DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-2 and Kcp

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_011239372.1	Gene:	Kcp / 333088	MGIID:	2141640	Length:	2120	Species:	Mus musculus

Alignment Length:	874	Identity:	223/874 - (25%)
Similarity:	304/874 - (34%)	Gaps:	314/874 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 CSNEGEEVQLKNQPQIF----TCFKCECQNGFVNC-RDTCPPV--------------NDCYILDK 111
            |...|..|.:::|...|    .|.:|.|.:|.|:| |.||||.              :.|....|
Mouse   697 CPQSGNMVPVRHQEHFFQPGDPCSRCLCLDGSVSCQRLTCPPAPCAHPRRDACCPSCDGCLYQGK 761

  Fly   112 ----------------------------------------SNGTCCRRCKGCSFRGMSYESGSEW 136
                                                    :...||..|..|.:.|:||.|..|:
Mouse   762 EFASGERFPSPNVACHVCLCWEGSVKCEPRTCAPAQCPFPTREDCCPACDSCDYLGVSYLSSQEF 826

  Fly   137 NDPEDPCKTYKCVATVVTETIQKCYSQCDNNQLQPPR-------PGECCPTCQGCKINGQTVAEG 194
            .||.:.|....|:...||.|.:.|         :||.       |..||||||||..:|.|.|.|
Mouse   827 PDPREACNLCTCLGGFVTCTRRPC---------EPPACSHPLIVPEHCCPTCQGCLYHGITAALG 882

  Fly   195 HEVDASIDDRCLVCQCRGTQLTCSKKTCPVLPC-------------------------------- 227
            ..:...:|..|.:|.|....:.|.||.||..||
Mouse   883 ETLPDPLDPTCSLCTCEEGSMRCQKKPCPPAPCAHPSPGPCFCPVCRSCLSQGREHQDGEEFEGP 947

  Fly   228 ------------------------PMSKQIKRPDECCPRC----------PQNHSFLPVP---GK 255
                                    |...|:..|..|||||          |:..|::|..   ..
Mouse   948 EGSCERCRCLAGQVSCTRLQCPSLPCLHQVTEPGTCCPRCTGCLARGEEHPEGSSWVPADSPCSS 1012

  Fly   256 CLFNKSV---------------------------------------------------------- 262
            |:.:|.:
Mouse  1013 CMCHKGIITCAQVQCVSACIWPQEGPSDCCPQCSGCEHGGRKYEPGESFQPGADPCEVCICKEQA 1077

  Fly   263 --------------YP---EKTQF----------------------------------------- 269
                          ||   |:..|
Mouse  1078 DMPTAPKDMGVADRYPGAREQLAFHSLGLSSVHSCCSRSVRGLPAFTVVGGSAPAWWAAHQASFF 1142

  Fly   270 -----------------------------MPDRCTNCTCLNGTSVCQRPTCPILECAPEFQE--- 302
                                         .||.|..|.|.:.|.:|....||.|.| |.::.
Mouse  1143 LLAPSTAVPPVPVKALSNCTEDLVGSELVPPDPCYTCQCQDLTWLCTHRACPELSC-PLWERHTT 1206

  Fly   303 PDGCCPRCAVAEVRSECSLDGIVYQNNETWDMGPCRSCRCNGGTIRCAQMRCPAVKCRANEELKQ 367
            |..|||.|  .:....|...|....:.|.|.:..|.||.|..||:.|...||..:.|..:|....
Mouse  1207 PGSCCPVC--KDPTQSCMHQGRWVASGEQWAVDACTSCSCVAGTVHCQTQRCRKLACSRDEVPAL 1269

  Fly   368 PPGECCQRCVETAGTCTVFGDPHFRTFDGKFFSFQGSCKYLLASDCMGKTFHIRLTNEGRGTRRA 432
            .||.||.||:....:|..|||||:|||||:...|||||.|:||.||.|:.|.:.:||:.||.|..
Mouse  1270 SPGSCCLRCLPRPASCMAFGDPHYRTFDGRLLHFQGSCSYVLAKDCHGEDFSVHVTNDDRGRRGV 1334

  Fly   433 SWAKTVTLSLRNLKVNLGQRMRVKVNGTRVTLPYFVVAGGQNVTIERLANGGAVMLRSEMGLTLE 497
            :|.:.|.:.|..:.|.|.|...|.|:...||||:.     :...:.....|..|:|.::.||.:.
Mouse  1335 AWTQEVAVLLGTVAVRLLQGRTVMVDQHTVTLPFL-----REPLLYIELRGHTVILHAQPGLQVL 1394

  Fly   498 WNGAGFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTGKDGRSHGDDEVWHFANSWKV------GGP 556
            |:|...::|.||:.::.:.|||||||||.::|||.|.|||....:.  .|.|||||      |.|
Mouse  1395 WDGQSQVEVRVPSSYRGQTCGLCGNFNGFAQDDLQGPDGRLLPTEA--SFGNSWKVPKGLGPGRP 1457

  Fly   557 KSCSRKREFLAATPTCDKRKSNFYCHPLSVPALFGECNERLNPENYKAACRMDVCECPSGD---- 617
            .|..|:.:...|.....:|::|..|..|.. :.|..|:..:.||.:.|||..|:|.|..|.
Mouse  1458 CSAGREVDPCRAAGYRARREANARCGILKT-SPFSHCHAVVPPEPFFAACVYDLCACGPGSSSDT 1521

  Fly   618 CHCDSFAAYAHECRRLGVQLPDWRSATNC 646
            |.||:..|||..||:.|| .|.||..|.|
Mouse  1522 CLCDALEAYASHCRQAGV-TPVWRGPTLC 1549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	22/114 (19%)
		VWC	256..310	CDD:278520	22/201 (11%)
		VWC	319..376	CDD:214564	19/56 (34%)
		VWD	371..536	CDD:214566	67/164 (41%)
		C8	580..646	CDD:285899	27/69 (39%)
Kcp	XP_011239372.1	VWC	166..220	CDD:278520
		VWC	224..280	CDD:327433
		VWC	285..341	CDD:327433
		VWC	344..399	CDD:327433
		VWC	458..514	CDD:278520
		VWC	517..573	CDD:327433
		VWC	634..690	CDD:327433
		VWC	<717..753	CDD:327433	11/35 (31%)
		VWC	931..987	CDD:327433	6/55 (11%)
		VWC	<1173..1214	CDD:214564	16/41 (39%)
		VWC	1221..1278	CDD:214564	19/56 (34%)
		VWD	1285..1432	CDD:365869	63/151 (42%)
		C8	1482..1549	CDD:370094	27/68 (40%)
		Glutenin_hmw	<1757..>1975	CDD:367362
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4929
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46698
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5817
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940