DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cv-2 and zanl

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001352287.1	Gene:	zanl / 100147904	ZFINID:	ZDB-GENE-060131-2	Length:	4516	Species:	Danio rerio

Alignment Length:	778	Identity:	192/778 - (24%)
Similarity:	283/778 - (36%)	Gaps:	222/778 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 QGRTVDAG----AGDSLSGVRQSCS------NEGEEVQLKNQPQIFTC-FKCECQNGFVNCRDT- 99
            :|...|.|    ||..:......|:      ..|||...|:      | ..|:|...||.|...
Zfish  2757 EGCVCDPGYILSAGQCVKENTCGCTFNDHYYKPGEEFYTKD------CDLLCKCDPPFVTCNAAD 2815

  Fly   100 CPPVNDCYILD-----------------------------KSNGTC----CRRCKGCSFRGMSYE 131
            |||:..|.:.|                             ...|||    .|.||..:....|.|
Zfish  2816 CPPMEQCGVQDGITGCYPQGSQDCVVSGDPHYNTFDGKFYSYMGTCTYTLARTCKNNTGPWFSIE 2880

  Fly   132 SGSEWNDPEDPCKTYKCVATV--VTETIQKCYSQCDN-----NQLQPPRPGECCP---------- 179
            ..:|...........|...||  :|.|:.|      |     |.|:...|....|
Zfish  2881 GKNEERGASGVSYLRKLYVTVDGITVTMMK------NKRTLVNGLRVTLPHSPSPLISLSLAGQY 2939

  Fly   180 ----TCQGCKI--NGQTVAEGHEVDASIDDRCLVC------------QCRGTQLTCSK------- 219
                |..|.|:  :|...|:.....:..|..|.:|            :..|||:..||
Zfish  2940 VILTTPFGLKVQWDGNHYAKISVPSSYYDQMCGLCGDYDGNPNNDFTKPDGTQVDSSKLFGDSWQ 3004

  Fly   220 ------KTC-----PVLPCP--MSKQIKRPDECCPRCPQNHSF---------LPVPGKCLFNKSV 262
                  .||     |..||.  :..::.:|:.|......|..|         ||....|:|:...
Zfish  3005 TKEDEDATCKPDPGPQPPCDPVLEGEVSKPENCGKITDTNGPFRDCIKVVNPLPFFQSCVFDMCH 3069

  Fly   263 YPEKTQFMPDRCTNCT--CLN-GTSVCQ--RPT-CPILECAPE----------------FQEPDG 305
            |....|.:.|:....|  ||: |..|.|  .|. ||:: |.|.                ...|.|
Zfish  3070 YQGLQQVLCDQLQAYTDACLSAGAPVHQWREPDFCPLV-CPPNSHYSICVSSCPETCLGINGPPG 3133

  Fly   306 CCPRCAVAEVRSECSLD-GIVYQNN---------------------ETWDMGPCR-SCRC-NGGT 346
            |..:|.     ..|..| |.:..:|                     |:|.:..|: .|.| .||:
Zfish  3134 CSEKCV-----EGCECDPGFILSDNKCVPVKDCGCVDSSGSYHPVDESWYLEGCKQKCTCEGGGS 3193

  Fly   347 IRCAQMRC-PAVKCRA--NEELKQPPGECCQRCVETAGTCTVFGDPHFRTFDGKFFSFQGSCKYL 408
            |:|....| |...|:.  .:.:.:|.|         :|.|:|.||||:.|||.|...|.|:|.|.
Zfish  3194 IKCYDTSCLPTESCQLQDGDYICKPLG---------SGICSVSGDPHYTTFDDKVHHFMGACSYT 3249

  Fly   409 LASDCMGKT----FHIRLTNEGR-GTRRASWAKTVTLSLRNLKVNLGQRMRVKVNGTRVTLPYFV 468
            |...|...:    |.:...||.| ..::.|:.::|.:.:.|..|.||:..:::|||.:||.|..:
Zfish  3250 LTKPCNETSGMPYFSVETQNEHRDNNKKVSYVRSVIVKVHNTTVILGKGRKIQVNGVQVTAPVTL 3314

  Fly   469 VAGGQNVTIERLANGGAVMLRSEMGLTLEWNGAGFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTG 533
            ..|     |:...:|..|:|.:..||.:.::|.....|::|:.:...||||||||||:..||...
Zfish  3315 SNG-----IKIFMSGKFVVLETNFGLRVRFDGNHHADVTLPSSYNGLLCGLCGNFNGNPNDDNIK 3374

  Fly   534 KDGRSHGDDEVWHFANSWKV----------GGPKSCSRKREFLAATPTCDKRKSNFYCHPLSVP- 587
            .||:.  .|.......||:|          ||...|..|.:..|..||.        |..::.|
Zfish  3375 LDGKP--TDSTNELGESWQVPDDRPDCTHGGGDIECDDKIQSEAQKPTS--------CGMITDPN 3429

  Fly   588 ALFGECNERLNPENYKAACRMDVCECPSGDCH---CDSFAAYAHECRRLGVQLPDWRSATNCP 647
            .:|..|:..:.|:.|...|..|  :|.:|...   |.:..:||..|.:.||.: :||:.|.||
Zfish  3430 GIFKPCHAVVPPDPYFENCVFD--QCGTGGAAVALCQAIQSYADLCAQAGVPI-NWRNNTFCP 3489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	18/92 (20%)
		VWC	256..310	CDD:278520	19/75 (25%)
		VWC	319..376	CDD:214564	18/83 (22%)
		VWD	371..536	CDD:214566	55/169 (33%)
		C8	580..646	CDD:285899	19/69 (28%)
zanl	NP_001352287.1	MAM	38..197	CDD:99706
		MAM	204..362	CDD:99706
		TIL	588..639	CDD:307783
		VWD	703..855	CDD:306577
		C8	892..967	CDD:214843
		TIL	970..1022	CDD:307783
		VWC	1024..1076	CDD:327433
		VWD	1083..1235	CDD:306577
		C8	1281..1349	CDD:214843
		TIL	1352..1405	CDD:307783
		VWC	1407..1460	CDD:327433
		TIL	1466..1517	CDD:307783
		VWD	1581..1733	CDD:306577
		C8	1770..1845	CDD:214843
		TIL	1848..1900	CDD:307783
		VWC	1902..1954	CDD:327433
		VWD	1961..2112	CDD:306577
		C8	2159..2227	CDD:214843
		TIL	2230..2283	CDD:307783
		VWC	2285..2338	CDD:327433
		TIL	2344..2395	CDD:307783
		VWD	2459..2611	CDD:306577
		C8	2648..2723	CDD:214843
		TIL	2726..2778	CDD:307783	5/20 (25%)
		VWC	2780..2832	CDD:327433	16/57 (28%)
		VWD	2839..2991	CDD:306577	28/157 (18%)
		C8	3037..3105	CDD:214843	17/67 (25%)
		TIL	3108..3161	CDD:307783	10/57 (18%)
		VWC	3163..3216	CDD:327433	12/52 (23%)
		VWD	3224..3378	CDD:306577	55/158 (35%)
		C8	3422..3488	CDD:312319	19/68 (28%)
		TIL	3492..3545	CDD:307783
		TILa	3547..3602	CDD:315397
		VWD	3609..3762	CDD:306577
		C8	3805..3874	CDD:214843
		TIL	3877..3932	CDD:307783
		VWC	3934..3988	CDD:327433
		VWD	3996..4150	CDD:306577
		C8	4214..4282	CDD:312319
		TIL	4286..4340	CDD:307783
		EGF_CA	4399..4433	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910