Protein Alignment csw and PTPN13

DIOPT Version :10

• Sequence 1: NP_477131.1
• Gene: csw / 45278
• FlyBaseID: FBgn0000382
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: XP_011530467.1
• Gene: PTPN13 / 5783
• HGNCID: 9646
• Length: 2507
• Species: Homo sapiens
• Alignment Length: 812
• Identity: 182/812 - (22%)
• Similarity: 267/812 - (32%)
• Gaps: 343/812 - (42%)

  Fly    93 TETPEAQEPACKNCMTHDELAQII-------KGVA---------------KGADAQ---RNRDNR 132
            |.|...:|.....|..||.|.|::       :.||               .|...|   ....||
Human  1890 TLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNR 1954

  Fly   133 ----------LQRRRRPLSAQPS---AAASASTSTE----------SLHRLTPS----------- 163
                      |:..|..|...||   :|.||..||:          |...|||:
Human  1955 ALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEI 2019

  Fly   164 -----------------------PQASYPATPTSWTATPPQFPAAF------------------- 186
                                   |:.|:|...::::..|....:..
Human  2020 NEISYPKGKCSTYQIKGSPNLTLPKGSFPNQSSNYSKCPNNSESYIQEDDIYDDSQEAEVIQSLL 2084

  Fly   187 ----------------GGASCSNSTLSL---LATMRVQ--------LHGYTWFHGNLSGKEAEKL 224
                            .|.||...||.:   |:..|.:        |..|......::|  .|:.
Human  2085 DVVDEEAQNLLNENNAAGYSCGPGTLKMNGKLSEERTEDTDCDGSPLPEYFTEATKMNG--CEEY 2147

  Fly   225 ILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQDKKY--------DVGGGESFGTLSE 281
            ..|:.|:.| |:::.|.|..|       ||::|     |.:.:.        |.....||.|..|
Human  2148 CEEKVKSES-LIQKPQEKKTD-------DDEIT-----WGNDELPIERTNHEDSDKDHSFLTNDE 2199

  Fly   282 LIDHYKRNPMVETCGTVVHLRQPFNATRITAAGINARVE----QLVKGGFWEEFESLQQDSRDTF 342
            |              .|:.:.:...:.:.|.|.:.:.:.    .|.:|...:|.|:| |:.:...
Human  2200 L--------------AVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENL-QELKPLD 2249

  Fly   343 SRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESL 407
            ....|..:|||.||||:||||||.|||.|.|      ...||||::|::|
Human  2250 QCLIGQTKENRRKNRYKNILPYDATRVPLGD------EGGYINASFIKIP--------------- 2293

  Fly   408 NSSVPSCPACTAAQTQRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSAS 472
                                                                             
Human  2294 ----------------------------------------------------------------- 2293

  Fly   473 SSPSSGSGSGPGSSGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAERERER 537
                                                   ||
Human  2294 ---------------------------------------VG------------------------ 2295

  Fly   538 EREMFKTYIATQGCLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPD-EGRSEQ 601
             :|.| .|||.||.|.|    ||.|||.|:|::.:.||.|.|:|.|..|.||.||||: .|::..
Human  2296 -KEEF-VYIACQGPLPT----TVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTM 2354

  Fly   602 FGH-ARIQCVSENSTSDYTLREF-LVSWRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNT 664
            ..: .|:..|.......:.:|.. |...:.:..|.|.|.:|..||||..|:.|..:|.|:..:
Human  2355 VSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYM-- 2417

  Fly   665 RQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLV 729
            |..|      :.|||..||||||||:||.|.||::|..|.:   |.:.||...::.:|.||.|:|
Human  2418 RHIH------RSGPIITHCSAGIGRSGTLICIDVVLGLISQ---DLDFDISDLVRCMRLQRHGMV 2473

  Fly   730 QTEAQYKFVYYAVQHYIQTLIARKRAEEQSLQ 761
            |||.||.|.|..:.:    ::.|.:|||:..|
Human  2474 QTEDQYIFCYQVILY----VLTRLQAEEEQKQ 2501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	20/103 (19%)
		PTPc-N11_6	352..748	CDD:350392	106/398 (27%)
PTPN13	XP_011530467.1	KIND	3..190	CDD:214801
		FERM_F1_PTPN13	571..666	CDD:340715
		B41	573..781	CDD:214604
		PH-like	777..877	CDD:473070
		PDZ1_PTPN13-like	1090..1181	CDD:467285
		PTN13_u3	1177..1367	CDD:465189
		PDZ2-PTPN13_FRMPD2-like	1365..1456	CDD:467254
		PDZ3_PTPN13_FRMPD2-like	1504..1593	CDD:467181
		PDZ4_PTPN13-like	1789..1873	CDD:467182
		PDZ5_PTPN13-like	1884..1970	CDD:467183	15/79 (19%)
		PTPc-N13	2257..2490	CDD:350445	107/402 (27%)