Protein Alignment csw and PTPRM

DIOPT Version :10

• Sequence 1: NP_477131.1
• Gene: csw / 45278
• FlyBaseID: FBgn0000382
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: XP_016881383.2
• Gene: PTPRM / 5797
• HGNCID: 9675
• Length: 1532
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 141/570 - (24%)
• Similarity: 203/570 - (35%)
• Gaps: 229/570 - (40%)

  Fly   222 EKLILERGKN----GSF-----LVRESQSKPGDFVLSVRT-----------DDKV-THVMIRWQD 265
            :|...|:|.|    .||     |...|.|.|..|.:...|           |..| |.:::...|
Human   842 DKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTAILVPIND 906

  Fly   266 KKYDVGGGESFGTLSELIDHYKRNPMVETCGTVVHLRQPFNATRITAAGINARVEQLVKG----- 325
            :.:.:....|  :|.:...:.||.|          ...|:...::..|   .||..|::.
Human   907 ETHTMASDTS--SLVQSHTYKKREP----------ADVPYQTGQLHPA---IRVADLLQHITQMK 956

  Fly   326 -----GFWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYIN 385
                 ||.||:||..:.....:  :...|.|||:||||.||:.|||:||:|..:|.. ..::|||
Human   957 CAEGYGFKEEYESFFEGQSAPW--DSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGD-TNSDYIN 1018

  Fly   386 ANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNKTCVQCAVKSAILPYSN 450
            .|||    ||
Human  1019 GNYI----DG------------------------------------------------------- 1024

  Fly   451 CATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGVSSVNGPGTPTNLTSGTAGCLVGLL 515
                        .|:.:.
Human  1025 ------------YHRPNH----------------------------------------------- 1030

  Fly   516 KRHSNDSSGAVSISMAEREREREREMFKTYIATQGCLLTQQVNTVTDFWNMVWQENTRVIVMTTK 580
                                         ||||||    ....|:.|||.|||.|||..|:|.|.
Human  1031 -----------------------------YIATQG----PMQETIYDFWRMVWHENTASIIMVTN 1062

  Fly   581 EYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFL-----------------VSWR 628
            ..|.|:.||.:||||:  :|.:...::..:.....::|.:|.|.                 ||.|
Human  1063 LVEVGRVKCCKYWPDD--TEIYKDIKVTLIETELLAEYVIRTFAVEKGGAGGEANCSPSREVSQR 1125

  Fly   629 D-QPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGT 692
            . ...|.|..:||..|||||||.....:|.|::.|.::....|      ||:.||||||.||||.
Human  1126 GVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSA------GPLVVHCSAGAGRTGC 1184

  Fly   693 FIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAV 742
            |||||::||...|.|:   :||...::.:||:|..:||||.||.|::.|:
Human  1185 FIVIDIMLDMAEREGV---VDIYNCVRELRSRRVNMVQTEEQYVFIHDAI 1231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	22/105 (21%)
		PTPc-N11_6	352..748	CDD:350392	107/409 (26%)
PTPRM	XP_016881383.2	MAM	50..207	CDD:214533
		FN3	180..>663	CDD:442628
		ig	217..299	CDD:395002
		fn3	524..599	CDD:394996
		R-PTPc-M-1	947..1236	CDD:350481	116/450 (26%)
		R-PTPc-M-2	1322..1527	CDD:350483