DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-2 and kcp

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_002931908.3	Gene:	kcp / 100491140	XenbaseID:	XB-GENE-486713	Length:	2327	Species:	Xenopus tropicalis

Alignment Length:	671	Identity:	220/671 - (32%)
Similarity:	297/671 - (44%)	Gaps:	115/671 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 CSNEGEEVQLKNQ--PQIFTCFKCECQNGFVNCR-DTCPPVNDCYILDKSNGTCCRRCKGCSFRG 127
            |..:|:|......  |....|.||.|.||.|.|. ..|||: .|.......|.||.||:||.:.|
Frog  1616 CRYQGKEYSEDAHWVPVTDLCLKCTCTNGNVVCEPPQCPPL-PCTQQVTDPGACCPRCRGCIYNG 1679

  Fly   128 MSYESGSEWNDPEDPCKTYKCVATVVTETIQKCYSQCDNNQLQPPRPGECCPTCQGC----KI-- 186
            ..|:..|.|....|||.:..||..|.|.:..:|.:.|.|   |...||||||.|..|    |:
Frog  1680 REYKDNSNWLSSSDPCMSCMCVDGVTTCSKLQCINSCTN---QITVPGECCPVCADCISSNKVYL 1741

  Fly   187 ---------------------NGQ-------------------------------TVAE------ 193
                                 |||                               |.|:
Frog  1742 PGESYHPSKDPCEICTCERLPNGQQYRHCTKKQCPSLLDCPRNYILPPAEGQCCSTCAQALSNCT 1806

  Fly   194 ----GHEVDASIDDRCLVCQCRGTQLTCSKKTCPVLPCPMSKQIKRPDECCPRCPQNHSFLPVPG 254
                |:|:.|: ||.|..|.|:.....|..:.||||.||.::|......|||.|.:  ..:.:.|
Frog  1807 DTLVGNEIQAT-DDPCYTCHCKDLTWVCVHQPCPVLSCPRAEQFTHSGSCCPVCKE--CVVEIEG 1868

  Fly   255 KCLFNKSVYPEKTQFMPDRCTNCTCLNGTSVCQRPTCPILECAP---EFQEPDGCCPRCAVAEVR 316
            :.:.:...:.::    .|.|..|||..|...||...|..::|..   ..:.|..||..|....|
Frog  1869 RRVPDGETWTDR----QDPCVTCTCTLGHVECQIEECQPVQCQEGEMRVRRPGACCHECQAPAV- 1928

  Fly   317 SECSLDGIVYQNNETWDMGPCRSCRCNGGTIRCAQMRCPAVKCRANEELKQPPGECCQRCVETAG 381
             .|...|..:.:||.|.:..|.:|.|..|.:.|...|||.|.|.|.|.....||.||..|:....
Frog  1929 -SCWYQGQRFLSNEHWQVDECTACTCVSGEVHCHSERCPQVSCTAEETPALIPGMCCPHCIPRPA 1992

  Fly   382 TCTVFGDPHFRTFDGKFFSFQGSCKYLLASDCMGKTFHIRLTNEGRGTRRASWAKTVTLSLRNLK 446
            ||..|||||:||||||.:.|||||.|:|:.||.|..|.|.:||:.||.|..||.|.||:.:.:..
Frog  1993 TCIAFGDPHYRTFDGKMYHFQGSCTYVLSEDCEGGDFSIHVTNDDRGLRGVSWTKEVTVLIGDAV 2057

  Fly   447 VNLGQRMRVKVNGTRVTLPYFVVAGGQNVTIERLANGGAVMLRSEMGLTLEWNGAGFLQVSVPAK 511
            |.|.|...|.|:...|.||:.   ....:.|||..|  .::|.|.:|:.::|||...|:||||..
Frog  2058 VQLLQDWVVMVDYQTVELPFL---KEPYIYIERKTN--TILLNSNIGVKVQWNGRSHLEVSVPGT 2117

  Fly   512 FKKRLCGLCGNFNGSSRDDLTGKDGRSHGDDEVWHFANSWKV----GGPKSC--------SRKRE 564
            ::..|||||||||...:|||..:.|:....:..  |.|||:|    ....||        .::..
Frog  2118 YRDHLCGLCGNFNNYPQDDLRDRRGQILLSEAA--FGNSWRVQSSNDSSSSCWDGQDVDPCKQAG 2180

  Fly   565 FLAATPTCDKRKSNFYCHPLSVPALFGECNERLNPENYKAACRMDVCECPSGD-CHCDSFAAYAH 628
            :.|      ::::|..|..|. ..:|..|:..:.||.:.|:|..|:|.|.:|| |.||...|||.
Frog  2181 YRA------RKEANGRCKLLK-STVFEPCHRVVPPEMFFASCVYDLCACGAGDECLCDVLEAYAS 2238

  Fly   629 ECRRLGVQLPDWRSATNCPAG 649
            |||..||.| .|||...|..|
Frog  2239 ECREAGVIL-QWRSPALCAVG 2258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	26/126 (21%)
		VWC	256..310	CDD:278520	13/56 (23%)
		VWC	319..376	CDD:214564	21/56 (38%)
		VWD	371..536	CDD:214566	73/164 (45%)
		C8	580..646	CDD:285899	28/66 (42%)
kcp	XP_002931908.3	LamG	39..>186	CDD:419873
		VWC	383..437	CDD:327433
		VWC	445..492	CDD:327433
		VWC	496..552	CDD:327433
		VWC	612..668	CDD:327433
		VWC	671..727	CDD:327433
		VWC	730..785	CDD:327433
		VWC	788..846	CDD:327433
		VWC	849..906	CDD:327433
		VWC	968..1024	CDD:327433
		VWC	<1103..1141	CDD:327433
		VWC	1262..1318	CDD:327433
		Amnionless	<1461..>1497	CDD:405512
		VWC	1498..1554	CDD:327433
		VWC	1557..1613	CDD:327433
		VWC	1616..1672	CDD:327433	19/56 (34%)
		VWC	1733..1798	CDD:327433	5/64 (8%)
		VWC	1930..1987	CDD:327433	21/56 (38%)
		VWD	1985..2142	CDD:214566	71/161 (44%)
		C8	2190..2255	CDD:400886	28/66 (42%)
		TIL	2266..2319	CDD:410995
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4720
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104860at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46698
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020