DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-2 and LOC100485197

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_031756619.1	Gene:	LOC100485197 / 100485197	-ID:	-	Length:	2165	Species:	Xenopus tropicalis

Alignment Length:	760	Identity:	166/760 - (21%)
Similarity:	267/760 - (35%)	Gaps:	250/760 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FPAQQPRKSLASRRRHTGFRPSTQLLILIAVLLALLQGRTVDAGAGDSLSGVRQSCSN----EGE 71
            |...||.:|....:...|.:....||.|:.:.:::      |....::..|:   |.|    ||:
Frog   492 FSVIQPTESNIFVKTKFGLQMQIYLLPLMQLYISM------DNSDKNTFEGL---CGNFNYKEGD 547

  Fly    72 EVQLKNQPQIFTCFKCE--CQNGFVN-------CRDTCPPVNDCYILDKSNGTCCRRCKGCSFRG 127
            :        ..|....|  ..:.|.|       |:|:...:.|                .|||..
Frog   548 D--------FITSAGIEESTASAFANTWKIQSTCQDSVEVLID----------------PCSFSM 588

  Fly   128 MSYESGSEW----NDPE----------DPCKTYK--------------CVATVVTETIQKCYSQ- 163
            .:.....:|    .|.|          ||.:.||              |:...::...:.|.::
Frog   589 ETKIYAEKWCSLLRDSESPFWKCHFAVDPSEYYKRCEYDTCSCSHSEACMCATLSSYARACAAKG 653

  Fly   164 ----------CDNNQLQPPRPGECCPTCQGCKINGQTVAEGHEVDASIDDRCLVCQ--CRGTQL- 215
                      ||..          .|:|...:|....:.              .||  ||...|
Frog   654 IILWDWKKGICDKE----------IPSCPASQIYLYNIT--------------TCQPTCRSLALE 694

  Fly   216 --TCSKKTCPV--LPCPMSKQIKRPDECCPRCPQNHSFLPVPGKC-LFNKSVY--PEKTQF-MPD 272
              .|..:..||  ..||....:...|.|.|:           .:| .:::.:|  |.:..: |.:
Frog   695 EKECDSEFTPVDGCGCPDGMYLNEKDSCVPK-----------SQCSCYHQGMYLRPNEVFYRMDE 748

  Fly   273 RCT------NC------TCLNG-----------TSVCQRPTCPILECAPEFQEPDGCCPRCAVAE 314
            ||:      ||      ||.||           :.:.:..:|..|...|   ...||...|...:
Frog   749 RCSCHEGKLNCDSFINDTCSNGKVFLDCKKEKRSHMSRHRSCRTLNIGP---VGTGCISGCVCPD 810

  Fly   315 -----------VRSECSLDGIVYQNNETWDMG-----PCRSCRCNGGTIRCAQMRCPAVKCRANE 363
                       |.|.|...    .||:.:..|     .|:||.|..|...|.|..|
Frog   811 GLLDDGHGGCVVESSCPCS----YNNKVFAHGSRLIEECKSCTCESGLWSCIQTPC--------- 862

  Fly   364 ELKQPPGECCQRCVETAGTCTVFGDPHFRTFDGKFFSFQGSCKYLLASDCMGK-----TFHIRLT 423
                            .||||::|..|:.|||.||:.|.|||::::|.|..|.     ||.|...
Frog   863 ----------------YGTCTIYGSGHYITFDKKFYDFDGSCEFVVAQDYCGDSASNGTFRIITE 911

  Fly   424 NEGRGTRRASWAKTVTLSLRNLKVNL-GQRMRVKVNGTRVTLPYFVVAGGQNVTIERLANGGAVM 487
            |...||...:.:|::.:.|.|.::.| ...|..|.......:.|.|...|..:.|
Frog   912 NIPCGTTGVTCSKSIKIYLGNTELKLTNSHMEKKFGEFETEVGYKVREVGLYLAI---------- 966

  Fly   488 LRSEMGLTLEWNGAGFLQVSVPAKFKKRLCGLCGNFNGSSRDD-LTGKDGRSHGDDEVWHFANSW 551
             |:...::|.|:....|.:.:|:.:|.::||||||::.::.:| ||.:..::   .....|.|||
Frog   967 -RTSSDISLIWDKKTSLLIRLPSSYKGKVCGLCGNYDDNANNDFLTSQSIQA---SNAMPFGNSW 1027

  Fly   552 KVGG--------PKSC---SRKREFLAATPTCDKRKSNFYCHPLSVPALFGECNERLNPENYKAA 605
            |...        |:.|   ..:|.:  |...||...:|          :|..|:.:::|:.:..|
Frog  1028 KRSNDCPDANSIPQPCLAAPHRRSW--AEKKCDIITNN----------VFARCHSKVDPKPFYDA 1080

  Fly   606 CRMDVCECPSG---DCHCDSFAAYAHECRRLGVQLPDWRSATNCP 647
            |..|||.|.:|   :|.|.:.||||..|.:..|.: .||:...||
Frog  1081 CVNDVCSCDTGGDCECFCTAVAAYAQLCAKADVCI-HWRTPEICP 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	14/65 (22%)
		VWC	256..310	CDD:278520	17/80 (21%)
		VWC	319..376	CDD:214564	12/61 (20%)
		VWD	371..536	CDD:214566	49/171 (29%)
		C8	580..646	CDD:285899	20/68 (29%)
LOC100485197	XP_031756619.1	VWD	52..203	CDD:214566
		C8	253..312	CDD:400886
		TIL	316..372	CDD:410995
		VWD	401..554	CDD:214566	15/78 (19%)
		C8	593..659	CDD:214843	9/65 (14%)
		TIL	671..728	CDD:410995	15/81 (19%)
		VWC	828..>874	CDD:327433	16/74 (22%)
		VWD	855..1013	CDD:214566	52/193 (27%)
		C8	1052..1124	CDD:214843	24/84 (29%)
		VWD	1464..1631	CDD:214566
		C8	1669..1731	CDD:400886
		CT	2038..2121	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910