Protein Alignment cv-2 and Fras1

DIOPT Version :10

• Sequence 1: NP_524809.2
• Gene: cv-2 / 45280
• FlyBaseID: FBgn0000395
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_780682.3
• Gene: Fras1 / 231470
• MGIID: 2385368
• Length: 4010
• Species: Mus musculus
• Alignment Length: 324
• Identity: 94/324 - (29%)
• Similarity: 122/324 - (37%)
• Gaps: 42/324 - (12%)

  Fly    83 TCFKCECQNGFVNCRDTCPPV---NDCYILDKSN------GTCCRRCK-----GCSFRGMSYESG 133
            :|..|.|....|.|:    ||   |.....:|..      ..||.:|.     .|...|..:|.|
Mouse    44 SCQNCRCHGDIVICK----PVVCKNPRCAFEKGEVLWIAPNQCCPQCAPRTPGSCHHEGKIHEHG 104

  Fly   134 SEWNDPEDPCKTYKCVATVVTETIQKCYS-QCDNNQLQPPRPGECCPTCQG----CKINGQTVAE 193
            :||  ...||....|....|..:.|:|.. .|...:|:....|.|||.|.|    |..:|....:
Mouse   105 TEW--ASAPCTVCSCTHGEVRCSHQQCTPLSCGPQELEFLAEGRCCPICVGTGKPCSYDGHVFQD 167

  Fly   194 GHEVDASIDDRCLVCQCRGTQLTCSKKTCPVLPCPMSKQIKR-PDECCPRCPQNHSFLPVPGKCL 257
            |.:...|   ||..|.||.....|....|..|.|...:.:.| |.:||.:|...        .|.
Mouse   168 GEDWQLS---RCAKCVCRNGLTQCFAAQCQPLFCNQDEIVVRVPGKCCSQCSAR--------SCS 221

  Fly   258 FNKSVYPEKTQFMPDRCTNCTCLNGTSVCQRPTCPILECAP---EFQEPDGCCPRCAVAEVRSEC 319
            ....||....|:..|.||.|.|..|...|.:..||.|.||.   ..:....||..||..: || |
Mouse   222 TAGQVYEHGEQWKEDACTLCMCDQGQVRCHKQVCPPLRCAKGQGRARHHGQCCEECATPD-RS-C 284

  Fly   320 SLDGIVYQNNETWDMGPCRSCRCNGGTIRCAQMRCPAVKCRANEELKQPPGECCQRCVETAGTC 383
            |..|::...:|.|....|..|.|:.|.:.|....|..|.|...|||....|:||..|:...|.|
Mouse   285 SSGGVLRYQDEMWKGSACEFCMCDQGQVTCQTGECAKVACALGEELVHLEGKCCPECISRNGYC 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	17/59 (29%)
		VWC	256..310	CDD:278520	18/56 (32%)
		VWC	319..376	CDD:214564	19/56 (34%)
		VWD	371..536	CDD:214566	5/13 (38%)
		C8	580..646	CDD:462584
Fras1	NP_780682.3	VWC	27..86	CDD:214564	11/45 (24%)
		VWC	94..151	CDD:278520	18/58 (31%)
		VWC	158..215	CDD:278520	17/59 (29%)
		VWC	220..277	CDD:278520	18/56 (32%)
		VWC	284..341	CDD:450195	19/56 (34%)
		VWC	368..415	CDD:450195
		VSP	405..780	CDD:146106
		FU 1	408..459
		FU 2	461..504
		FU 3	506..552
		FU 4	554..598
		FU 5	601..646
		FU 6	648..704
		FU 7	707..752
		FU 8	754..799
		VSP	762..1059	CDD:146106
		FU 9	802..851
		FU 10	853..899
		FU 11	902..947
		FU 12	951..996
		FU 13	998..1041
		FU 14	1045..1088
		FU	1045..1086	CDD:214589
		Cadherin_3	1101..1197	CDD:465048
		CSPG 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	1101..1196
		Cadherin_3	1202..1309	CDD:465048
		CSPG 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	1216..1307
		Cadherin_3	1313..1440	CDD:465048
		CSPG 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	1328..1440
		Cadherin_3	1448..1576	CDD:465048
		CSPG 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	1465..1561
		Cadherin_3	1579..1693	CDD:465048
		CSPG 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	1597..1691
		Cadherin_3	1703..1813	CDD:465048
		CSPG 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	1712..1812
		Cadherin_3	1818..1940	CDD:465048
		CSPG 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	1834..1938
		Cadherin_3	1943..2061	CDD:465048
		CSPG 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	1959..2059
		Cadherin_3	2071..2181	CDD:465048
		CSPG 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	2080..2179
		Cadherin_3	2188..2295	CDD:465048
		CSPG 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	2201..2293
		Cadherin_3	2297..2408	CDD:465048
		CSPG 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	2313..2406
		Cadherin_3	2427..2539	CDD:465048
		CSPG 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	2441..2538
		caca	<2555..>2810	CDD:273296
		Calx-beta	2555..2648	CDD:413355
		caca	<2778..>3045	CDD:273296
		Calx-beta	3037..3131	CDD:413355