DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cv-2 and BMPER

DIOPT Version :9

Sequence 1:NP_524809.2 Gene:cv-2 / 45280 FlyBaseID:FBgn0000395 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_001352237.1 Gene:BMPER / 168667 HGNCID:24154 Length:685 Species:Homo sapiens


Alignment Length:668 Identity:229/668 - (34%)
Similarity:314/668 - (47%) Gaps:88/668 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 SLASR--RRHTGFRPSTQLLILIAVLLALLQGRTVDAGAGDSLSGVRQSCSNEGEEVQ---LKNQ 78
            :||.|  ||..|        |...|||.|.......:.|...|:|....|.||||.:|   :.:.
Human     9 ALAERYCRRSPG--------ITCCVLLLLNCSGVPMSLASSFLTGSVAKCENEGEVLQIPFITDN 65

  Fly    79 PQIFTCFKCECQNGFVNC-RDTCPPVN-DCYILDKSNGTCCRRCKGCSFRGMSYESGSEWNDPED 141
            |    |..|.|.|..|.| |:.||.:: ||.:..|..|.||.:||||::.|.:|.|..:|..|.:
Human    66 P----CIMCVCLNKEVTCKREKCPVLSRDCALAIKQRGACCEQCKGCTYEGNTYNSSFKWQSPAE 126

  Fly   142 PCKTYKCVATVVTETIQKCYSQCDNNQLQPPRPGECCPTCQGCKINGQTVAEGHEVDASIDDRCL 206
            ||...:|...||||:..:|...| .|.|:  ..|.|||||.||...|....||.|.... ..:|.
Human   127 PCVLRQCQEGVVTESGVRCVVHC-KNPLE--HLGMCCPTCPGCVFEGVQYQEGEEFQPE-GSKCT 187

  Fly   207 VCQCRGTQLTCSKKTCPVLPCPMSKQIKRPDECCPRCPQNHSFLPVP-GKCLFNKSVYPEKTQFM 270
            .|.|.|.:..|.::.||:|.||.......|.:|||:|........:| |.|||...||...:.|:
Human   188 KCSCTGGRTQCVREVCPILSCPQHLSHIPPGQCCPKCLGQRKVFDLPFGSCLFRSDVYDNGSSFL 252

  Fly   271 PDRCTNCTCLNGTSVCQRPTCPILECAPEFQEPDGCCPRCAV---AEVRSECSLDGIVYQNNETW 332
            .|.||.|||.:.|.||:|.......|.   |..:|||..|.:   .|....|.....::|:.|.|
Human   253 YDNCTACTCRDSTVVCKRKCSHPGGCD---QGQEGCCEECLLRVPPEDIKVCKFGNKIFQDGEMW 314

  Fly   333 DMGPCRSCRCNGGTIRCAQMRC-PAVKCRANEELKQPPGE------CCQRCVETAGTCTVFGDPH 390
            ....|..|.|..|...|...:| |...|        |.|:      ||..|.|..|.||||||||
Human   315 SSINCTICACVKGRTECRNKQCIPISSC--------PQGKILNRKGCCPICTEKPGVCTVFGDPH 371

  Fly   391 FRTFDGKFFSFQGSCKYLLASDCM--GKTFHIRLTNEGRGTRRASWAKTVTLSLRNLKVNLGQRM 453
            :.||||:.|:|||:|:|:|..||.  ...|.:.:.|:.|.||..||.|:|.|.|...:|:|.|.:
Human   372 YNTFDGRTFNFQGTCQYVLTKDCSSPASPFQVLVKNDARRTRSFSWTKSVELVLGESRVSLQQHL 436

  Fly   454 RVKVNGTRVTL----PYFVVAGGQNVTIERLANGGAVMLRSEMGLTLEWNGAGFLQVSVPAKFKK 514
            .|:.||:|:.|    |:|.:.          .:|..:.:.::.||.:.|:|..|::|......|.
Human   437 TVRWNGSRIALPCRAPHFHID----------LDGYLLKVTTKAGLEISWDGDSFVEVMAAPHLKG 491

  Fly   515 RLCGLCGNFNGSSRDDLTGKDGRSHGDDEVWHFANSWKVGGPKSCSRKRE-------------FL 566
            :|||||||:||..||||.|.||....|  |..||.||:|...:.|:|.:.             .|
Human   492 KLCGLCGNYNGHKRDDLIGGDGNFKFD--VDDFAESWRVESNEFCNRPQRKPVPELCQGTVKVKL 554

  Fly   567 AATPTCDKRKSNFYCHPLSVPALFGECNERLNPENYKAACRMDVCECP-SGDCHCDSFAAYAHEC 630
            .|...|.|.||          ..|..|:..::...:..:|..|:|||| ..:|:|:||.||...|
Human   555 RAHRECQKLKS----------WEFQTCHSTVDYATFYRSCVTDMCECPVHKNCYCESFLAYTRAC 609

  Fly   631 RRLGVQLPDWRSATNCPA 648
            :|.|::: .|....||.|
Human   610 QREGIKV-HWEPQQNCAA 626

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cv-2NP_524809.2 VWC 184..243 CDD:214564 19/58 (33%)
VWC 256..310 CDD:278520 21/53 (40%)
VWC 319..376 CDD:214564 16/63 (25%)
VWD 371..536 CDD:214566 69/176 (39%)
C8 580..646 CDD:285899 18/66 (27%)
BMPERNP_001352237.1 VWC 166..224 CDD:278520 19/58 (33%)
VWC 301..357 CDD:327433 16/63 (25%)
VWD 364..508 CDD:306577 61/153 (40%)
C8 560..624 CDD:312319 22/74 (30%)
TIL 629..682 CDD:307783
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 98 1.000 Domainoid score I7208
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H12494
Inparanoid 1 1.050 381 1.000 Inparanoid score I2064
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47479
OrthoDB 1 1.010 - - D1104860at2759
OrthoFinder 1 1.000 - - FOG0006882
OrthoInspector 1 1.000 - - oto91150
orthoMCL 1 0.900 - - OOG6_106931
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5817
SonicParanoid 1 1.000 - - X5778
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1413.810

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