Protein Alignment cv-2 and muc5.1

DIOPT Version :10

• Sequence 1: NP_524809.2
• Gene: cv-2 / 45280
• FlyBaseID: FBgn0000395
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: XP_021326297.2
• Gene: muc5.1 / 100148804
• ZFINID: ZDB-GENE-120822-1
• Length: 5227
• Species: Danio rerio
• Alignment Length: 738
• Identity: 174/738 - (23%)
• Similarity: 255/738 - (34%)
• Gaps: 234/738 - (31%)

  Fly    29 FRPSTQLLI-----------LIAVLLALLQGRTVDAGAGDSLSGVRQSCSNEGEEVQLKNQPQIF 82
            |:||:..:|           |..|:...:...|.:.|   .::|:   |.|. .:||..:
Zfish   513 FQPSSSFIIVDLTSVRLEIQLAPVMQLYIVASTEEKG---KMTGL---CGNY-NDVQTDD----- 565

  Fly    83 TCFKCE------CQNGFVN-CRDTCPPV-----NDCYI--------------LDKSNGTC--CRR 119
              ||.|      ....||| .:..||.:     |.|.:              |...|||.  |..
Zfish   566 --FKTESGIIEGTPTSFVNFWKQNCPDLEITFDNPCSLNMDTEKLAKDWCSRLTNPNGTFSECHS 628

  Fly   120 --CKGCSFRGMSYESGSEWNDPEDPCK---TYKCVATVVTE----------------TIQKCYSQ 163
              |....::...|          |.||   ..||:...|:.                ..:.|.|:
Zfish   629 EICPEMYYQRCVY----------DTCKCSDIRKCICAAVSTYAHACAARGIILHDWMDTEPCESE 683

  Fly   164 CDNNQLQPPRPGECCPTCQGCKINGQTVAEGHEVDASIDDRCLVCQCRGTQLTCSKKTCPVLPCP 228
            |..|.........|..||:  .::||                        :.||.....||..|.
Zfish   684 CPENMKHSYEVTSCGSTCR--SLSGQ------------------------ENTCQGSFTPVHGCV 722

  Fly   229 MSK--QIKRPDEC--CPRCPQNHSFLPVPGKCLFNKSVYPEKTQFMPDRCTNCTCLNGT------ 283
            .|:  .:....:|  ...||           |.:...|.....:|..:. ..|||.||.
Zfish   723 CSEGTYLNEEGKCVHAGMCP-----------CYYGNQVIQPSAEFNKEG-AKCTCNNGKLDCSSH 775

  Fly   284 -------------------SVCQRPTCPILECAPEFQEPDGC----------CPRCAVAEVRSEC 319
                               :.||| ||       :.|:|:.|          ||...:|:.:..|
Zfish   776 EDCVAPMTFFKCSHPGEKGTECQR-TC-------DKQDPNNCVSTGCVSGCMCPEGLLADGKGGC 832

  Fly   320 SL--------DGIVYQNNETWDMGPCRSCRCNGGTIRCAQMRCPAVKCRANEELKQPPGECCQRC 376
            .:        :|:.....:.... .|.:|.|..|...|.|..|
Zfish   833 VMRENCPCTHNGVTSSPGDQVQQ-DCNTCTCTNGMWICTQKAC---------------------- 874

  Fly   377 VETAGTCTVFGDPHFRTFDGKFFSFQGSCKYLLASD-CMGK---TFHIRLTNEGRGTRRASWAKT 437
               .||||::|:.|||||||..:||.|.|::.||.| |.|.   :|.:...|....|..:..:|:
Zfish   875 ---YGTCTIYGEGHFRTFDGNRYSFHGDCEHTLAHDYCDGNPSPSFRLVTENIPCATANSICSKS 936

  Fly   438 VTLSLRNLKVNLGQRMRVKV---NGTRVTLPYFVVAGGQNVTIERLANGGAVMLRSEMGLTLEWN 499
            :.|.....::.|.:...|||   |||.  ..|.:..||..|.||           .|..|.|.|:
Zfish   937 INLFFGRYEMILSEDDGVKVVEGNGTE--YKYQINYGGIYVVIE-----------IEGLLNLIWD 988

  Fly   500 GAGFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTGKDGRSHGDDEVWHFANSWKVGGPKSCSRKRE 564
            ....:.:.:..|.|..:|||||||:|::.:|....:|....|.|  .|.|||||  ..:|.....
Zfish   989 EKTSVMIQLHPKLKGNVCGLCGNFDGNANNDFMKHNGEVVTDPE--EFGNSWKV--DSNCPDVTN 1049

  Fly   565 FLAATPTCDKRKS--NFYCHPLSVPALFGECNERLNPENYKAACRMDVCECPSG---DCHCDSFA 624
            .:........|.|  ...|..::.| :|.:|:..::...|..||..|.|.|.||   ||.|.:..
Zfish  1050 VMHPCEAHPHRNSWAIKQCRIITSP-VFTDCHSLVDSGPYYDACVRDTCACDSGGDCDCLCTAVG 1113

  Fly   625 AYAHECRRLGVQLPDWRSATNCP 647
            |||.|||:.|..:. ||:...||
Zfish  1114 AYAAECRKRGACVA-WRTPHFCP 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	9/62 (15%)
		VWC	256..310	CDD:278520	18/88 (20%)
		VWC	319..376	CDD:214564	9/64 (14%)
		VWD	371..536	CDD:214566	54/171 (32%)
		C8	580..646	CDD:462584	24/68 (35%)
muc5.1	XP_021326297.2	None