DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cv-2 and COCH

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001334649.1	Gene:	COCH / 1690	HGNCID:	2180	Length:	615	Species:	Homo sapiens

Alignment Length:	270	Identity:	55/270 - (20%)
Similarity:	85/270 - (31%)	Gaps:	62/270 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   500 GAGFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTGKDG-RSHGDDEVWHFA-----NSWKVGGPKS 558
            |.|...:.:|........|..|::..|.|.......| :...|...|..|     ...||..|:.
Human    10 GLGVCLLLLPGPAGSEGAGEWGSWGASRRSQGLSTSGYKRDSDPAPWASALPPEEEGAKVEPPRG 74

  Fly   559 CSRKREFLAATPTCDKRKSNFYCH-PLSVPALFGECNER-LNPENYKAACRMDVCECPSGDCHCD 621
            ..      |.||..|......:.| |:::     .|..| |:....||    ||. ||.| |..:
Human    75 AP------ALTPAADLLLLTCFSHAPIAI-----TCFTRGLDIRKEKA----DVL-CPGG-CPLE 122

  Fly   622 SFAAYAH-----------ECRRLGV-----------QLPDWRSATNCPAGWRRNATLSSFKGNQF 664
            .|:.|.:           .....||           .||...:.::..|...::..||.:..
Human   123 EFSVYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSA--- 184

  Fly   665 YGDPSFSRMKGRRQKNHQLRLQLQQEQQQRSKQGQKGRHKPGGHNQ--------LDRQGHNGLDK 721
                ||:..||:..........:........|:.:|...|..|:..        :|...:.|..:
Human   185 ----SFTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRR 245

  Fly   722 DQLQKEFILK 731
            ..|||.|:.|
Human   246 FNLQKNFVGK 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564
		VWC	256..310	CDD:278520
		VWC	319..376	CDD:214564
		VWD	371..536	CDD:214566	7/35 (20%)
		C8	580..646	CDD:285899	19/89 (21%)
COCH	NP_001334649.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900