DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-2 and Muc5b

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_038957199.1	Gene:	Muc5b / 309114	RGDID:	1561983	Length:	3925	Species:	Rattus norvegicus

Alignment Length:	839	Identity:	203/839 - (24%)
Similarity:	286/839 - (34%)	Gaps:	281/839 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 TGFRPSTQLLILIAVLLAL----------LQGRTVDAGAGD--SLSGV--------------RQS 65
            ||.:...||:..:.|.:.|          |.|......|.|  :||||              :.|
  Rat   536 TGLQLQVQLVPFMQVFVRLDRSYQGQMCGLCGNFNQNQADDFTALSGVVEGTGAAFSNTWKTQAS 600

  Fly    66 CSNE--------GEEVQLKNQPQIFTCFKCECQNGFVNCRDTCPPV---NDCYILDKSNGTCCRR 119
            |.|.        ...|:.:|..:.:.....|....|..|..|..||   ::| :.|..|......
  Rat   601 CPNSKNTYEDPCSYSVENENFAREWCSMLTESSGVFSACHATVSPVPFYSNC-LFDTCNCENSED 664

  Fly   120 C---------KGCSFRGMSYESGSEWNDPEDPCKTYKCVATVVTETIQKCYSQCDNNQLQPPRPG 175
            |         :.|:.:|:..   |.|..                   :.||...:|    .|:..
  Rat   665 CMCAALSSYVRACAAKGVLL---SGWRG-------------------KACYKYMNN----CPQTK 703

  Fly   176 E-------CCPTCQGCKINGQTVAEGHEVDASIDDRCLVCQCRGTQLTCSKKTCPV--LPCPMSK 231
            |       |.|||:...          |||                :|||....||  ..||...
  Rat   704 EYSYSVSTCQPTCRSLS----------EVD----------------VTCSIPFVPVDGCTCPEGT 742

  Fly   232 QIKRPDECCP--RCPQNHSFLPVPGKCLFNKSVYPEKTQFMPDRCTNCTCLNGTSVC-----QRP 289
            .:...|.|.|  .||           |.|:.:|.......| |....|:|.||...|     ||.
  Rat   743 FLNDKDHCVPVEECP-----------CYFHGTVVASGEVVM-DNGVVCSCTNGKLTCLGALMQRN 795

  Fly   290 TCPILECAPEFQEPDGCCPRCAVAEVRSECSLDGIVYQNNETWDMGPCRSCRC------------ 342
            .    ||.......|  |...:|.:..:||      .::..|.|: .|.|.:|
  Rat   796 K----ECQAPMVYLD--CNNASVGDHGAEC------LRSCHTLDV-DCFSTQCVSGCVCPSGLVA 847

  Fly   343 --NGGTIRCAQMRCPAVKCRANEELKQPPGEC----CQRCV-----------ETAGTCTVFGDPH 390
              |||.|  |:..||.|    :.|....|||.    |..|.           ...|.|..:||.|
  Rat   848 DGNGGCI--AEEDCPCV----HNEATYRPGEIIRVDCNNCTCRNRRWECTNQPCMGACVAYGDGH 906

  Fly   391 FRTFDGKFFSFQGSCKYLLASD-CMGK-----TFHIRLTNEGRGTRRASWAKTVTLSLRNLKVNL 449
            |.||||:.:.|:|:|:|.||.| |.|.     ||.|...|...||...:.:|.:.:.:.:.::.|
  Rat   907 FVTFDGERYIFEGNCEYTLAQDYCRGNTSTDGTFRIVTENVPCGTTGTTCSKAIKIFVESYELIL 971

  Fly   450 GQ-RMRVKVNGTRVTLPYFVVAGGQNVTIERLANGGAVMLRSEMGLTLEWNGAGFLQVSVPAKFK 513
            .: ..:|...|.....||.:...|..:.||         :||  |:.:.|:....:.|.:...:|
  Rat   972 HEGNFKVVARGPSGDPPYKIRYMGIFLVIE---------IRS--GIVVSWDRKTSVFVRLQQHYK 1025

  Fly   514 KRLCGLCGNFNGSSRDDLTGKDGRSHGDDEVWHFANSWKVGGPKSCSRKREFLAATPTC------ 572
            .|:|||||||:.::.:|.|.:.....||  |..|.||||.               :|:|
  Rat  1026 GRVCGLCGNFDDNAINDFTTRSQSVVGD--VLEFGNSWKF---------------SPSCPDAPVP 1073

  Fly   573 -DKRKSNFY--------CHPLSVPALFGECNERLNPENYKAACRMDVCECPSG---DCHCDSFAA 625
             |...:|.|        |..:: .|.|..|:.:::...|..||..|||.|.||   :|.|.:.||
  Rat  1074 KDPCIANPYRKSWAQKKCSIIN-SATFAACHSQVDSTKYYEACVHDVCACDSGGDCECFCTAVAA 1137

  Fly   626 YAHECRRLGVQLPDWRSATNCPAGWRRNATLSSFKGNQF--YGDPSFSRMKGRRQKNHQLRLQLQ 688
            ||..||.:||.| .||:...||.               |  |.:|            |.   |.:
  Rat  1138 YAQACRDVGVCL-SWRTPDICPL---------------FCDYYNP------------HG---QCE 1171

  Fly   689 QEQQQRSKQGQKGRHKPGGHNQLDRQGHNGLDKDQLQKEFILKHVPSSFLYPRAPDRTP 747
            ...|.......|....|.||..:|..|..|                   .||:.|...|
  Rat  1172 WHYQPCGAPCLKTCRNPSGHCLVDLPGLEG-------------------CYPQCPPSQP 1211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	13/62 (21%)
		VWC	256..310	CDD:278520	16/58 (28%)
		VWC	319..376	CDD:214564	19/74 (26%)
		VWD	371..536	CDD:214566	53/186 (28%)
		C8	580..646	CDD:285899	27/76 (36%)
Muc5b	XP_038957199.1	VWD	80..227	CDD:214566
		C8	265..329	CDD:400886
		TIL	333..389	CDD:396409
		VWC_out	391..>436	CDD:214565
		VWD	418..582	CDD:214566	11/45 (24%)
		C8	619..688	CDD:214843	14/72 (19%)
		TIL	699..756	CDD:410995	19/82 (23%)
		TIL	798..859	CDD:410995	16/71 (23%)
		VWD	888..1047	CDD:214566	50/169 (30%)
		C8	1084..1158	CDD:214843	26/75 (35%)
		Mucin2_WxxW	1346..1432	CDD:404246
		PHA03255	1473..>1574	CDD:165513
		Mucin2_WxxW	1578..1666	CDD:404246
		Herpes_BLLF1	<1696..1888	CDD:282904
		Mucin2_WxxW	1892..1980	CDD:404246
		Mucin2_WxxW	2083..2171	CDD:404246
		Herpes_BLLF1	<2191..2449	CDD:282904
		Herpes_BLLF1	<2323..2742	CDD:282904
		Mucin2_WxxW	2458..2546	CDD:404246
		Mucin2_WxxW	2741..2829	CDD:404246
		Mucin2_WxxW	2903..2991	CDD:404246
		VWD	3237..3409	CDD:214566
		C8	3462..3524	CDD:400886
		TIL	3532..3585	CDD:396409
		VWC	3695..3756	CDD:214564
		CT	3833..3915	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11038
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910