DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment csw and PTP-ER

DIOPT Version :9

Sequence 1:	NP_477131.1	Gene:	csw / 45278	FlyBaseID:	FBgn0000382	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_726092.1	Gene:	PTP-ER / 37461	FlyBaseID:	FBgn0016641	Length:	1377	Species:	Drosophila melanogaster

Alignment Length:	1011	Identity:	186/1011 - (18%)
Similarity:	292/1011 - (28%)	Gaps:	444/1011 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LSSSLGNVVNHKLQEKQVYNNNNINNNNNNTLNNNNAYNNQRNFEYERAIQAHYGSKGRRSEERE 74
            |.||.||::|..|........:.:|:.::..|:...|    .....::..|:|.    ..|.:..
  Fly   544 LHSSCGNLMNSGLSHSNYSLGSILNSKSSCNLDAGTA----SQIRADQLPQSHL----LGSSQGS 600

  Fly    75 RSGKFKASKGRKAKVTPPTETPEAQEPACKNCMTHDELAQIIKGVAKGADAQRNRDNRLQRRRRP 139
            |.|.|: .:|....:|..|                        |....:....|...:||:::..
  Fly   601 RQGLFR-RRGSNHSITLKT------------------------GHTTTSCGDLNSMQQLQQQQAM 640

  Fly   140 LSAQPSAAASASTSTESLHRLTPSPQASYPATPTSWTATPPQFPAAFGGASCSNSTLSLLATMRV 204
            |||:.....:..|::      |.|...|....|     ||.:     |......|..||...|
  Fly   641 LSAEKYNRLNMRTNS------TGSGSGSGSNVP-----TPKR-----GLLERRGSNQSLTLNM-- 687

  Fly   205 QLHGYTWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQDKKYD 269
                     |::.|          |..|:.:......:|...|.|....::..|     |.|.:.
  Fly   688 ---------GSILG----------GAAGTEIQMTDIVQPKVTVCSCAAANQAPH-----QRKFFS 728

  Fly   270 VG-------------GGESFGTLSELIDHYKRNPMVETCGTVVHLRQPFNATRITAAGI--NARV 319
            ..             |...||:.|:|    :.||..::    |...|...|| .|.||.  |...
  Fly   729 TENLNSSKANSQKFFGQVCFGSASDL----QPNPQQDS----VREDQAIGAT-CTCAGTVRNIMT 784

  Fly   320 EQLVKGGFWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDH---TRVKLLDVEHSVAGA 381
            ..|......|||:......:...|.:....|.:.::..|    .:||   |...::: :..|.|:
  Fly   785 RPLSPQTTSEEFKIYLASIQMLQSASNPLNQFDLIRLNY----VFDHSYQTNRNIIE-QPPVLGS 844

  Fly   382 EYINANYIRLPTDGDLYNMSSSSESLNSS-----------VPSC--------------------- 414
               ||..:..||  |:...||....|.:|           :|..
  Fly   845 ---NARDVETPT--DMVPPSSEDSELLASYQTVVSRMAQPIPELKENEQKRIFRDLHKEFWDLPL 904

  Fly   415 -----PACTAAQTQRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSS 474
                 |....:||:.       :.||         |||..|....          ..||||
  Fly   905 NHQEKPMVFGSQTKN-------RYKT---------ILPNENSRVL----------LESESS---- 939

  Fly   475 PSSGSGSGPGSSGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKR-------------HSNDSSGAV 526
                                       .|||     |:|.:||             ::|...|..
  Fly   940 ---------------------------ELTS-----LLGEIKRTSSVTASEDLPYINANYIKGPD 972

  Fly   527 SISMAEREREREREMFKTYIATQGCLLTQQVNTVTDFWNMVWQENTRV----------------- 574
            .:|             |.|:||||.|    .||:.:||.|::|...|.
  Fly   973 YVS-------------KCYVATQGPL----PNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDR 1020

  Fly   575 ----------IVMTTKEYERGKEKCARYWPDE--------GRSEQF------------------- 602
                      |||.|...|..::|||.|:|.|        .:.|.|
  Fly  1021 EQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFV 1085

  Fly   603 -----------------GHARIQCVSENSTSD------------------------YTLREFLVS 626
                             .|..::.|......|                        |::|:.::.
  Fly  1086 PDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLL 1150

  Fly   627 W-------RDQPARRI--FHYHFQVWPDHGVPADPGCVLNFLQDV-------------------- 662
            :       .....::|  :||.:..||||..|.|    :|.|.|.
  Fly  1151 YCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRD----INTLLDTCLHVLNLGKCESEFDIYDDT 1211

  Fly   663 -NTRQSHLAQA-----------GEKPGPICVHCSAGIGRTGTFIVIDMILDQI------------ 703
             :.|.:|||..           ..:|.|: :||||||||||.|..|...:.|:
  Fly  1212 RSERNAHLAAQRLEIYQQDIFNAVQPLPV-IHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGML 1275

  Fly   704 -----------VRNGLDTE---------------------------------------IDIQRTI 718
                       ..|..|::                                       :|:...:
  Fly  1276 TKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIV 1340

  Fly   719 QMVRSQRSGLVQTEAQYKFVYYAVQHYIQTLIARKR 754
            ..:|.||.|:||...||:.::.|:..|::..:|.:|
  Fly  1341 CNLRLQRGGMVQNSEQYELIHRAICLYLKRTLALRR 1376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	19/108 (18%)
		PTPc	326..744	CDD:214550	119/668 (18%)
		PTPc	543..743	CDD:238006	75/397 (19%)
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	96/531 (18%)
PTP-ER	NP_726092.1	PTPc	917..1364	CDD:238006	95/530 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443566
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930