Protein Alignment cv-2 and Vwf

DIOPT Version :10

• Sequence 1: NP_524809.2
• Gene: cv-2 / 45280
• FlyBaseID: FBgn0000395
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_446341.1
• Gene: Vwf / 116669
• RGDID: 621759
• Length: 2812
• Species: Rattus norvegicus
• Alignment Length: 671
• Identity: 165/671 - (24%)
• Similarity: 232/671 - (34%)
• Gaps: 235/671 - (35%)

  Fly    65 SCSNEGEEVQLKNQPQIFTCFKCECQNGFVNCRDTCPPVNDCYILDKSNGTCCRRCKGCSFRGMS 129
            :|:.:|..:..: :|. |....|.....::.|.::|            |.||         |.:|
  Rat   632 ACARKGVHIGWR-EPD-FCALSCPQGQVYLQCGNSC------------NMTC---------RSLS 673

  Fly   130 YESGSEWNDPEDPCKTYKCVATVVTETIQKCYSQCDNNQLQPPRPGECCPTCQ-GCKINGQTVAE 193
            .        |::.|... |        ::.|:  |.....|..| |:|.|..| .|..:|:...
  Rat   674 L--------PDEECSEV-C--------LEGCF--CPPGLYQDER-GDCVPKAQCPCYHDGELFQ- 717

  Fly   194 GHEVDASI-DDRCLVCQCRGTQLTC-----SKKTCP--VLPCPMSKQIKRPDECCPR-----CPQ 245
                .|.| .|...:|.|....:.|     |....|  ||..|:|.:.||...|.|.     ||.
  Rat   718 ----PADIFSDHHTMCYCEDGFMHCTTSGASGSLLPNIVLSSPLSHRSKRSLSCRPPMVKLVCPA 778

  Fly   246 NHSFLPVPGKCLFNKSVYPEKTQFMPDRCTNCTCLNGTSVCQRPTCPILECAPEFQEPD------ 304
            ::                                         |....||||...|..|
  Rat   779 DN-----------------------------------------PRAQGLECAKTCQNYDLECMSL 802

  Fly   305 ----GC-CP--------RCAVAEVRSECSLDGIVYQNNETWDMGPCRSCRCNGGTIRCAQMRCPA 356
                || ||        ||...| |..|...|..|...:|..:| |.:|.|......|....|.|
  Rat   803 GCVSGCLCPPGMVRHENRCVALE-RCPCFHQGEAYSPGDTVKIG-CNTCVCRDRRWNCTTHVCDA 865

  Fly   357 VKCRANEELKQPPGECCQRCVETAGTCTVFGDPHFRTFDGKFFSFQGSCKYLLASD-CMGK--TF 418
                                     ||:..|..|:.||||..:.|.|.|:|:|..| |.|.  ||
  Rat   866 -------------------------TCSALGMAHYLTFDGLKYLFPGECQYVLVQDYCGGSSGTF 905

  Fly   419 HIRLTNEGRGTRRASWAKTVT-------LSLRNLKVNLGQRMRVKVNGTRVTLPYFVVAGGQNVT 476
            .|.:.|||.........|.||       :.|.|.:||:.:.::.:.:
  Rat   906 RILVGNEGCTYPSVKCKKRVTILVDGGEIELFNGEVNVKRPLKDESH------------------ 952

  Fly   477 IERLANGGAVMLRSEMGLTLEWNGAGFLQVSVPAK--FKKRLCGLCGNFNGSSRDDLTGKDGRSH 539
            .|.:.:|..|:|....||::.|:..  |.:||..|  :::.:|||||||:|...:|.|...  ..
  Rat   953 FEMVESGQYVILLLGQGLSVVWDHR--LSISVVLKYTYQEHVCGLCGNFDGIQNNDFTSSS--LQ 1013

  Fly   540 GDDEVWHFANSWKVGGPKSCSRKREFLAATPTC-DKRK-----SNFYCH-------------PLS 585
            .:::...|.|||||               :|.| |.||     |...||             .:.
  Rat  1014 VEEDPIDFGNSWKV---------------SPQCADTRKLSLDVSLAACHNNIMKQTMVDSSCRIL 1063

  Fly   586 VPALFGECNERLNPENYKAACRMDVCECPS-GD--CHCDSFAAYAHECRRLGVQLPDWRSATNCP 647
            ...:|..||..::||.|...|..|.|.|.| ||  |.||:.|||||.|.:.| |:..||..|.||
  Rat  1064 TSDIFQGCNRLVDPEPYLDICIYDTCSCESIGDCSCFCDTIAAYAHVCAQHG-QVVAWRKPTLCP 1127

  Fly   648 AG--------------WRRNA 654
            ..              ||.|:
  Rat  1128 QSCEERNVRENSYECEWRYNS 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	18/71 (25%)
		VWC	256..310	CDD:278520	11/72 (15%)
		VWC	319..376	CDD:214564	11/56 (20%)
		VWD	371..536	CDD:214566	50/176 (28%)
		C8	580..646	CDD:462584	29/81 (36%)
Vwf	NP_446341.1	VWD	35..179	CDD:459671
		C8	218..292	CDD:214843
		TIL	295..348	CDD:410995
		VWD	388..541	CDD:459671
		C8	579..649	CDD:214843	4/18 (22%)
		TIL	652..707	CDD:410995	18/95 (19%)
		TIL	<788..827	CDD:410995	11/39 (28%)
		VWD	856..1011	CDD:214566	53/199 (27%)
		C8	1053..1127	CDD:214843	27/74 (36%)
		TIL	1146..1196	CDD:410995	1/3 (33%)
		VWA_N2	1198..1276	CDD:465038
		VWA	1277..1449	CDD:214621
		VWA	1498..1658	CDD:459670
		VWA	1691..1862	CDD:459670
		VWD	1950..2102	CDD:459671
		C8	2138..2199	CDD:462584
		TIL	2203..2254	CDD:410995
		VWC	2257..2321	CDD:214564
		VWC	2431..2494	CDD:214564
		VWC	2581..2643	CDD:450195
		CT	2726..2807	CDD:214482