DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cv-2 and crim1

DIOPT Version :9

Sequence 1:NP_524809.2 Gene:cv-2 / 45280 FlyBaseID:FBgn0000395 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_997986.1 Gene:crim1 / 404210 ZFINID:ZDB-GENE-040312-2 Length:1027 Species:Danio rerio


Alignment Length:511 Identity:132/511 - (25%)
Similarity:180/511 - (35%) Gaps:151/511 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 GVRQSCSNEGEEVQLK----NQPQIFTCFKCECQNGFVNCRD-TCPPVNDC---YILDKSN-GTC 116
            |:..||:       ||    .|..|..|..|:|:.....|:. .|  ..||   ||.:|.. .||
Zfish   501 GLMASCT-------LKCPFGFQTDIHGCDVCQCRPRHKKCKAVAC--AKDCPFGYIKNKHGCDTC 556

  Fly   117 -CRRCK-----------------GC-----------------------SFRGMSYESGSEWNDPE 140
             |::|.                 ||                       |..|..:|:|..|:   
Zfish   557 RCKKCPELPCDKACPMGFQHDELGCLICQCRDQSSSSVTPAVKLGSCLSMDGRRHENGQSWH--- 618

  Fly   141 DPCKTYKCVATVVTETIQKC-YSQCDNNQLQPPRPGECCPTC--------------QGCKI-NGQ 189
            |.|:...|.|......:..| ...|||..:   |||.|||||              ..|.. .|:
Zfish   619 DGCRDCYCHAGREMCALISCPVPPCDNPTI---RPGHCCPTCPEESSSHKPELSEASVCLAPGGE 680

  Fly   190 TVAEGHEVDASIDDRCLVCQCRGTQLTCSKKTCPVLPCPMSKQIKRPDECCPRCPQNHSFLPVPG 254
            ...||...:.   |.|..|.|...::.|..:.||.|.|  ...|:..|.|||.||.:    ||..
Zfish   681 YFVEGETWNI---DSCTQCTCHSGRVLCETEVCPPLLC--HSPIRTQDSCCPHCPDD----PVTP 736

  Fly   255 KCLFNKS-----------VYPEKTQFMPDRCTNCTCLNGTSVCQRPTCPILECAPEFQEPDGCCP 308
            :...|.|           ::.....:.|:.|::|.||:|...|...:||.:.||........|||
Zfish   737 QTPSNDSMPSYCRNEDGDIFLAAESWKPNVCSSCVCLDGAISCFSESCPPVNCARPVLRKGQCCP 801

  Fly   309 RCAVAEVRSECSLDGIVYQNNETWDMGPCRSCRCNGGTIRCAQMRCPAVKCRANEELKQP---PG 370
            .|..|..|:.|..:|..|.:.|.||:..|..|.|..|...|:.:.|||:.|.      ||   .|
Zfish   802 YCLDATPRAVCHFNGKTYMDEERWDIDSCTHCYCLQGQTLCSTVSCPALPCH------QPLTVEG 860

  Fly   371 ECCQRCVETAGTCTV-------FGD-----------------PHFRTFDGKFFSFQGSCKYLLAS 411
            .||..|.|:.....|       .||                 |.||   |:|.|.|  ..||   
Zfish   861 SCCPMCPESYAPTNVPIEKTDQRGDKSRHQPAWPTHSENDVMPQFR---GEFGSLQ--MPYL--- 917

  Fly   412 DCMGKTFHIRLTNEGRGTRRASWAKTVTLSLRNLKVNLGQRMRVKVNGTRVTLPYF 467
              .|||   .|.:|..|..   || .|.|.:..:.:.|...:.|......:.:|.:
Zfish   918 --DGKT---PLPSEDAGLH---WA-WVALPVLMMMLTLAALLLVNQRKQWIPVPCY 964

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cv-2NP_524809.2 VWC 184..243 CDD:214564 18/59 (31%)
VWC 256..310 CDD:278520 16/64 (25%)
VWC 319..376 CDD:214564 20/59 (34%)
VWD 371..536 CDD:214566 29/121 (24%)
C8 580..646 CDD:285899
crim1NP_997986.1 IGFBP 33..84 CDD:278641
Cell attachment site. /evidence=ECO:0000255 308..310
VWC 330..384 CDD:214564
VWC 397..450 CDD:302663
Antistasin 561..586 CDD:280912 3/24 (13%)
VWC 607..657 CDD:302663 18/55 (33%)
VWC 678..729 CDD:302663 17/55 (31%)
VWC 751..803 CDD:302663 14/51 (27%)
VWC 812..866 CDD:302663 20/59 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 877..897 2/19 (11%)
Cell attachment site. /evidence=ECO:0000255 883..885 0/1 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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