DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cv-2 and OTOG

DIOPT Version :10

Sequence 1:NP_524809.2 Gene:cv-2 / 45280 FlyBaseID:FBgn0000395 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_001264198.1 Gene:OTOG / 340990 HGNCID:8516 Length:2925 Species:Homo sapiens


Alignment Length:686 Identity:169/686 - (24%)
Similarity:247/686 - (36%) Gaps:194/686 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 EGE--EVQLKNQPQI----FTCFKC---------------ECQNGFVNCRDTCPPVNDC------ 106
            ||:  .:|:.|.||.    :||.:.               |..:|  ..|...|.|...      
Human   185 EGQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQEIHLAKEVTHG--GMRVQLPHVMGSARLQQL 247

  Fly   107 --YILDKSNGTCCRRCKGCS--FRGMSYE--------SGSEWNDPEDPCKTYKCVAT-VVTETIQ 158
              |::.:..........|.|  :..||.|        .|:...||:|...|.....| .|.|.:.
Human   248 AGYVIVRHQSAFTLAWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGKLTDDVVEFVH 312

  Fly   159 KCYSQCDNNQLQPPRPGECC---PTCQGCKINGQTVAEGHEVDASIDDRCLVCQCRGTQLTCSKK 220
            ....|..|   |||.|....   |.|  .:.|..|:...:|            ||...       
Human   313 SWQEQAPN---QPPGPTTSSLPRPPC--LQQNPGTMQGVYE------------QCEAL------- 353

  Fly   221 TCPVLPCPMSKQIKRPDECCPRCPQNHSFL-PVPGKCLFNKSVYPEKTQFMPDRCTNCTCL---- 280
                        ::.|.:.|      |::: |:|    |..|...:..|.|.|..|.|..|    
Human   354 ------------LRPPFDAC------HAYVSPLP----FTASCTSDLCQSMGDVATWCRALAEYA 396

  Fly   281 NGTSVCQRP-----------TCPILECAPEFQEPDGCCPRCAVAEVRSEC------SLDGIVYQN 328
            ...:...||           |....|.|..:.|...|||  |....|:.|      .:||....|
Human   397 RACAQAGRPLQGWRTQLRQCTVHCKEKAFTYNECIACCP--ASCHPRASCVDSEIACVDGCYCPN 459

  Fly   329 NETWDMGPCRSCRCNGGTIRCAQMRCPAVKCRANEELKQPPG----ECCQRCVETAG-------- 381
            ...::.|.|           .|...||   |..:..| .|||    |.|..|..|:|        
Human   460 GLIFEDGGC-----------VAPAECP---CEFHGTL-YPPGSVVKEDCNTCTCTSGKWECSTAV 509

  Fly   382 ---TCTVFGDPHFRTFDGKFFSFQGSCKYLLASDCMGKTFHIRLTNEGRGTRRASWAKTVTLSLR 443
               .|:|.||.||.||||:.::|..:|:|:||......||.:.|.|...|..:..      ..::
Human   510 CPAECSVTGDIHFTTFDGRRYTFPATCQYILAKSRSSGTFTVTLQNAPCGLNQDG------ACVQ 568

  Fly   444 NLKVNLGQRMRVKVNGT-----------RVTLPY----FVVAGGQNVTIERLANGGAVMLRSEMG 493
            ::.|.|.|..|.:|..|           ::..||    |.:....:|.:....|.|..:|....|
Human   569 SVSVILHQDPRRQVTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREG 633

  Fly   494 LTLEWNGAGFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTGKDGRSHGDDEVWHFANSWKVGGPKS 558
            |.|      :|||.  .::.:...||||.|||:::||.....|......::  |.||||.  ..:
Human   634 LRL------YLQVD--QRWVEDTVGLCGTFNGNTQDDFLSPVGVPESTPQL--FGNSWKT--LSA 686

  Fly   559 CSRKREFLAATP--TCD--KRKSNFYCHPLSV--PALFGECNERLNPENYKAACRMDVCECPSGD 617
            ||   ..::.:|  .||  .:.:::.....||  ..:|..|:..|:|..|...||.|.|.| ...
Human   687 CS---PLVSGSPLDPCDVHLQAASYSVQACSVLTGEMFAPCSAFLSPVPYFEQCRRDACRC-GQP 747

  Fly   618 CHCDSFAAYAHECRRLGVQLPDWRS-----ATNCPA 648
            |.|.:.|.|||.|||.|:.: |:|:     |.:|.|
Human   748 CLCATLAHYAHLCRRHGLPV-DFRARLPACALSCEA 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cv-2NP_524809.2 VWC 184..243 CDD:214564 7/58 (12%)
VWC 256..310 CDD:278520 17/68 (25%)
VWC 319..376 CDD:214564 16/66 (24%)
VWD 371..536 CDD:214566 53/190 (28%)
C8 580..646 CDD:462584 25/72 (35%)
OTOGNP_001264198.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 39..69
VWD 152..302 CDD:459671 24/118 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 316..335 7/21 (33%)
C8 349..412 CDD:462584 17/91 (19%)
TIL 426..474 CDD:460351 13/60 (22%)
VWC_out 476..>511 CDD:214565 10/35 (29%)
VWD 514..669 CDD:459671 48/168 (29%)
C8 713..767 CDD:462584 22/54 (41%)
TIL 780..844 CDD:410995 2/3 (67%)
TIL 884..946 CDD:410995
VWD 977..1131 CDD:214566
C8 1166..1240 CDD:214843
beta-trefoil_ABD_OTOG 1245..1396 CDD:467810
PHA03247 <1476..2041 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1476..1540
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1636..1679
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1693..1715
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1737..1788
VWD 2112..2266 CDD:459671
C8 2304..2370 CDD:214843
TIL 2373..2434 CDD:460351
Rossmann-fold NAD(P)(+)-binding proteins <2676..2736 CDD:473865
CT 2842..2924 CDD:214482
Blue background indicates that the domain is not in the aligned region.

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