Protein Alignment csw and PTPRN2

DIOPT Version :10

• Sequence 1: NP_477131.1
• Gene: csw / 45278
• FlyBaseID: FBgn0000382
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_001295197.1
• Gene: PTPRN2 / 5799
• HGNCID: 9677
• Length: 1038
• Species: Homo sapiens
• Alignment Length: 773
• Identity: 159/773 - (20%)
• Similarity: 234/773 - (30%)
• Gaps: 350/773 - (45%)

  Fly     9 KLSSSLGNVVNHKLQEKQVYNNNNINNNNNNTLNNNNAYNNQRNFEYERAIQAHYGSKGRRSEER 73
            |:|:::.||....:::..|.|.:.:...:.                 .:.:|...|||.
Human   580 KVSANVQNVTTEDVEKATVDNKDKLEETSG-----------------LKILQTGVGSKS------ 621

  Fly    74 ERSGKFKASKGRKAKVTPPTETPEAQEPACK----------------------NCMTHD---ELA 113
                        |.|..||   ...||.:.|                      .|:.|.   .|.
Human   622 ------------KLKFLPP---QAEQEDSTKFIALTLVSLACILGVLLASGLIYCLRHSSQHRLK 671

  Fly   114 QIIKGVA--KGADAQRNRDNRLQRR--RRPLSAQPSAAASASTSTESLHRLTPSPQASYPATPTS 174
            :.:.|:.  .||||........::|  .||.........|..:|..|.....|.|..|..::.:|
Human   672 EKLSGLGGDPGADATAAYQELCRQRMATRPPDRPEGPHTSRISSVSSQFSDGPIPSPSARSSASS 736

  Fly   175 WTATPPQFPAAFGGASCSNSTLSLLATMRVQLHGYTWFHGNLSGKEAEKLILERGKNGSFLVRES 239
            |:..|.|          ||..:|
Human   737 WSEEPVQ----------SNMDIS------------------------------------------ 749

  Fly   240 QSKPGDFVLSVRTDDKVTHVMIRWQDKKYDVGGGESFGTLSELIDHYKRNPMVETCGTVVHLRQP 304
               .|..:||...|                                              ||:
Human   750 ---TGHMILSYMED----------------------------------------------HLK-- 763

  Fly   305 FNATRITAAGINARVEQLVKGGFWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRV 369
             |..|:...              ||...:.|.:...:|   ...::||..|||...:|.|||:||
Human   764 -NKNRLEKE--------------WEALCAYQAEPNSSF---VAQREENVPKNRSLAVLTYDHSRV 810

  Fly   370 KLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNK 434
             ||..|:|.:.::||||:.|   .|.|               |..||
Human   811 -LLKAENSHSHSDYINASPI---MDHD---------------PRNPA------------------ 838

  Fly   435 TCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGVSSVNGPGT 499
                                                                             
Human   839 ----------------------------------------------------------------- 838

  Fly   500 PTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCLLTQQVNTVTDFW 564
                                                         ||||||.|..    ||.|||
Human   839 ---------------------------------------------YIATQGPLPA----TVADFW 854

  Fly   565 NMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENS-TSDYTLREF-LVSW 627
            .|||:....||||.|...|.|..:|..|||||| |..:....:..|||:. ..|:.:|.| |.:.
Human   855 QMVWESGCVVIVMLTPLAENGVRQCYHYWPDEG-SNLYHIYEVNLVSEHIWCEDFLVRSFYLKNL 918

  Fly   628 RDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGT 692
            :....|.:..:||..|.|.|||:....:|:|.:.||.     ...| :..||.||||.|.||:||
Human   919 QTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNK-----CYRG-RSCPIIVHCSDGAGRSGT 977

  Fly   693 FIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTLI 750
            :::|||:|:::.:..  .||||..|::.:|.||.|:|||:.|::|...||...:..::
Human   978 YVLIDMVLNKMAKGA--KEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAIL 1033

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	6/95 (6%)
		PTPc-N11_6	352..748	CDD:350392	105/397 (26%)
PTPRN2	NP_001295197.1	RESP18	98..>152	CDD:464394
		Receptor_IA-2	532..620	CDD:463293	8/56 (14%)
		R-PTP-N2	750..1032	CDD:350458	118/507 (23%)