Protein Alignment csw and PTPN12

DIOPT Version :10

• Sequence 1: NP_477131.1
• Gene: csw / 45278
• FlyBaseID: FBgn0000382
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: XP_047276629.1
• Gene: PTPN12 / 5782
• HGNCID: 9645
• Length: 807
• Species: Homo sapiens
• Alignment Length: 638
• Identity: 139/638 - (21%)
• Similarity: 219/638 - (34%)
• Gaps: 268/638 - (42%)

  Fly   209 YTWFHGNL--SGKEAE-KLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQDKKYDV 270
            :||:|.::  :.:||| :.:||.||                            ..::|.:
Human     5 WTWWHASVIPATQEAEAQELLEPGK----------------------------PRLQWAE----- 36

  Fly   271 GGGESFGTLSELIDHYKRNPMVETCGTVVHLR-QPFNATRITAAGINARVEQLVKGGFWEEFESL 334
                    ::.|  |......|.:|     |: ...:|.|:.......|.|::
Human    37 --------IAPL--HSSLGNRVRSC-----LKTNKQSAVRLRRLSTKYRTEKI------------ 74

  Fly   335 QQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYN 399
                   :....|.|:||..||||::|||:||:||| |.::.....::|||||:|:
Human    75 -------YPTATGEKEENVKKNRYKDILPFDHSRVK-LTLKTPSQDSDYINANFIK--------- 122

  Fly   400 MSSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKH 464
                                                                             
Human   123 ----------------------------------------------------------------- 122

  Fly   465 KRSESSASSSPSSGSGSGPGSSGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSIS 529
                                        .|.||
Human   123 ----------------------------GVYGP-------------------------------- 127

  Fly   530 MAEREREREREMFKTYIATQGCLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWP 594
                         |.|:||||.|    .|||.|||.|:|:.|..:|||..:|:|.|::||.||||
Human   128 -------------KAYVATQGPL----ANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWP 175

  Fly   595 DEGRSE-QFGHARIQCVSENSTSDYTLREFLVSWRDQPARRIFHYHFQVWPDHGVPADPGCVLNF 658
            ..|... .|...:|.|..|.:.:||.:|..|:.:::: :||::.:|:..||||.||:....:|:.
Human   176 LYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNE-SRRLYQFHYVNWPDHDVPSSFDSILDM 239

  Fly   659 LQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRS 723
            :..:...|.|      :..|||:|||||.||||....||...:.:....:..|.::...||.:|:
Human   240 ISLMRKYQEH------EDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRT 298

  Fly   724 QRSGLVQTEAQYKFVYYAVQHYIQTLI-------ARKRAEEQSLQVGREYTNIKYTGEIGNDSQR 781
            ||...|||:.||:.|:.|:....:..:       |:|.|:..:     |.........|..:.|.
Human   299 QRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVN-----EINTENMVSSIEPEKQD 358

  Fly   782 SPLPPAISSISLVPSKTPLTPTSADLGTGMGLSMGVGMGVGNKHASKQQPPLP 834
            ||           |.|.|.|.:.              :..|:......|||.|
Human   359 SP-----------PPKPPRTRSC--------------LVEGDAKEEILQPPEP 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	15/99 (15%)
		PTPc-N11_6	352..748	CDD:350392	99/396 (25%)
PTPN12	XP_047276629.1	PTP_DSP_cys	60..325	CDD:475123	105/442 (24%)