DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment csw and Pez

DIOPT Version :9

Sequence 1:	NP_477131.1	Gene:	csw / 45278	FlyBaseID:	FBgn0000382	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_001260127.1	Gene:	Pez / 33882	FlyBaseID:	FBgn0031799	Length:	1252	Species:	Drosophila melanogaster

Alignment Length:	954	Identity:	183/954 - (19%)
Similarity:	322/954 - (33%)	Gaps:	299/954 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 HKLQEKQVYNNNNINNN--------------------NNNTL-----------NNNNAYNNQRNF 53
            |..|::|:.....|::|                    :||.|           :|||..|::|..
  Fly   367 HMQQQQQIQQQQMISSNISLATSANQMLGQSSSCLDLSNNNLHSSSGMLHHGGSNNNNNNDERER 431

  Fly    54 ------------EYERAIQAHYGSKGRRSEERERSGKFKASKGRKAKVTPPTETPEAQEPACKNC 106
                        :||.|:|..|         |..|.:|  .....|...|........:|...|.
  Fly   432 LKAMLPTYRPAPDYETAVQLKY---------RTPSAEF--HNVALAMAAPGNAYYAGSQPDVHNP 485

  Fly   107 MTHDE-------LAQIIKGVAKGADAQRNRDNRLQRRRRPLS-AQPSAAASASTS-TESLHRL-- 160
            ..|:|       .|.....||:.|.|..:..|..|.:.:|.| .||.:.|.|... ::.:|.:
  Fly   486 GMHNENLLYGHMTAHRYPDVAQPAAALHHHINLYQAQHQPQSHPQPMSPAQAYLELSQRMHMMRH 550

  Fly   161 -TPSP---QASYPATPTSWTATP--------------------------PQFPAAFGGASCSNST 195
             .|.|   :.|..:||....|||                          .|:.|...|....|..
  Fly   551 KAPPPYVNRLSSSSTPDLAVATPRPLQGFRNYVSGSSPDLVSNRTLFNGGQYVALPAGGHAGNIP 615

  Fly   196 LSLLATMRVQLHGYTWF------------HG---NLSGKEAEKLILERGKN-----------GSF 234
            .|..|||   ||.|.:.            ||   ||:..|.:..|:.:.:.           ||.
  Fly   616 TSSGATM---LHQYQYVSHMGHSQPYLPPHGTFENLNMIEEQPSIMSQLRQSAMSQAAAAAAGSV 677

  Fly   235 LVRESQS-KPGDFVLSV-------------------RTDDKVTHVMIRWQ-DKKYD-------VG 271
            :.:.|.: .|..:..||                   .|...:...::... :..|:       ..
  Fly   678 VTQSSPTLPPSGYRSSVPPPASSPLPPPVVASSHKSATPAPLQRSLVNGSIEPIYENVPLPQRAS 742

  Fly   272 GGESFGTLSELIDHYKRNPMVETCGTVVHLRQPFNAT--RITAAGINARVEQLVKGGFWEEFESL 334
            ||.|....:|.:  .:|...:::...||.:....||:  .:....:|:..:.    |..:::.:.
  Fly   743 GGSSGAANTEAM--RQRASSIQSAPGVVPVPAARNASSNNVVTVTVNSPPDD----GNIKKYGAD 801

  Fly   335 QQDSRD-TFSRNEGYKQENRLKNRYRNI----LPYDHTRVKLLDVEHSV-----AG--------A 381
            :..|.: .|...:..|:.||..:...::    .|..|.....|:...:|     ||        |
  Fly   802 RAASTELLFLEPQAPKRTNRAASAAPDMGATPPPRQHRSTASLNKSSTVDMITPAGDTLQQQFSA 866

  Fly   382 EYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNKTCVQCAVKSAIL 446
            ..::||           ..:|:|...||::.:..:..|::..:........:::......|||.|
  Fly   867 MNLSAN-----------TSASTSSMFNSTLDTTSSSAASKDLKRKKRWNFLSRSKTPDKQKSATL 920

  Fly   447 PYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGVSSVNGPGTPTNLTSGTAGCL 511
            ......|..:.|...:|.|.::... :.|:..|            :.||.|...:...|....|.
  Fly   921 GREKATTAGQHSKLAAKLKLAQDDL-NLPNRWS------------TGVNKPQPISGRYSKDKLCQ 972

  Fly   512 V----------------------------GLLK---------------------------RHSND 521
            :                            .||:                           ||...
  Fly   973 ILDQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNRHGYV 1037

  Fly   522 SSGAVSISMAEREREREREMFKTYIATQGCLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGK 586
            ::.::|.::..::|        .||..|.   .|:..|:..||..||:.:..::|..|::..
  Fly  1038 NASSISATVGTKQR--------FYIVAQS---PQEPLTMRIFWQCVWEADVYLVVQLTEDMS--- 1088

  Fly   587 EKCARYWPDEGRSE-QFGHARIQCVSENSTSDYT---LREFLVSWRDQPARR---IFHYHFQVWP 644
                 |.|...... :||..::......:|...|   ||.:.|     |:||   :::..:..|.
  Fly  1089 -----YIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHV-----PSRRYRSVWYLQYADWA 1143

  Fly   645 DHGVPADPGCVLNFLQDVNTRQSHLAQAGEKP------GPICVHCSAGIGRTGTFIVIDMILDQI 703
            :...|.|....|:||:::|:  ..||...|.|      .|:.:||..|.||:|..:..|::|..:
  Fly  1144 EQNCPRDVNHFLDFLEELNS--VRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTL 1206

  Fly   704 VRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQ 747
            ..|   .::||.|.|..:|.||..::.:.|||||:|..:..|::
  Fly  1207 DHN---EDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK 1247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	21/149 (14%)
		PTPc	326..744	CDD:214550	98/503 (19%)
		PTPc	543..743	CDD:238006	57/212 (27%)
Pez	NP_001260127.1	B41	26..230	CDD:214604
		FERM_N	26..93	CDD:286467
		FERM_M	114..230	CDD:278785
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009
		Y_phosphatase	1007..1243	CDD:278528	61/264 (23%)
		PTPc	1009..1243	CDD:238006	61/262 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443539
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840