DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment csw and PTPN11

DIOPT Version :9

Sequence 1:NP_477131.1 Gene:csw / 45278 FlyBaseID:FBgn0000382 Length:945 Species:Drosophila melanogaster
Sequence 2:NP_001317366.1 Gene:PTPN11 / 5781 HGNCID:9644 Length:597 Species:Homo sapiens


Alignment Length:718 Identity:288/718 - (40%)
Similarity:370/718 - (51%) Gaps:232/718 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   160 LTPSPQASYPATPTSWTATPPQFPAA---------------------FGGASCSNSTLSLLATMR 203
            ||.....|:.|.|:.  :.|..|..:                     :||...  :||:.|....
Human    21 LTRGVDGSFLARPSK--SNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKF--ATLAELVQYY 81

  Fly   204 VQLHGY-----------------------TWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGD 245
            ::.||.                       .||||:|||||||||:.|:||:||||||||||.|||
Human    82 MEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGD 146

  Fly   246 FVLSVRTDD----------KVTHVMIRWQDKKYDVGGGESFGTLSELIDHYKRNPMVETCGTVVH 300
            |||||||.|          ||||||||.|:.||||||||.|.:|::|::|||:||||||.|||:.
Human   147 FVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQ 211

  Fly   301 LRQPFNATRITAAGINARVEQL---------VKGGFWEEFESL-QQDSRDTFSRNEGYKQENRLK 355
            |:||.|.|||.||.|.:||.:|         ||.|||||||:| ||:.:..:||.||.:|||:.|
Human   212 LKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNK 276

  Fly   356 NRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAA 420
            |||:||||:|||||.|.|.:.:...::|||||.| :|                            
Human   277 NRYKNILPFDHTRVVLHDGDPNEPVSDYINANII-MP---------------------------- 312

  Fly   421 QTQRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGS 485
            :.:..|:|                                 ||.|                    
Human   313 EFETKCNN---------------------------------SKPK-------------------- 324

  Fly   486 SGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQG 550
                                                                     |:||||||
Human   325 ---------------------------------------------------------KSYIATQG 332

  Fly   551 CLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENST 615
            ||    .|||.|||.||:|||:|||||||||.||||.||.:|||||...:::|..|::.|.|::.
Human   333 CL----QNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAA 393

  Fly   616 SDYTLREFLVS------WRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGE 674
            .||||||..:|      .:....|.::.|||:.|||||||:|||.||:||::|:.:|..:..|  
Human   394 HDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDA-- 456

  Fly   675 KPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVY 739
              ||:.|||||||||||||||||:::|.|...|:|.:||:.:|||||||||||:|||||||:|:|
Human   457 --GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIY 519

  Fly   740 YAVQHYIQTLIARKRAEEQSLQVGREYTNIKYTGEIGNDSQRSPLPPAISSISLVPSKTPLTPTS 804
            .||||||:||..|...|::|.:.|.|||||||:........:|||||.          || ||..
Human   520 MAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPC----------TP-TPPC 573

  Fly   805 ADL 807
            |::
Human   574 AEM 576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cswNP_477131.1 SH2_C-SH2_SHP_like 211..307 CDD:198185 72/105 (69%)
PTPc 326..744 CDD:214550 163/424 (38%)
PTPc 543..743 CDD:238006 118/205 (58%)
PTPN11NP_001317366.1 SH2_N-SH2_SHP_like 5..103 CDD:198203 14/85 (16%)
SH2_C-SH2_SHP_like 111..218 CDD:198185 72/106 (68%)
PTPc-N11 272..528 CDD:350453 152/402 (38%)
Substrate binding. /evidence=ECO:0000250 463..469 5/5 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 552..575 9/33 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 246 1.000 Domainoid score I2173
eggNOG 1 0.900 - - E2759_KOG0790
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2122
Inparanoid 1 1.050 685 1.000 Inparanoid score I711
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52365
OrthoDB 1 1.010 - - D132255at33208
OrthoFinder 1 1.000 - - FOG0002703
OrthoInspector 1 1.000 - - otm40638
orthoMCL 1 0.900 - - OOG6_102716
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3129
SonicParanoid 1 1.000 - - X1404
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.770

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