DRSC/TRiP Functional Genomics Resources

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Protein Alignment cv-2 and VWCE

DIOPT Version :10

Sequence 1:NP_524809.2 Gene:cv-2 / 45280 FlyBaseID:FBgn0000395 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_689931.2 Gene:VWCE / 220001 HGNCID:26487 Length:955 Species:Homo sapiens


Alignment Length:469 Identity:120/469 - (25%)
Similarity:181/469 - (38%) Gaps:112/469 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 KFPAQQPRKSLASRRRHTGFRPSTQLLILIAVLL---------------ALLQGRTVDA------ 53
            :.|:..||...:|        ||..:.:|..:|.               :||||..:..      
Human   317 RLPSPTPRLPTSS--------PSAPVWLLSTLLATPVPTASLLGNLRPPSLLQGEVMGTPSSPRG 373

  Fly    54 ------GAGDS----LSGVRQSCSNEGEEVQLKNQPQIFTCFKCECQNGFVNCRDTCPPVNDCYI 108
                  .||.|    |..:.:|.|...|.          .|.:|.|::|.|.|..........:.
Human   374 PESPRLAAGPSPCWHLGAMHESRSRWTEP----------GCSQCWCEDGKVTCEKVRCEAACSHP 428

  Fly   109 LDKSNGTCCRRCKGCSFRGMSYESGSEWNDPEDPCKTYKCVATVVTETIQKCYS-QCDNNQLQPP 172
            :...:|.||..|.||...|:....|..::.|.:.|....|:|..|:     |.| :|.:...|.|
Human   429 IPSRDGGCCPSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVS-----CISPECPSGPCQTP 488

  Fly   173 RPGECCPTC--QGCKINGQTVAEGHEVDASIDDRCLVCQCRGTQLTCSKKTCPVLPCPMSKQIKR 235
            ...:|| ||  ..|..:|:..|:| .|.:...|.|..|.|:..::.||...||.|.||..:....
Human   489 PQTDCC-TCVPVRCYFHGRWYADG-AVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLG 551

  Fly   236 PDECCPRCPQNHSFLPVP--GKCLFNKSV-YPEKTQFMP-DRCTNCTC-LNGTSVCQRPTCPILE 295
            |.:||..|.:     |.|  |..|.:..| :|....:.| |.|..|.| .:|:..|:|..| :..
Human   552 PGQCCFTCQE-----PTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSVSCKRTDC-VDS 610

  Fly   296 CAPEFQEPDGCCPRCAVAEVRSECSLDGIVYQNNETWD--MGPCRSCRCNGGTIRCAQMRCPAVK 358
            |....:.|..|||.|:..     |:..|.::.||||:.  :.||.||.|..|::.|:.:.|| :.
Human   611 CPHPIRIPGQCCPDCSAG-----CTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCP-IT 669

  Fly   359 CRANEELKQPPGECCQRCVETAGTCTVFGDPHFRTFDGKFFSF-------------QGSCK---- 406
            |...   ..|.||||..|.:    |...|.   :..:|:.|:.             :.||:    
Human   670 CTYP---FHPDGECCPVCRD----CNYEGR---KVANGQVFTLDDEPCTRCTCQLGEVSCEKVPC 724

  Fly   407 -------YLLASDC 413
                   .||..||
Human   725 QRACADPALLPGDC 738

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cv-2NP_524809.2 VWC 184..243 CDD:214564 19/58 (33%)
VWC 256..310 CDD:278520 17/56 (30%)
VWC 319..376 CDD:214564 21/58 (36%)
VWD 371..536 CDD:214566 14/67 (21%)
C8 580..646 CDD:462584
VWCENP_689931.2 EGF_CA 142..180 CDD:214542
FXa_inhibition 190..218 CDD:464251
EGF_CA 220..262 CDD:214542
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 292..329 3/11 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 360..380 3/19 (16%)
VWC 386..440 CDD:450195 13/63 (21%)
VWC 443..>488 CDD:450195 12/49 (24%)
VWC 501..559 CDD:450195 19/58 (33%)
VWC 572..625 CDD:214564 16/53 (30%)
VWC 629..684 CDD:450195 21/58 (36%)
VWC 687..742 CDD:450195 10/55 (18%)
PHA03247 <726..944 CDD:223021 4/13 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 812..889
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 903..955
Blue background indicates that the domain is not in the aligned region.

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