DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cv-2 and OTOG

DIOPT Version :9

Sequence 1:NP_524809.2 Gene:cv-2 / 45280 FlyBaseID:FBgn0000395 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_001264198.1 Gene:OTOG / 340990 HGNCID:8516 Length:2925 Species:Homo sapiens


Alignment Length:686 Identity:169/686 - (24%)
Similarity:247/686 - (36%) Gaps:194/686 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 EGE--EVQLKNQPQI----FTCFKC---------------ECQNGFVNCRDTCPPVNDC------ 106
            ||:  .:|:.|.||.    :||.:.               |..:|  ..|...|.|...      
Human   185 EGQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQEIHLAKEVTHG--GMRVQLPHVMGSARLQQL 247

  Fly   107 --YILDKSNGTCCRRCKGCS--FRGMSYE--------SGSEWNDPEDPCKTYKCVAT-VVTETIQ 158
              |::.:..........|.|  :..||.|        .|:...||:|...|.....| .|.|.:.
Human   248 AGYVIVRHQSAFTLAWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGKLTDDVVEFVH 312

  Fly   159 KCYSQCDNNQLQPPRPGECC---PTCQGCKINGQTVAEGHEVDASIDDRCLVCQCRGTQLTCSKK 220
            ....|..|   |||.|....   |.|  .:.|..|:...:|            ||...       
Human   313 SWQEQAPN---QPPGPTTSSLPRPPC--LQQNPGTMQGVYE------------QCEAL------- 353

  Fly   221 TCPVLPCPMSKQIKRPDECCPRCPQNHSFL-PVPGKCLFNKSVYPEKTQFMPDRCTNCTCL---- 280
                        ::.|.:.|      |::: |:|    |..|...:..|.|.|..|.|..|    
Human   354 ------------LRPPFDAC------HAYVSPLP----FTASCTSDLCQSMGDVATWCRALAEYA 396

  Fly   281 NGTSVCQRP-----------TCPILECAPEFQEPDGCCPRCAVAEVRSEC------SLDGIVYQN 328
            ...:...||           |....|.|..:.|...|||  |....|:.|      .:||....|
Human   397 RACAQAGRPLQGWRTQLRQCTVHCKEKAFTYNECIACCP--ASCHPRASCVDSEIACVDGCYCPN 459

  Fly   329 NETWDMGPCRSCRCNGGTIRCAQMRCPAVKCRANEELKQPPG----ECCQRCVETAG-------- 381
            ...::.|.|           .|...||   |..:..| .|||    |.|..|..|:|        
Human   460 GLIFEDGGC-----------VAPAECP---CEFHGTL-YPPGSVVKEDCNTCTCTSGKWECSTAV 509

  Fly   382 ---TCTVFGDPHFRTFDGKFFSFQGSCKYLLASDCMGKTFHIRLTNEGRGTRRASWAKTVTLSLR 443
               .|:|.||.||.||||:.::|..:|:|:||......||.:.|.|...|..:..      ..::
Human   510 CPAECSVTGDIHFTTFDGRRYTFPATCQYILAKSRSSGTFTVTLQNAPCGLNQDG------ACVQ 568

  Fly   444 NLKVNLGQRMRVKVNGT-----------RVTLPY----FVVAGGQNVTIERLANGGAVMLRSEMG 493
            ::.|.|.|..|.:|..|           ::..||    |.:....:|.:....|.|..:|....|
Human   569 SVSVILHQDPRRQVTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREG 633

  Fly   494 LTLEWNGAGFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTGKDGRSHGDDEVWHFANSWKVGGPKS 558
            |.|      :|||.  .::.:...||||.|||:::||.....|......::  |.||||.  ..:
Human   634 LRL------YLQVD--QRWVEDTVGLCGTFNGNTQDDFLSPVGVPESTPQL--FGNSWKT--LSA 686

  Fly   559 CSRKREFLAATP--TCD--KRKSNFYCHPLSV--PALFGECNERLNPENYKAACRMDVCECPSGD 617
            ||   ..::.:|  .||  .:.:::.....||  ..:|..|:..|:|..|...||.|.|.| ...
Human   687 CS---PLVSGSPLDPCDVHLQAASYSVQACSVLTGEMFAPCSAFLSPVPYFEQCRRDACRC-GQP 747

  Fly   618 CHCDSFAAYAHECRRLGVQLPDWRS-----ATNCPA 648
            |.|.:.|.|||.|||.|:.: |:|:     |.:|.|
Human   748 CLCATLAHYAHLCRRHGLPV-DFRARLPACALSCEA 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cv-2NP_524809.2 VWC 184..243 CDD:214564 7/58 (12%)
VWC 256..310 CDD:278520 17/68 (25%)
VWC 319..376 CDD:214564 16/66 (24%)
VWD 371..536 CDD:214566 53/190 (28%)
C8 580..646 CDD:285899 25/72 (35%)
OTOGNP_001264198.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 39..69
VWD 152..302 CDD:278521 24/118 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 316..335 7/21 (33%)
C8 348..412 CDD:285899 18/104 (17%)
TIL 426..474 CDD:280072 13/60 (22%)
VWC_out 476..>511 CDD:214565 10/35 (29%)
VWD 503..668 CDD:214566 48/178 (27%)
C8 711..770 CDD:285899 23/60 (38%)
TIL 780..844 CDD:280072 2/3 (67%)
TIL 884..946 CDD:280072
VWD 977..1131 CDD:214566
C8 1166..1240 CDD:214843
Fascin <1305..>1370 CDD:304938
DUF4696 1473..1987 CDD:292395
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1476..1540
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1636..1679
E_Pc_C <1639..1720 CDD:284226
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1693..1715
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1737..1788
HrpB2 1953..>2040 CDD:305050
VWD 2112..2266 CDD:278521
C8 2304..2370 CDD:214843
TIL 2373..2434 CDD:280072
NADB_Rossmann <2676..2736 CDD:304358
CT 2842..2924 CDD:214482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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