DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cv-2 and sspo

DIOPT Version :9

Sequence 1:	NP_524809.2	Gene:	cv-2 / 45280	FlyBaseID:	FBgn0000395	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_021325919.1	Gene:	sspo / 100036547	ZFINID:	ZDB-GENE-051114-1	Length:	5530	Species:	Danio rerio

Alignment Length:	639	Identity:	174/639 - (27%)
Similarity:	253/639 - (39%)	Gaps:	174/639 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 SGVRQSCSNEGEEVQLKNQPQIFTCFKCECQNGFVNCRDTCPPVNDCY----------------I 108
            |.|.|:|.:     .:..:|.:..|....|         :|.|...|:                :
Zfish   754 SNVFQACHD-----VVDREPFMRLCVSEVC---------SCGPQASCHCSVLTAYATHCAQEGAL 804

  Fly   109 LDKSNGTCCR-RCKGCSFRGMSYES-----GSE-------WN-DPEDPCKTYKCVATVVTETIQK 159
            |...|.|.|. :|.|    |..|:.     |:.       |: :|::..:.  ||:        .
Zfish   805 LSWRNHTFCPVQCSG----GQVYQECGRLCGTSCADLWDGWSCEPDEGSRV--CVS--------G 855

  Fly   160 CYSQCDNNQLQPPRPGECCPT--CQGCKINGQTVAEGHEVDASIDDRCLVCQCRGTQLTCSKKTC 222
            |  ||.:...|..: |:|.|.  |. || :|.|:   |...:||::.|..|.|......|:..:|
Zfish   856 C--QCPDGLAQDAQ-GQCVPVHMCP-CK-SGDTL---HPAGSSINNNCNTCVCARGVWNCTDLSC 912

  Fly   223 PVL-PCPMSKQIKRPDECCPRCPQNHSFL-----PVPGKCLFNKSVYPEKTQFMPDRCTNCTCLN 281
            |.| .||.| .|..|..|...|...:|.|     |:.| |     :.||.|..:.|:|.
Zfish   913 PELNQCPGS-LIFSPRSCLRTCSSPNSPLDACTEPIHG-C-----ICPEGTVLLGDQCV------ 964

  Fly   282 GTSVCQRPTCPILECAPEFQEPDGCCPRCAVAEVRSECSLDGIVYQNNETWDMGPCRSCRCNGGT 346
                                :||.|           .|..:|.:|..|:|... .|.:|.|....
Zfish   965 --------------------KPDEC-----------PCHHNGRLYFTNDTISK-DCNTCVCREQR 997

  Fly   347 IRCAQMRCPAVKCRANEELKQPPGECCQRCVETAGTCTVFGDPHFRTFDGKFFSFQGSCKYLLAS 411
            ..|.|..|                         :|||...||||:.||||:.:||.|.|:|:|..
Zfish   998 WHCGQALC-------------------------SGTCVATGDPHYITFDGRHYSFLGDCEYVLVQ 1037

  Fly   412 DCMGKTFHIRLTNEGRGTRRASWAKTVTLSLRNLKVNLGQRMRVKVNGTRVTLP--YFVVAGGQN 474
            :..| .|.:...|...|:...:..|:|||::.|..::|.:...|.|||..||||  |    .|..
Zfish  1038 ESSG-LFSVSAENVPCGSTGVTCTKSVTLTIGNTAIHLLRGKAVTVNGIPVTLPKSY----SGSG 1097

  Fly   475 VTIERLANGGAVMLRSEMGLTLEWNGAGFLQVSVPAKFKKRLCGLCGNFNGSSRDDLTGKDGRSH 539
            :.:||:  |..|.|.|.:|:||.|:|...:.|.:......|:.||||||:|.:.:|.|.:.|...
Zfish  1098 LILERV--GLFVSLSSRLGVTLLWDGGMRVYVRLMPHLHGRVGGLCGNFDGDAENDFTTRQGIME 1160

  Fly   540 GDDEVWHFANSWKVGGPKSCSRKREFLAATP--------TCDKRKSNFYCHPLSVPALFGECNER 596
            ...|:  |.||||:.  .||....:.....|        |..|:|    |..:: ..:|..|:..
Zfish  1161 STPEL--FGNSWKIS--PSCPDVADQDLRDPCFINPHRVTWAKKK----CAVIN-QEIFSSCHSE 1216

  Fly   597 LNPENYKAACRMDVCECPSG---DCHCDSFAAYAHECRRLGVQLPDWRSATNCP 647
            :..:.|...|..|.|.|.||   :|.|.:.||||.||.|.||.: .|||...||
Zfish  1217 VPYQQYYDWCVFDACGCDSGGDCECLCTAVAAYAEECNRRGVYV-RWRSQELCP 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv-2	NP_524809.2	VWC	184..243	CDD:214564	20/59 (34%)
		VWC	256..310	CDD:278520	9/53 (17%)
		VWC	319..376	CDD:214564	11/56 (20%)
		VWD	371..536	CDD:214566	59/166 (36%)
		C8	580..646	CDD:285899	24/68 (35%)
sspo	XP_021325919.1	VWD	190..342	CDD:214566
		C8	392..458	CDD:312319
		TIL	462..517	CDD:307783
		VWD	557..706	CDD:321964
		C8	745..814	CDD:214843	13/73 (18%)
		TIL	817..876	CDD:307783	16/75 (21%)
		VWD	1009..1157	CDD:306577	57/154 (37%)
		C8	1196..1269	CDD:214843	27/78 (35%)
		TIL	1272..1328	CDD:307783
		LDLa	1409..1439	CDD:197566
		LDLa	1445..1479	CDD:238060
		LDLa	1488..1524	CDD:238060
		LDLa	1528..1562	CDD:238060
		LDLa	1564..1598	CDD:238060
		LDLa	1603..1637	CDD:238060
		LDLa	1640..1673	CDD:197566
		LDLa	1687..1719	CDD:238060
		TSP1	1775..1821	CDD:214559
		TSP1	1827..1886	CDD:214559
		TIL	1885..1940	CDD:307783
		TSP1	1984..2037	CDD:214559
		FA58C	2144..2309	CDD:238014
		LDLa	2320..2357	CDD:238060
		FA58C	2400..2551	CDD:330301
		LDLa	2646..2680	CDD:238060
		LDLa	2702..2736	CDD:238060
		TSP1	2742..2791	CDD:214559
		TSP1	2796..2847	CDD:214559
		TIL	2875..2917	CDD:307783
		TSP1	2960..3009	CDD:214559
		TSP1	3019..3070	CDD:214559
		TSP1	3232..3283	CDD:214559
		TSP1	3288..3329	CDD:214559
		TIL	3335..3387	CDD:307783
		TSP1	3430..3482	CDD:214559
		TSP1	3487..3538	CDD:214559
		TIL	3548..3597	CDD:307783
		TSP1	3643..>3685	CDD:214559
		TSP1	3885..3936	CDD:214559
		TSP1	3942..3986	CDD:214559
		TSP1	4113..4165	CDD:214559
		TSP1	4184..4232	CDD:214559
		TSP1	4249..4301	CDD:214559
		TSP1	4307..4358	CDD:214559
		TIL	4363..4418	CDD:307783
		TSP1	4557..4608	CDD:214559
		TSP1	4614..4665	CDD:214559
		TIL	4719..4774	CDD:307783
		TSP1	4884..4933	CDD:214559
		TIL	4948..4993	CDD:307783
		TSP1	5037..5084	CDD:214559
		TSP1	5090..5139	CDD:214559
		TIL	5143..5197	CDD:307783
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910