DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-2 and Zan

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_035871.2	Gene:	Zan / 22635	MGIID:	106656	Length:	5420	Species:	Mus musculus

Alignment Length:	606	Identity:	165/606 - (27%)
Similarity:	234/606 - (38%)	Gaps:	158/606 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 KGCSFRGMSYESGS--------------------EWNDPEDPCKTYKCVATVVTETIQKCYSQCD 165
            |.|.|.| :|:..|                    .|...||..|.:             ..|:|.
Mouse  1456 KLCGFCG-NYDGDSSNDNLKSDGMMTHDEEELRLSWQVEEDEDKDW-------------VSSRCQ 1506

  Fly   166 NNQLQPPRPGECCPTCQGCKINGQTVAEG--------HEVDASIDDRCL--VCQCRGTQ------ 214
            ..:..|........|..|.|:.||.|...        |...:|..|.|:  :|..:|.|
Mouse  1507 KKKNPPSCDAALGSTMSGPKLCGQLVNPSGPFEACLLHLKASSFLDNCVTDMCSFQGLQQKLCAH 1571

  Fly   215 -----LTCSKKTCPVLPCPMSKQIKRPDECCPR-CPQNHSF----LPVPGKCLFNKSVYP-EKTQ 268
                 .||.....||.|.       |..:.||. ||:|..:    .|.|..|      :| ..||
Mouse  1572 MSAMTATCQDAGYPVKPW-------REPQFCPLVCPKNSRYSLCAKPCPETC------HPISTTQ 1623

  Fly   269 FMPDRCT-NCTC-----LNGTSVCQRPTCPILECAPEFQEPDGCCPRCAVAEVRSECSLDGIVYQ 327
            ...|:|. .|.|     |:|:           ||.|..|  .||            .|..|..::
Mouse  1624 HCSDKCVEGCECDPGFILSGS-----------ECVPSSQ--CGC------------TSFQGRYFK 1663

  Fly   328 NNETWDMGPCRS-CRCNGGTIRCAQMRCPAVKCRANEELKQPPGEC-CQRCVETAGTCTVFGDPH 390
            ..|.|....|:. |.|....    .:.|...||:|.|......|.. |.  .:.|.||.|.||||
Mouse  1664 LQEQWFNPDCKEICTCESHN----HILCKPWKCKAQEACSYKNGVLGCH--AQGAATCMVSGDPH 1722

  Fly   391 FRTFDGKFFSFQGSCKYLLASDCMGKT----FHIRLTNE-GRGTRRASWAKTVTLSLRNLKVNLG 450
            :.||||....|.|:|.|:|...|..|:    |.:..||| ..|....|:.|.|.:.:.:||:::.
Mouse  1723 YLTFDGALHHFMGTCTYVLTQPCWSKSQENNFVVSATNEIHDGNLEVSYVKAVHVQVFDLKISMF 1787

  Fly   451 QRMRVKVNGTRVTLPYFVVAGGQNVTIERLANGGAVMLRSEMGLTLEWNGAGFLQVSVPAKFKKR 515
            :..:|.:|..||.||.:...|  .||| || :|..|:|.:..||.:.::|...::|:||:.:...
Mouse  1788 KGQKVVLNNQRVVLPVWPSQG--RVTI-RL-SGIFVLLYTNFGLQVRYDGRHLVEVTVPSSYTGS 1848

  Fly   516 LCGLCGNFNGSSRDDLTGKDGRSHGDDEVWHFANSWKV------------GGPKSCSRKREFLAA 568
            |||||||:|.:|.||....|.:..|:..:  ...:||:            |.|..|        |
Mouse  1849 LCGLCGNYNNNSMDDNLRVDMKPAGNSLL--LGAAWKILEASDPGCFLVGGKPSRC--------A 1903

