Protein Alignment cv-2 and Muc19

DIOPT Version :10

• Sequence 1: NP_524809.2
• Gene: cv-2 / 45280
• FlyBaseID: FBgn0000395
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_997126.2
• Gene: Muc19 / 239611
• MGIID: 2676278
• Length: 7524
• Species: Mus musculus
• Alignment Length: 656
• Identity: 151/656 - (23%)
• Similarity: 217/656 - (33%)
• Gaps: 234/656 - (35%)

  Fly   104 NDCYILDKSNG--TCCRRCKGCSFRGMSYESGSEWNDPEDPCKTYKCVATVVTETIQKCYSQCDN 166
            ::|.||..|:|  ..|.:.....|.             .:.||.|.|              .|:|
Mouse   582 SNCEILLSSSGPFAACHQTVNPKFY-------------HEECKKYTC--------------SCEN 619

  Fly   167 NQLQPPRPGECCPTCQGCKINGQTVAEGHEVDASI----DDRCLV--------------CQCRGT 213
            .|       :|.     |.:.|..|....|.:..:    |..|.|              |.....
Mouse   620 GQ-------DCL-----CTVLGNYVKACAEKEIYLVGWRDGLCEVSCPSGLVFNYKVKTCNSSCR 672

  Fly   214 QLTCSKKTCPVLPCPMSKQIKRPDECCPRCP----QNHSFLPVPGKCLFNKS----------VYP 264
            .|:...::|.:...|:       |.|  .||    ||:.     |.|: .||          |.|
Mouse   673 SLSARDRSCDIEDIPV-------DGC--TCPDGMYQNNE-----GNCV-QKSECDCYVNDEIVQP 722

  Fly   265 EKTQFMPDRCTNCTCLNGTSVCQRPTCPILE-----------------------CA----PEFQE 302
            .|:..:.|  ..|.|.:|...||.|....|:                       ||    |:| |
Mouse   723 GKSILIDD--NKCVCQDGVLHCQTPLDLTLQNCSRGAEYIDCKDPKAQRRTERTCATRNIPDF-E 784

  Fly   303 PDGCCPR---CAVAEVRSE-----------CSLDGIVYQNNETWDMGPCRSCRCNGGTIRCAQMR 353
            .|..|.|   |.|..||:.           ||.....|:......:| |..|.|..|:..|.|..
Mouse   785 GDLPCKRGCYCPVGMVRNSKGICIHPDDCPCSFGDREYEQGSVTSVG-CNECTCIKGSWNCTQNE 848

  Fly   354 CPAVKCRANEELKQPPGECCQRCVETAGTCTVFGDPHFRTFDGKFFSFQGSCKYLLASDCMGK-- 416
            |.:                         ||.|:|:.|||||||:.:||.|.|:|....|..|:
Mouse   849 CQS-------------------------TCHVYGEGHFRTFDGESYSFDGLCQYTFLEDYCGQEN 888

  Fly   417 -TFHIRLTNEGRGTRRASWAKTVTLSLRNLKVNLGQRMRVKVNGTRVTLPYFVVAGGQNVTI--- 477
             ||.|                            |.:.:....||...:....|....||:.:
Mouse   889 GTFRI----------------------------LIESVPCCENGLTCSRKVIVTFQDQNIILQDG 925

  Fly   478 --------------ERLAN-------GGAVMLRSEMGLTLEWNGAGFLQVSVPAKFKKRLCGLCG 521
                          ||.||       |..::::...|:.|.|:....:.|.:...::.::|||||
Mouse   926 KVTAVQTAESTDCRERSANLYSIHTVGLYLIVKLLNGIILIWDKYTKVSVILDPSWQNKVCGLCG 990

  Fly   522 NFNGSSRDDLTGKDGRSHGDDEVWHFANSWKVGGPKSCSRKREFLAATPTCDKRKSNFYCHPLSV 586
            |.||..:||.|.:  .|........||||||..  :.||   :.:..:..||   ||.||...:.
Mouse   991 NNNGDLKDDFTTR--HSSVAAGALEFANSWKTS--QECS---DTVTQSFPCD---SNPYCKAWAE 1045

  Fly   587 PA-------LFGECNERLNPENYKAACRMDVCECPSGDCH---CDSFAAYAHECRRLGVQLPDWR 641
            ..       .|.:|:.:::|..|..||..:.|.|.....:   |.:.|.||..|...||.: .||
Mouse  1046 KRCEILRDDTFRDCHSKVDPTTYYDACIEEACSCDMEGKYLGFCTAVAMYAEACNAAGVCV-SWR 1109

  Fly   642 SATNCP 647
            ....||
Mouse  1110 KPNLCP 1115

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	13/76 (17%)
		VWC	256..310	CDD:278520	22/93 (24%)
		VWC	319..376	CDD:214564	11/56 (20%)
		VWD	371..536	CDD:214566	47/191 (25%)
		C8	580..646	CDD:462584	19/75 (25%)
Muc19	NP_997126.2	von Willebrand factor type D domain	47..198
		VWD	52..192	CDD:214566
		TIL	298..353	CDD:410995
		trypsin inhibitor like cysteine rich domain	298..320
		von Willebrand factor type D domain	383..545
		VWD	383..545	CDD:214566
		C8	584..650	CDD:462584	20/104 (19%)
		TIL	654..711	CDD:410995	14/71 (20%)
		TIL	753..813	CDD:410995	12/60 (20%)
		von Willebrand factor type D domain	842..1005		50/217 (23%)
		VWD	842..1003	CDD:214566	50/213 (23%)
		C8	1041..1115	CDD:214843	17/74 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1244..7217
		Approximate repeats	1321..7188
		FhaB	1444..3128	CDD:442443
		FhaB	3237..4921	CDD:442443
		Hia	4704..>5322	CDD:444098
		FhaB	5614..7243	CDD:442443
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	7249..7297
		von Willebrand factor type C domain	7309..7364
		VWC	7309..7364	CDD:214564
		C-terminal cystine knot-like domain	7437..7519
		CT	7437..7519	CDD:214482