Protein Alignment cv-2 and MUC19

DIOPT Version :10

• Sequence 1: NP_524809.2
• Gene: cv-2 / 45280
• FlyBaseID: FBgn0000395
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_775871.2
• Gene: MUC19 / 283463
• HGNCID: 14362
• Length: 8384
• Species: Homo sapiens
• Alignment Length: 621
• Identity: 149/621 - (23%)
• Similarity: 218/621 - (35%)
• Gaps: 177/621 - (28%)

  Fly    85 FKCECQNGFVNCRDT--------CPPVNDCYILDKSNGTCCRRC----------KGCSFRGMSYE 131
            :.|.|:|. .:|..|        |.. .:.||:....|.|...|          |.|:....|..
Human  1036 YTCTCENS-QDCLCTILGNYVKACAE-KETYIVGWRTGLCEHSCPSGLVFKYNVKACNSSCRSLS 1098

  Fly   132 SGSEWNDPED-PCKTYKCVATVVTETIQKCY--SQCDNNQLQPPRPGECCPTCQGCKINGQTVAE 193
            ......|.|| |.....|...:.......|.  ||||                  |.||.:.:..
Human  1099 ERDRSCDVEDVPVDGCTCPDAMYQNNEGNCVLKSQCD------------------CYINDEVMQP 1145

  Fly   194 GHEVDASIDDRCLVCQCRGTQLTC------SKKTC----PVLPCPMSKQIKRPDECCPRCPQNHS 248
            |..:  .|||.  .|.||...|.|      :.:.|    ..:.|...|..:|.:..|       |
Human  1146 GKLI--HIDDN--KCVCRDGILLCQIPIDLTLQNCSGGAEYVDCSDPKAQRRTNRTC-------S 1199

  Fly   249 FLPVPGKCLFNKSVYPEKTQFMPDRCTNCTCLNGTSVCQRPT-CPILECAPEFQEPDGCCPRCAV 312
            ...:|   :|::::..::..|.|:....    |...:|..|. ||
Human  1200 TRNIP---VFDENLPCKRGCFCPEGMVR----NSKGICVFPNDCP-------------------- 1237

  Fly   313 AEVRSECSLDGIVYQNNETWDMGPCRSCRCNGGTIRCAQMRCPAVKCRANEELKQPPGECCQRCV 377
                  ||..|..|.......:| |..|.|..|:..|.|..|..:
Human  1238 ------CSFGGREYDEGSVTSVG-CNECTCIKGSWSCTQNECQTI-------------------- 1275

  Fly   378 ETAGTCTVFGDPHFRTFDGKFFSFQGSCKYLLASDCMGK---TFHIRLT------NEGRGTRRAS 433
                 |.::|:.|.||||||.:||.|.|:|....|..|.   ||.| ||      .:|
Human  1276 -----CHIYGEGHVRTFDGKSYSFDGLCQYSFLEDYCGHENGTFRI-LTESVPCCEDG------- 1327

  Fly   434 WAKTVTLSLRNLKVNLGQRMRVKVNGTRVTLPYFVVAGGQNVTIERLAN-------GGAVMLRSE 491
                :|.| |.:.|.. |...:.:...:||    .|...::...|..||       |..::|:.:
Human  1328 ----LTCS-RKIIVAF-QDQNIVLQDGKVT----AVKSTESKKCELNANAYSIHTVGLYLILKFQ 1382

  Fly   492 MGLTLEWNGAGFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTGKDGRSHGDDEVWHFANSWKVGGP 556
            .|:.:.|:....|.|.:...:..::||||||.||..:||.|.:  .|........|.||||..
Human  1383 NGIIVIWDKNTRLSVILDPNWNGKVCGLCGNNNGDLKDDFTTR--YSSVASGALEFGNSWKTS-- 1443

  Fly   557 KSCSRKREFLAATPTCDKRKSNFYCHPLSV-------PALFGECNERLNPENYKAACRMDVCECP 614
            :.||   :.:|.|..||   ||.||...:|       .:.|.:|:.:::|..|..||..:.|.|.
Human  1444 QECS---DTVAQTFPCD---SNPYCKAWAVRKCEILRDSTFRDCHNKVDPSAYHDACIEEACACD 1502

  Fly   615 SGDCH---CDSFAAYAHECRRLGVQLPDWRSATNCP 647
            ....:   |.:.|.||..|..:||.: .||....||
Human  1503 MEGKYLGFCTAVAMYAEACSAVGVCV-SWRKPNLCP 1537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	17/68 (25%)
		VWC	256..310	CDD:278520	8/54 (15%)
		VWC	319..376	CDD:214564	12/56 (21%)
		VWD	371..536	CDD:214566	50/180 (28%)
		C8	580..646	CDD:462584	20/75 (27%)
MUC19	NP_775871.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..197
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	222..247
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	279..305
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	332..467
		VWD	481..616	CDD:214566
		TIL	721..776	CDD:410995
		VWC	778..>814	CDD:450195
		VWD	806..968	CDD:214566
		C8	1006..1073	CDD:462584	9/38 (24%)
		TIL	1077..1134	CDD:410995	11/56 (20%)
		TIL	1176..1236	CDD:410995	13/73 (18%)
		VWC	1238..>1273	CDD:450195	11/35 (31%)
		VWD	1265..1425	CDD:214566	53/202 (26%)
		C8	1463..1537	CDD:214843	18/74 (24%)
		Hia	1636..2228	CDD:444098
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1680..1699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1732..2464
		FhaB	2054..3761	CDD:442443
		Approximate repeats of G-V-T-G-T-T-G-P-S-A. /evidence=ECO:0000305	2238..6086
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2484..2526
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2540..2827
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2850..2917
		FhaB	2950..4648	CDD:442443
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2984..3027
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3075..3368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3386..3428
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3585..3628
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3667..3736
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4105..4147
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4187..4251
		FhaB	4201..5895	CDD:442443
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4315..4390
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4414..4455
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4510..4583
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4790..4843
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4895..4930
		FhaB	5067..6771	CDD:442443
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	5130..5161
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	5429..5452
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	5464..5494
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	5880..5918
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	6069..6403
		FhaB	6415..8123	CDD:442443
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	6440..6918
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	6953..7223
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	7250..7749
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	7783..7975
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	8020..8133
		VWC	8161..8221	CDD:214564
		CT	8295..8376	CDD:214482