DRSC/TRiP Functional Genomics Resources

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Protein Alignment csw and PTPRS

DIOPT Version :10

Sequence 1:NP_477131.1 Gene:csw / 45278 FlyBaseID:FBgn0000382 Length:945 Species:Drosophila melanogaster
Sequence 2:NP_002841.3 Gene:PTPRS / 5802 HGNCID:9681 Length:1948 Species:Homo sapiens


Alignment Length:649 Identity:157/649 - (24%)
Similarity:251/649 - (38%) Gaps:218/649 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   280 SELIDHYKRNPM--------VETCGTVVHLRQP-------FNATRITAAGINARVEQLVKGG--- 326
            ::|..|:.::|:        ....|....||:|       .:...|..|.:....|:|....   
Human  1328 ADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAEHTERLKANDSLK 1392

  Fly   327 FWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYI-- 389
            ..:|:||:  |....|:......:.|:.||||.|::.|||:||.|..:| .:.|::||||||:  
Human  1393 LSQEYESI--DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIE-GIMGSDYINANYVDG 1454

  Fly   390 ------------RLP-TDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNKTCVQC-- 439
                        .|| |.||.:.|.....|         |.....|       :|:.|:.::|  
Human  1455 YRCQNAYIATQGPLPETFGDFWRMVWEQRS---------ATIVMMT-------RLEEKSRIKCDQ 1503

  Fly   440 -----------AVKSAILPYSNCATCSRKSDSLSKHKRSES------------------------ 469
                       .::..:|.....||...::.||.|:..||.                        
Human  1504 YWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFL 1568

  Fly   470 ------SASSSPSSG-----SGSGPGSSGTSGV-----------SSVNGPGTPTNLTS------- 505
                  ...:.|.:|     ..:|.|.:|...|           .:|:..|..|.:.|       
Human  1569 AFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQ 1633

  Fly   506 -------------GTAGC-------------------------LVGL---LKRHSN--------- 520
                         ...||                         :.|:   .||.:|         
Human  1634 TEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFI 1698

  Fly   521 --------------------------------DSSGAVSISMAEREREREREMFKTYIATQGCLL 553
                                            :.|..::.|..:..|::     |.||||||.| 
Human  1699 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQ-----KAYIATQGPL- 1757

  Fly   554 TQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDY 618
               ..|..|||.|:|:.|:.::||.||..|.|:|||.:|||.| ||.::.:..:..::|.:...|
Human  1758 ---AETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAE-RSARYQYFVVDPMAEYNMPQY 1818

  Fly   619 TLREFLVS-WRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVH 682
            .||||.|: .||..:|.:..:.|..||:.|||......::|:..|:..:....|    .|||.||
Human  1819 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ----DGPISVH 1879

  Fly   683 CSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYI 746
            ||||:||||.||.:.::|:::...|:   :||.:|::|:|:||..:||||.:|:|.|.|...|:
Human  1880 CSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1940

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cswNP_477131.1 SH2_C-SH2_SHP_like 211..307 CDD:198185 7/41 (17%)
PTPc-N11_6 352..748 CDD:350392 141/559 (25%)
PTPRSNP_002841.3 I-set 33..124 CDD:400151
Ig strand B 50..54 CDD:409353
Ig strand C 63..67 CDD:409353
Important for binding to glycosaminoglycan chains. /evidence=ECO:0000250|UniProtKB:B0V2N1 68..72
Ig strand E 86..93 CDD:409353
Ig strand F 104..109 CDD:409353
Ig strand G 117..120 CDD:409353
IgI_2_RPTP_IIa_LAR_like 137..235 CDD:409400
Ig strand A' 143..147 CDD:409400
Ig strand B 150..159 CDD:409400
Ig strand C 164..170 CDD:409400
Ig strand C' 172..174 CDD:409400
Ig strand D 183..187 CDD:409400
Ig strand E 199..204 CDD:409400
Ig strand F 213..220 CDD:409400
Ig strand G 223..234 CDD:409400
IgI_3_RPTP_IIa_LAR_like 248..329 CDD:409401
Ig strand A 248..250 CDD:409401
Ig strand A' 254..258 CDD:409401
Ig strand B 261..269 CDD:409401
Ig strand C 274..280 CDD:409401
Ig strand C' 282..284 CDD:409401
Ig strand D 287..291 CDD:409401
Ig strand E 296..301 CDD:409401
Ig strand F 308..315 CDD:409401
FN3 318..>724 CDD:442628
Ig strand G 319..328 CDD:409401
FN3 <671..>981 CDD:442628
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 700..724
FN3 1037..>1097 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1311..1340 3/11 (27%)
R-PTPc-S-1 1370..1651 CDD:350473 59/299 (20%)
R-PTP-S-2 1653..1942 CDD:350475 89/305 (29%)
Blue background indicates that the domain is not in the aligned region.

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