Protein Alignment cv-2 and MUC2

DIOPT Version :9

• Sequence 1: NP_524809.2
• Gene: cv-2 / 45280
• FlyBaseID: FBgn0000395
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_002448.4
• Gene: MUC2 / 4583
• HGNCID: 7512
• Length: 5289
• Species: Homo sapiens
• Alignment Length: 751
• Identity: 163/751 - (21%)
• Similarity: 266/751 - (35%)
• Gaps: 249/751 - (33%)

  Fly    29 FRPST-----------QLLILIAVLLALLQGRTVDAGAGDSLSGVRQSCSN----EGEEVQLKNQ 78
            ||||:           :|.:.:|.::.|..  |:|..:...:.|:   |.|    ||::
Human   485 FRPSSYHIMVSMAIGVRLQVQLAPVMQLFV--TLDQASQGQVQGL---CGNFNGLEGDD------ 538

  Fly    79 PQIFTCFK-----CECQN-GFVNCRDTCPPVNDCYILDKSNGTCCRRCKGCSFRGMSYESGSEWN 137
                  ||     .|... ||.|   |....:.|:  ||                      .:|.
Human   539 ------FKTASGLVEATGAGFAN---TWKAQSSCH--DK----------------------LDWL 570

  Fly   138 DPEDPCK---------TYKCVATVVTET-IQKCYSQCDNNQLQPPRPGECCPTCQ----GCKING 188
            |  |||.         .:.|.....||| ..:|:|..|        |.|....|:    .|:.|.
Human   571 D--DPCSLNIESANYAEHWCSLLKKTETPFGRCHSAVD--------PAEYYKRCKYDTCNCQNNE 625

  Fly   189 QTVAEGHEVDASIDDRCLVCQCRGTQL------TCSKK--TCP--------VLPCPMS-KQIKRP 236
            ..:.      |::......|..:|..|      .|:|.  :||        :..|..: :.:...
Human   626 DCLC------AALSSYARACTAKGVMLWGWREHVCNKDVGSCPNSQVFLYNLTTCQQTCRSLSEA 684

  Fly   237 DECCPR---------CPQNHSFLPVPGKCL-------FNKSVYPEKTQFMPDRCTNCTCLNGTSV 285
            |..|..         || :|:||...|:|:       :::.:|.|....:..:...|.|.:|...
Human   685 DSHCLEGFAPVDGCGCP-DHTFLDEKGRCVPLAKCSCYHRGLYLEAGDVVVRQEERCVCRDGRLH 748

  Fly   286 CQ---------------------------RP---TCPIL-------ECAPEFQEPDGC-CPRCAV 312
            |:                           :|   :|..|       ||.      .|| ||...:
Human   749 CRQIRLIGQSCTAPKIHMDCSNLTALATSKPRALSCQTLAAGYYHTECV------SGCVCPDGLM 807

  Fly   313 AEVRSECSLDG--IVYQNNETWDMG-----PCRSCRCNGGTIRCAQMRCPAVKCRANEELKQPPG 370
            .:.|..|.::.  ....||:.:..|     .|.:|.|..|...|.|..|
Human   808 DDGRGGCVVEKECPCVHNNDLYSSGAKIKVDCNTCTCKRGRWVCTQAVC---------------- 856

  Fly   371 ECCQRCVETAGTCTVFGDPHFRTFDGKFFSFQGSCKYLLASDCMGK-----TFHIRLTNEGRGTR 430
                     .|||:::|..|:.|||||::.|.|.|.|:...|..|:     :|.|...|...||.
Human   857 ---------HGTCSIYGSGHYITFDGKYYDFDGHCSYVAVQDYCGQNSSLGSFSIITENVPCGTT 912

  Fly   431 RASWAKTVTLSLRNLKVNLGQRMRVKVNGTRVTLPYFVVAGGQNVTIERLANGGAVMLRSEMGLT 495
            ..:.:|.:.:.:...::.|..:.||.:....          |.:|.......|..:::.|..|:.
Human   913 GVTCSKAIKIFMGRTELKLEDKHRVVIQRDE----------GHHVAYTTREVGQYLVVESSTGII 967

  Fly   496 LEWNGAGFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTGKDGRSHGDDEVWHFANSWKVG------ 554
            :.|:....:.:.:...:|..:|||||||:..|.:|.|.:|......:  ..|.||||..
Human   968 VIWDKRTTVFIKLAPSYKGTVCGLCGNFDHRSNNDFTTRDHMVVSSE--LDFGNSWKEAPTCPDV 1030

  Fly   555 --GPKSCS---RKREFLAATPTCDKRKSNFYCHPLSVPALFGECNERLNPENYKAACRMDVCECP 614
              .|:.||   .:|.:  |...|...||          ::|..|:.:::|:.:..||..|.|.|.
Human  1031 STNPEPCSLNPHRRSW--AEKQCSILKS----------SVFSICHSKVDPKPFYEACVHDSCSCD 1083

  Fly   615 SG---DCHCDSFAAYAHECRRLGVQLPDWRSATNCP 647
            :|   :|.|.:.|:||.||.:.|..: .||:...||
Human  1084 TGGDCECFCSAVASYAQECTKEGACV-FWRTPDLCP 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	13/84 (15%)
		VWC	256..310	CDD:278520	16/98 (16%)
		VWC	319..376	CDD:214564	11/63 (17%)
		VWD	371..536	CDD:214566	42/169 (25%)
		C8	580..646	CDD:285899	19/68 (28%)
MUC2	NP_002448.4	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910