Protein Alignment csw and PTPRC

DIOPT Version :10

• Sequence 1: NP_477131.1
• Gene: csw / 45278
• FlyBaseID: FBgn0000382
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_002829.3
• Gene: PTPRC / 5788
• HGNCID: 9666
• Length: 1306
• Species: Homo sapiens
• Alignment Length: 933
• Identity: 192/933 - (20%)
• Similarity: 305/933 - (32%)
• Gaps: 372/933 - (39%)

  Fly     5 KCLEKLSSSLGNVVNHKLQEKQVYNN-----NNINNNNNNTLNNNNAYNNQRNFEYERAIQAHYG 64
            |.:|..:....|:.........:::|     .|:...:....::...|||.:.....:.|:..:|
Human   326 KNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFG 390

  Fly    65 SKGR------RSEERERSGKFKASKGRKAKVT--PPTET--------PEAQEPAC----KNCMTH 109
            |.|.      |||           ...:..:|  ||..:        .:..|..|    ||.:.:
Human   391 SPGEPQIIFCRSE-----------AAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKY 444

  Fly   110 DELAQIIKGVAKG---------ADAQRNRDNRLQRRRRPLSAQPSAAASASTSTESLHRLTPSPQ 165
            |  .|.:|...|.         |..|||                .:||....:|:|
Human   445 D--LQNLKPYTKYVLSLHAYIIAKVQRN----------------GSAAMCHFTTKS--------- 482

  Fly   166 ASYPATPTS-WTATPPQFPAAFGGASCSNSTLSLLA--TMRVQLH-------GYTWFHGNLSGKE 220
                |.|:. |                 |.|:|:.:  :|.|:..       .:..:|  |..:.
Human   483 ----APPSQVW-----------------NMTVSMTSDNSMHVKCRPPRDRNGPHERYH--LEVEA 524

  Fly   221 AEKLIL-ERGKNGSFLVRESQ--------------SKPGD-FVLSVRTD---------------- 253
            ...|:. |..||..|.|::.|              ..||: |:|...|.
Human   525 GNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIV 589

  Fly   254 DKVTHVMIRWQDKKYDVGGGES--FGTLSELIDHYKRNPMVETCGTVVHLRQPFNATRITAAGIN 316
            ..:..:::.:  |.||:....|  .....||::......::..        :|.:|..:    :.
Human   590 TSIALLVVLY--KIYDLHKKRSCNLDEQQELVERDDEKQLMNV--------EPIHADIL----LE 640

  Fly   317 ARVEQLVKGG--FWEEFESLQQDSRDTFSR---NEGYKQENRLKNRYRNILPYDHTRVKLLDVEH 376
            ....::...|  |..||:|:.:    .||:   .|..|..|:.||||.:|||||:.||:|.:: :
Human   641 TYKRKIADEGRLFLAEFQSIPR----VFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEI-N 700

  Fly   377 SVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNKTCVQCAV 441
            ..||:.||||:||    ||
Human   701 GDAGSNYINASYI----DG---------------------------------------------- 715

  Fly   442 KSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGVSSVNGPGTPTNLTSG 506
                                                                             
Human   716 ----------------------------------------------------------------- 715

  Fly   507 TAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFK---TYIATQGCLLTQQVNTVTDFWNMVW 568
                                               ||   .|||.||    .:..||.|||.|:|
Human   716 -----------------------------------FKEPRKYIAAQG----PRDETVDDFWRMIW 741

  Fly   569 QENTRVIVMTTKEYERGKEKCARYWP--DEGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQP 631
            ::...||||.|:..|..:.|||.|||  :|| :..||...::........||.:::..:..:.:.
Human   742 EQKATVIVMVTRCEEGNRNKCAEYWPSMEEG-TRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEK 805

  Fly   632 A--RRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFI 694
            |  |.:.|..|..|||||||.||..:|...:.||...:..:      |||.||||||:|||||:|
Human   806 ATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS------GPIVVHCSAGVGRTGTYI 864

  Fly   695 VIDMILDQIVRNGLDTE--IDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTLIARKRAEE 757
            .||.:|:     ||:.|  :|:...:..:|.||..:||.||||..::.|:..|
Human   865 GIDAMLE-----GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEY------------ 912

  Fly   758 QSLQVGREYTNIKYTGEIGNDSQRSPLPPAISSISLVPSKTPLTPTSADLGTGMGLSMGVGMGVG 822
              .|.|....|:            |.|.|.:.::......:..:|..|:..............:|
Human   913 --NQFGETEVNL------------SELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIG 963

  Fly   823 NKHASKQQPPLPVVNCNNNNNGI 845
            |:..:|.:        |.|:|.|
Human   964 NQEENKSK--------NRNSNVI 978

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	21/129 (16%)
		PTPc-N11_6	352..748	CDD:350392	104/404 (26%)
PTPRC	NP_002829.3	PTP_N	7..32	CDD:403599
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..163
		PHA03255	81..>231	CDD:165513
		CD45	237..295	CDD:432641
		fn3	393..462	CDD:394996	15/81 (19%)
		FN3	485..565	CDD:238020	18/98 (18%)
		R-PTPc-C-1	707..907	CDD:350405	87/365 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	993..1014
		R-PTP-C-2	1017..1223	CDD:350406
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1261..1306