 CDD:410995 14/57 (25%)
TIL 802..863 CDD:410995 12/60 (20%)
VWD 892..1051 CDD:214566 54/195 (28%)
C8 1088..1162 CDD:214843 26/75 (35%)
PHA03247 <1335..1576 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1336..1377
9 X Cys-rich subdomain repeats 1383..4731
Mucin2_WxxW 1389..1475 CDD:463846
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1483..1575
Mucin2_WxxW 1584..1670 CDD:463846
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1688..1733
Mucin2_WxxW 1749..1840 CDD:463846
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1849..1948
Mucin2_WxxW 1957..2043 CDD:463846
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2059..2110
Mucin2_WxxW 2122..2213 CDD:463846
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2224..3214
107 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P 2257..3200
Mucin2_WxxW 3228..3319 CDD:463846
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3329..3515
17 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P 3363..3498
Mucin2_WxxW 3526..3617 CDD:463846
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3628..3951
34 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P 3661..3931
Mucin2_WxxW 3959..4050 CDD:463846
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4060..4625
58 X 8 AA approximate tandem repeats of T-T-S-T-T-S-A-P 4093..4595
Mucin2_WxxW 4633..4724 CDD:463846
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4830..4849
VWD 4911..5079 CDD:214566
C8 5146..5205 CDD:462584
CT 5534..5616 CDD:214482
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 5622..5654
Blue background indicates that the domain is not in the aligned region.

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