DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-2 and Crim1

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001162574.1	Gene:	Crim1 / 298744	RGDID:	1308710	Length:	1037	Species:	Rattus norvegicus

Alignment Length:	783	Identity:	156/783 - (19%)
Similarity:	229/783 - (29%)	Gaps:	309/783 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 CSNEGEEVQLKNQPQIF--------TCFKCECQNGFVNC-RDTCPPVNDCYILDKSNGTCCRRCK 121
            |.||.:...:.|..:.:        .|..|.||.|...| ...|..:| |.......|.||..|:
  Rat   328 CVNETKPACVFNSVEYYDGDMFRMDNCRFCRCQGGVSICFTAQCGELN-CERYYVPEGECCPVCE 391

  Fly   122 ----------GCSFRGMSYESGSEWNDPEDPCKTYKCV----ATVVTETIQKCYSQCDNNQLQPP 172
                      ||...|.....|..|.  ||.|...:|:    ..|.|...|.|        :.|.
  Rat   392 DPIYPFNNPAGCYANGQIRAHGDRWR--EDDCTFCQCINGEPHCVATACGQSC--------MHPV 446

  Fly   173 R-PGECCPTCQ----------------GCKINGQTVAEGHEVDASIDDRCLVCQCRGTQLTC--S 218
            : ||||||.|:                .|.:..:....|.::|   .:.|..|||:..:..|  .
  Rat   447 KVPGECCPVCEEPTYITIDPPACGELSNCTLKEKDCVYGFKLD---HNGCRTCQCKNREERCLAL 508

  Fly   219 KKTCPVLPCP-----------MSKQIKRPDEC------------------------CPRCPQ--- 245
            |:.| .|.||           :.:...||.:|                        |.:||:
  Rat   509 KRAC-TLDCPFGFLTDVHNCELCQCRPRPKKCRPTICDKFCPLGFLRNKHGCDICRCKKCPELPC 572

  Fly   246 -----------NHSFL-------------PV-PGKCLFNKSVYPEKTQFMPDRCTNCTCLNGTSV 285
                       :|..|             || .|.||.....:.:..:...|.|..|.|.||..:
  Rat   573 SKVCPLGFQEDSHGCLICKCREVPTSAGPPVLSGTCLSMDGHHHKNEESWHDGCRECYCHNGKEM 637

  Fly   286 CQRPTCPILECAPEFQEPDGCCPRCAVAEVRSECSLD---------GIVYQNNETWDMGPCRSCR 341
            |...|||:..|......|..|||.||...|..:..|.         |..:...|||::..|..|.
  Rat   638 CALITCPVPACGNPTIRPGQCCPSCADDFVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCT 702

  Fly   342 CNGGTIRCAQMRCPAVKCRANEELKQPPGECCQRCVETAGTCTVFGDP-------------HFRT 393
            |:.|.:.|....||.:.|: |....|  ..||.:|.|         ||             :.|.
  Rat   703 CHSGRVLCETEVCPPLLCQ-NPSRTQ--DSCCPQCTE---------DPLQPSTSHNESVPSYCRN 755

  Fly   394 FDGKFFSFQGSCKYLLASDCMGKTFHIRLTNEGRGTRRASWAKTVTLSLRNLKVNLGQRMRVKVN 458
            .:|..|....|.|..:.:.|:.....|...:|          ...:::.....:..||
  Rat   756 DEGDIFLAAESWKPDVCTSCVCMDSSISCYSE----------SCPSVACERPVLRKGQ------- 803

  Fly   459 GTRVTLPYFVVAGGQNVTIERLANGGAVMLRSEMGLTLEWNGAGFLQVSVPAKFKKRLCGLCGNF 523
                ..||                                    .|:.::|   ||.:|    :|
  Rat   804 ----CCPY------------------------------------CLEDTIP---KKVVC----HF 821

  Fly   524 NGSSRDDLTGKDGRSHGDDEVWHFANSWKVGGPKSCSRKREFLAATPTCDKRKSNFYCHPLSVPA 588
            :           |:::.|:|.|..         .||:.          |...:....|..:|.|.
  Rat   822 S-----------GKTYADEERWDI---------DSCTH----------CYCLQGQTLCSTVSCPP 856

  Fly   589 LFGECNERLNPENYKAACRMDVCECPSGDCHCDSFAAYAHECRRLGVQLPDWRSATNCPAGWRRN 653
            |  .|.|   |...:.:|      ||.              |..:.|..|     ||.|.
  Rat   857 L--PCAE---PIKVEGSC------CPM--------------CPEMYVPEP-----TNVPI----- 886

  Fly   654 ATLSSFKGNQFYGDPSFSRMKGRRQKNHQLRLQLQQEQQQRSKQGQKGRHKPG--GHNQLDRQGH 716
                                   .:|||:..:.|:........:... .|.|.  ||.|:|.:.:
  Rat   887 -----------------------EKKNHRGEIDLEVPMWPTPSENDI-IHLPRDMGHLQVDYRDN 927

  Fly   717 NGL 719
            |.|
  Rat   928 NRL 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	17/95 (18%)
		VWC	256..310	CDD:278520	17/53 (32%)
		VWC	319..376	CDD:214564	17/65 (26%)
		VWD	371..536	CDD:214566	24/177 (14%)
		C8	580..646	CDD:285899	14/65 (22%)
Crim1	NP_001162574.1	IB	37..>95	CDD:197525
		VWC	336..390	CDD:214564	13/54 (24%)
		VWC	403..456	CDD:214564	19/62 (31%)
		Antistasin	567..592	CDD:280912	4/24 (17%)
		VWC	612..662	CDD:302663	15/49 (31%)
		VWC	683..734	CDD:302663	16/53 (30%)
		VWC	758..808	CDD:302663	11/106 (10%)
		VWC	819..873	CDD:302663	19/112 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810