DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cv-2 and VWC2

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_940972.2	Gene:	VWC2 / 375567	HGNCID:	30200	Length:	325	Species:	Homo sapiens

Alignment Length:	167	Identity:	47/167 - (28%)
Similarity:	65/167 - (38%)	Gaps:	28/167 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 PRCPQNHSFLPVPGKCLFNKS--VYP--EKTQFMPDRCTNCTCLNGTSVCQRPTCPILECAPEFQ 301
            |..|:.:.:....||...::|  ||.  ||....|..|. |.|.....:|.:|.||.|.......
Human   139 PEPPEEYVYPDYRGKGCVDESGFVYAIGEKFAPGPSACP-CLCTEEGPLCAQPECPRLHPRCIHV 202

  Fly   302 EPDGCCPRCAVAEVRSECSLDGIVYQNNETWDMGPCRSCRCN-GGTIRCAQMRCPAVKCRANEEL 365
            :...|||:|  .|.::.|...|..||..|.:.:.||..|||. .|.:.|....||..:|   .:.
Human   203 DTSQCCPQC--KERKNYCEFRGKTYQTLEEFVVSPCERCRCEANGEVLCTVSACPQTEC---VDP 262

  Fly   366 KQPPGECCQRC-------VETA----------GTCTV 385
            ...|.:||..|       .|||          ..||:
Human   263 VYEPDQCCPICKNGPNCFAETAVIPAGREVKTDECTI 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	1/1 (100%)
		VWC	256..310	CDD:278520	17/57 (30%)
		VWC	319..376	CDD:214564	18/57 (32%)
		VWD	371..536	CDD:214566	8/32 (25%)
		C8	580..646	CDD:285899
VWC2	NP_940972.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	37..121
		Mediates cell adhesion. /evidence=ECO:0000250	114..116
		VWC	218..273	CDD:327433	18/57 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870