DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cv-2 and irg-5

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001366887.1	Gene:	irg-5 / 185307	WormBaseID:	WBGene00009429	Length:	343	Species:	Caenorhabditis elegans

Alignment Length:	205	Identity:	41/205 - (20%)
Similarity:	59/205 - (28%)	Gaps:	76/205 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 TIRCAQMRCPAVKCRANEELKQ--PPGECCQRCVETAGTCTVFGDPHFRTFDGKFFSFQGSCKYL 408
            |...||..||......|..:..  |||......|....|||              |.|.
Worm    14 TFVAAQFSCPLNTISKNNGMSGSIPPGAASMVQVPAGSTCT--------------FKFD------ 58

  Fly   409 LASDCMGKTFHIRLTNEGRGTRRASWAKTVTLSLRNLKVNLGQRMRVKVNGTRVTLPYFVV---- 469
                 :.|.|.:::..    |.....:|..::...:..:......:::. ..|.||||.||
Worm    59 -----IPKGFALKIET----TADYDISKRDSIKFDDFYITSPAEKKIEY-AVRKTLPYNVVSKSG 113

  Fly   470 ---------------------AGGQ--NVTIE-------RLANGGAVMLR---SEMGL------- 494
                                 |.|.  |.|:|       |.||...|.|:   .|.|.
Worm   114 SLKFFATYTYVDISNYQQVIKATGTFFNTTLEANKFTTVRAANNDQVALKYGSRETGFHDETMYQ 178

  Fly   495 TLEWNGAGFL 504
            |..::|..|:
Worm   179 TFVFDGNDFM 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564
		VWC	256..310	CDD:278520
		VWC	319..376	CDD:214564	9/31 (29%)
		VWD	371..536	CDD:214566	32/178 (18%)
		C8	580..646	CDD:285899
irg-5	NP_001366887.1	CUB_2	17..127	CDD:280554	25/139 (18%)
irg-5	NP_001366887.1	BBS2_N	<209..278	CDD:405471
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900