  Fly   569 TPTCD---KRKSNFYCHPLSVPALFGECNERLNPENYKAACRMDVCECPSGD----CHCDSFAAY 626
            ....|   .:|.....:||..   |..|:|.:.|:...::|....|| .:||    ||  |..||
Mouse  1904 DSDMDDVWTKKCAILMNPLGP---FSNCHEAVPPQASFSSCVYGQCE-TNGDNLTLCH--SLQAY 1962

  Fly   627 AHECRRLGVQLPDWRSATNCP 647
            |..|.:.| |:..||::|.||
Mouse  1963 ASLCAQAG-QVTTWRNSTFCP 1982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	19/80 (24%)
		VWC	256..310	CDD:278520	16/60 (27%)
		VWC	319..376	CDD:214564	14/58 (24%)
		VWD	371..536	CDD:214566	62/170 (36%)
		C8	580..646	CDD:285899	23/69 (33%)
Zan	NP_035871.2	MAM	47..210	CDD:279023
		MAM	47..208	CDD:99706
		MAM	217..374	CDD:279023
		MAM	217..371	CDD:99706
		MAM	379..542	CDD:279023
		MAM	379..540	CDD:99706
		mucin-like domain	572..1170
		DUF4758	729..899	CDD:292572
		TIL	1215..1264	CDD:280072
		TILa	1266..1319	CDD:289484
		VWD	1326..1478	CDD:278521	6/22 (27%)
		C8	1521..1596	CDD:214843	19/81 (23%)
		TIL	1599..1652	CDD:280072	19/71 (27%)
		TILa	1654..1708	CDD:289484	14/69 (20%)
		VWD	1715..1865	CDD:278521	59/153 (39%)
		C8	1911..1982	CDD:214843	24/77 (31%)
		TIL	1985..2039	CDD:280072
		VWC	2041..2096	CDD:302663
		VWD	2102..2260	CDD:278521
		C8	2310..2380	CDD:285899
		TIL	2384..2442	CDD:280072
		TILa	2444..2498	CDD:289484
		TIL	2504..2562	CDD:280072
		TILa	2564..2618	CDD:289484
		TIL	2624..2682	CDD:280072
		TILa	2684..2738	CDD:289484
		TIL	2744..2802	CDD:280072
		TILa	2804..2858	CDD:289484
		TIL	2864..2922	CDD:280072
		TILa	2924..2978	CDD:289484
		TIL	2984..3042	CDD:280072
		TILa	3044..3098	CDD:289484
		TIL	3104..3162	CDD:280072
		TILa	3164..3218	CDD:289484
		TIL	3224..3282	CDD:280072
		TILa	3284..3338	CDD:289484
		TIL	3344..3399	CDD:280072
		TILa	3401..3455	CDD:289484
		TIL	3461..3519	CDD:280072
		TILa	3521..3575	CDD:289484
		TIL	3581..3639	CDD:280072
		TILa	3641..3695	CDD:289484
		TILa	3761..3815	CDD:289484
		TIL	3821..3879	CDD:280072
		TILa	3881..3931	CDD:289484
		TIL	3937..3995	CDD:280072
		TILa	3997..4051	CDD:289484
		TIL	4073..4131	CDD:280072
		TILa	4133..4184	CDD:289484
		TIL	4193..4251	CDD:280072
		TILa	4253..4300	CDD:289484
		TIL	4308..4366	CDD:280072
		TILa	4368..4422	CDD:289484
		TIL	4428..4486	CDD:280072
		TILa	4488..4542	CDD:289484
		TIL	4548..4606	CDD:280072
		TILa	4608..4662	CDD:289484
		TIL	4668..4726	CDD:280072
		TILa	4728..4782	CDD:289484
		TIL	4788..4846	CDD:280072
		TILa	4848..4902	CDD:289484
		VWD	4909..5062	CDD:278521
		C8	5115..5191	CDD:214843
		TIL	5194..5247	CDD:280072
VWC	5249..5302	CDD:302663
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900