DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-2 and Sspo

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_017177063.1	Gene:	Sspo / 243369	MGIID:	2674311	Length:	5197	Species:	Mus musculus

Alignment Length:	653	Identity:	168/653 - (25%)
Similarity:	238/653 - (36%)	Gaps:	175/653 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 FKCECQNGFVNC---RDTCPPVNDCY---------ILDKSNGTCCR-RCKGCSFRGMSYES---- 132
            |:..|......|   ||...||...|         :|...|.|.|. .|.|    |..|:.
Mouse   818 FRLRCLEAVCGCAPGRDCLCPVLSAYTRHCAQEGVLLQWRNETLCPVSCPG----GQVYQECAPV 878

  Fly   133 -GSEWNDPEDPCKTYKCVATVVTETIQKCYSQCDNNQLQPP-----RPGECCP--TCQGCKINGQ 189
             |....:||| ||           .:..|.:.|:    .||     ..|:|.|  .|. |:..|.
Mouse   879 CGHHCGEPED-CK-----------ELGICVAGCN----CPPGLLWDLEGQCVPPSMCH-CQFGGH 926

  Fly   190 --TVAEGHEVDASIDDRCLVCQCRGTQLTCSKKTCPVLPCPMSKQIKRPDECCPRCPQNHSFLPV 252
              |:......|.|   .| :||.||. ..|:...||           |....|||     ..:.|
Mouse   927 RYTINTTTVRDCS---HC-ICQERGL-WNCTAHHCP-----------RQWALCPR-----ELIYV 970

  Fly   253 PGKCLF-------NKSVYPEKTQFMPDRCTNCTCLNGTSVCQRPTCPILECAPEFQEPDGCCPRC 310
            ||.||.       |.|.:...|.       .|.|..||.:..:      .|.    .|| .||
Mouse   971 PGACLLTCDSPRANHSCWAGSTD-------GCVCPPGTVLLDK------HCV----SPD-LCP-- 1015

  Fly   311 AVAEVRSECSLDGIVYQNNETWDMGPCRSCRCNGGTIRCAQMRCPAVKCRANEELKQPPGECCQR 375
                    |..:|..|..|.| ....|..|.|.|....|...||
Mouse  1016 --------CRHNGQWYPPNAT-IQEDCNICVCQGQRWHCTGQRC--------------------- 1050

  Fly   376 CVETAGTCTVFGDPHFRTFDGKFFSFQGSCKYLLASDCMGKTFHIRLTNEGRGTRRASWAKTVTL 440
                :|.|...|.||:.||||..|:|.|:|:|||..:..|: |.:.:.|...|....:..|.:.:
Mouse  1051 ----SGWCQASGAPHYVTFDGLVFTFPGACEYLLVREAGGR-FSVSVQNLPCGASGLTCTKALVV 1110

  Fly   441 SLRNLKVNLGQRMRVKVNGTRVTLPYFVVAGGQNVTIERLANGGAVMLRSEMGLTLEWNGAGFLQ 505
            .|.:..|::.:...|.|||..:.||  .|..|..:::...  |..::|.:.:||||.|:|...:.
Mouse  1111 RLDSTVVHMLRGQAVTVNGVSIRLP--KVYTGPGLSLHHA--GLFLLLTTRLGLTLLWDGGTRVL 1171

  Fly   506 VSVPAKFKKRLCGLCGNFNGSSRDDLTGKDGRSHGDDEVWHFANSWKVGG--------PKSCSRK 562
            |.:...|..|:.||||||:..:.:||..:.|......|:  .|:||::..        |..|
Mouse  1172 VQLSPHFHGRVAGLCGNFDSDASNDLRSRQGVLEPTAEL--TAHSWRLNPLCPEPGDLPHPC--- 1231

  Fly   563 REFLAATPTCDKRKSNF---YCHPLSVPALFGECNERLNPENYKAACRMDVCECPSG---DCHCD 621
                    |.:..::|:   .|..:..| :|..|:..:.|:.|...|..|.|.|.:|   :|.|.
Mouse  1232 --------TVNAHRANWARARCEVILQP-IFAPCHTEVPPQQYYEWCVYDACGCDTGGDCECLCS 1287

  Fly   622 SFAAYAHECRRLGVQLPDWRSATNCPAGWRRNATLSSFKGNQFYGDPSFSRMKGRRQKNH-QLRL 685
            :.|.||.||.|....: .|||...||.         ..:|.|.| :|..|........:| :||.
Mouse  1288 AIATYADECARHRHHV-RWRSQELCPL---------QCEGGQVY-EPCGSTCPPTCHDHHSELRW 1341

  Fly   686 QLQ 688
            ..|
Mouse  1342 HCQ 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	16/60 (27%)
		VWC	256..310	CDD:278520	14/60 (23%)
		VWC	319..376	CDD:214564	12/56 (21%)
		VWD	371..536	CDD:214566	50/164 (30%)
		C8	580..646	CDD:285899	22/68 (32%)
Sspo	XP_017177063.1	VWD	229..378	CDD:214566
		C8	434..505	CDD:370094
		TIL	509..564	CDD:366828
		VWD	593..753	CDD:214566
		C8	791..863	CDD:214843	11/44 (25%)
		TIL	866..919	CDD:366828	17/72 (24%)
		VWD	1054..1201	CDD:365869	49/151 (32%)
		C8	1245..1311	CDD:370094	22/67 (33%)
		TIL	1315..1371	CDD:366828	9/31 (29%)
		LDLa	1416..1451	CDD:238060
		LDLa	1456..1490	CDD:238060
		LDLa	1492..1526	CDD:238060
		LDLa	1532..1563	CDD:197566
		Ldl_recept_a	1603..1639	CDD:365841
		TSP1	1737..1788	CDD:214559
		TIL	1857..1908	CDD:366828
		TSP1	1952..2005	CDD:214559
		FA58C	<2142..2262	CDD:330301
		LDLa	2275..2309	CDD:238060
		LDLa	2414..2448	CDD:238060
		LDLa	2471..2505	CDD:238060
		TSP1	2565..2617	CDD:214559
		TIL	2640..2682	CDD:366828
		TSP1	2725..2774	CDD:214559
		TSP_1	2841..2889	CDD:365867
		TIL	2893..2952	CDD:366828
		VWC_out	2954..3001	CDD:214565
		TSP1	2994..3045	CDD:214559
		TIL	3097..3149	CDD:366828
		TSP1	3193..3256	CDD:214559
		TSP1	3262..3314	CDD:214559
		TIL	3322..3372	CDD:366828
		TSP1	3418..>3458	CDD:214559
		TSP1	3482..3526	CDD:214559
		TIL	3536..3592	CDD:366828
		TSP1	3655..3699	CDD:214559
		TSP1	3832..3884	CDD:214559
		TSP1	3901..3949	CDD:214559
		TSP1	3967..4020	CDD:214559
		TSP1	4025..4077	CDD:214559
		TIL	4080..4135	CDD:366828
		TSP1	4180..4230	CDD:214559
		TSP1	4274..4325	CDD:214559
		TSP1	4389..4440	CDD:214559
		TIL	4444..4499	CDD:366828
		TSP1	4639..4687	CDD:214559
		TIL	4701..4747	CDD:366828
		TSP1	4791..4840	CDD:214559
		TIL	4842..4896	CDD:366828
		TIL	4948..5006	CDD:366828
		VWC	5008..5063	CDD:327433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900