DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cv-2 and Kcp

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_038964921.1	Gene:	Kcp / 296952	RGDID:	1561119	Length:	1671	Species:	Rattus norvegicus

Alignment Length:	623	Identity:	222/623 - (35%)
Similarity:	303/623 - (48%)	Gaps:	61/623 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 GDSLSGVRQSCSNEGEEVQLKNQ---PQIFTCFKCECQNGFVNC-RDTCPPVNDCYILDKSNGTC 116
            |.....|.:||..:|:|.|...:   |: .:|.:|.|..|.|:| |..|||: .|.:.....|||
  Rat  1012 GPCFCPVCRSCLFQGQEHQDGEEFEGPE-GSCERCRCLAGQVSCMRLQCPPL-PCLLQATEPGTC 1074

  Fly   117 CRRCKGCSFRGMSYESGSEWNDPEDPCKTYKCVATVVTETIQKCYSQCDNNQLQPPR-PGECCPT 180
            |.||.||..||..:..||.|...:.||.:..|...:||....:|.|.|    :.|.: |.:|||:
  Rat  1075 CPRCTGCRVRGEEHPEGSSWVPADSPCSSCMCHKGIVTCAQVQCVSAC----IWPQQGPSDCCPS 1135

  Fly   181 CQGCKINGQTVAEGHEVDASIDDRCLVCQC----RG-TQLTCSKKTCP-VLPCPMSKQI-KRPDE 238
            |.||:..|:....|...... ||.|.||.|    :| ..|.|.::.|| ::.||.|:.: ..|..
  Rat  1136 CSGCEHEGRKYEPGESFQPG-DDPCEVCICELKGKGPPSLHCRRRQCPSLVGCPPSQLLPPGPQH 1199

  Fly   239 CCPRCPQNHSFLPVPGKC---LFNKSVYPEKTQFMPDRCTNCTCLNGTSVCQRPTCPILECAPEF 300
            |||.|.|..|      .|   |....:.|      ||.|..|.|.:.|.:|....||.|.| |.:
  Rat  1200 CCPACAQALS------NCTEDLLGSELVP------PDPCYTCQCQDLTWLCTHRACPALSC-PLW 1251

  Fly   301 QE---PDGCCPRCAVAEVRSECSLDGIVYQNNETWDMGPCRSCRCNGGTIRCAQMRCPAVKCRAN 362
            :.   |..|||.|  .:....||..|....:.|.|.:..|.||.|..||:.|...||..:.|..:
  Rat  1252 EHHTTPGSCCPVC--KDPTGSCSHQGRWVASGEHWIVDACTSCACVAGTVHCQSQRCRNLSCGRD 1314

  Fly   363 EELKQPPGECCQRCVETAGTCTVFGDPHFRTFDGKFFSFQGSCKYLLASDCMGKTFHIRLTNEGR 427
            |.....||.||.||:....:|..|||||:|||||:...|||||.|:||.||..:.|.:.:||:.|
  Rat  1315 EVPALSPGSCCPRCLPGLASCMAFGDPHYRTFDGRLLHFQGSCSYVLAKDCHSEDFSVHVTNDDR 1379

  Fly   428 GTRRASWAKTVTLSLRNLKVNLGQRMRVKVNGTRVTLPYFVVAGGQNVTIERLANGGAVMLRSEM 492
            |.|..:|.:.|.:.|..:.|.|.|...|.|:...||||:.     :...:.....|..|:|.::.
  Rat  1380 GRRGVAWTQEVAVLLGTVAVRLLQGRTVMVDQHTVTLPFL-----REPLLYIELRGHTVILHAQP 1439

  Fly   493 GLTLEWNGAGFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTGKDGRSHGDDEVWHFANSWKV---- 553
            ||.:.|:|...::|.||:.::.:.|||||||||.::|||.|.|||....:..  |.|||||
  Rat  1440 GLQVLWDGQSQVEVRVPSSYRGQTCGLCGNFNGFAQDDLQGPDGRLLPTEAA--FGNSWKVPKGL 1502

  Fly   554 --GGPKSCSRKREFLAATPTCDKRKSNFYCHPL-SVPALFGECNERLNPENYKAACRMDVCECPS 615
              |.|.|..|:.:...|.....:|::|..|..| |.|  |..|:..:.||.:.|||..|:|.|..
  Rat  1503 GPGRPCSAGREVDPCRAAGYRARREANARCGILKSSP--FSRCHAVVPPEPFFAACVYDLCACGP 1565

  Fly   616 GD----CHCDSFAAYAHECRRLGVQLPDWRSATNCPAG 649
            |.    |.||:..|||..||:.|| .|.||..|.|..|
  Rat  1566 GSSADTCLCDALEAYASHCRQAGV-TPVWRGPTLCVVG 1602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	21/65 (32%)
		VWC	256..310	CDD:278520	19/59 (32%)
		VWC	319..376	CDD:214564	20/56 (36%)
		VWD	371..536	CDD:214566	66/164 (40%)
		C8	580..646	CDD:285899	29/70 (41%)
Kcp	XP_038964921.1	VWC	227..281	CDD:278520
		VWC	285..341	CDD:327433
		VWC	405..460	CDD:327433
		VWC	608..664	CDD:327433
		VWC	725..781	CDD:327433
		VWC	1022..1078	CDD:327433	20/57 (35%)
		VWC	1139..1204	CDD:327433	21/65 (32%)
		VWC	<1223..1264	CDD:327433	16/41 (39%)
		VWC	1271..1328	CDD:327433	20/56 (36%)
		VWD	1335..1484	CDD:395046	63/153 (41%)
		C8	1527..1599	CDD:214843	30/74 (41%)
		TIL	1610..1663	CDD:410995
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4903
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104860at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46698
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920