Protein Alignment csw and ptpn6

DIOPT Version :10

• Sequence 1: NP_477131.1
• Gene: csw / 45278
• FlyBaseID: FBgn0000382
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: XP_009290703.1
• Gene: ptpn6 / 335573
• ZFINID: ZDB-GENE-030131-7513
• Length: 590
• Species: Danio rerio
• Alignment Length: 692
• Identity: 241/692 - (34%)
• Similarity: 330/692 - (47%)
• Gaps: 232/692 - (33%)

  Fly   190 SCSNSTLSLLATMRVQLHGYTWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDD 254
            :||:.|     |.|       |:||:|||..||||:.||.:.|:||||||.|||||||||..|||
Zfish   102 NCSDPT-----TER-------WYHGHLSGPNAEKLLRERNEPGTFLVRESLSKPGDFVLSALTDD 154

  Fly   255 ------KVTHVMIRWQDKKYDVGGGESFGTLSELIDHYKRNPMVETCGTVVHLRQPFNATRITAA 313
                  :|:|:.|...:.:|.|||.:.|..|::|::|:||..:.|..||:|:|:||:.:||:.||
Zfish   155 QTSSGRRVSHIKIMCNNDRYTVGGKDQFDNLTDLVEHFKRVGIEELSGTMVYLKQPYYSTRLNAA 219

  Fly   314 GINARVEQL---------------VKGGFWEEFESLQQ-DSRDTFSRNEGYKQENRLKNRYRNIL 362
            .|.:||.||               :|.||||||::||: :::.|.||:||.:.||:.||||:|||
Zfish   220 DIQSRVNQLDQTSEREKMDGADKKIKAGFWEEFDALQKLETKVTKSRDEGMRPENKSKNRYKNIL 284

  Fly   363 PYDHTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCS 427
            |:|.|||.|.:.:.:|.|::||||||:
Zfish   285 PFDETRVILENADPNVVGSDYINANYV-------------------------------------- 311

  Fly   428 NCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGVS 492
                .||..|                                   ::|.
Zfish   312 ----INKLMV-----------------------------------TNPQ---------------- 321

  Fly   493 SVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCLLTQQV 557
                                                              |||||.||||.|
Zfish   322 --------------------------------------------------KTYIACQGCLAT--- 333

  Fly   558 NTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWP-DEGRSEQFGHARIQCVSENSTSDYTLR 621
             ||.|||.|:|||::|||||||:|.|:|:.||..||| .||.|::.|...::.:||...:||.:|
Zfish   334 -TVDDFWQMMWQEDSRVIVMTTREVEKGRNKCVPYWPTTEGESKEVGRYVVKLLSEMDAADYKVR 397

  Fly   622 --EFLVSWRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCS 684
              |.....|::..|:|:|:.:..|||||||.:||.||:||..||.:|..|..:    .||.:|||
Zfish   398 VVELSAPHRNEAPRKIWHFQYLSWPDHGVPQEPGGVLSFLDQVNRKQEELRSS----APIVIHCS 458

  Fly   685 AGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTL 749
            ||||||||.:||||::|.|...|||.:||||:.|.|||.||||:|||||||||:|.||..||::.
Zfish   459 AGIGRTGTIVVIDMLIDSIDAKGLDCDIDIQKCIMMVRDQRSGMVQTEAQYKFIYLAVLQYIEST 523

  Fly   750 IARKRAEEQSLQVGREYTNIKYTGEIGNDSQRSPLPPAISSISLVPSKTPLTPTSADLGTGMGLS 814
            ...:||   .::...||         ||.|.:|..|.|        |:...:..:.|:...:|..
Zfish   524 KVTRRA---IMETETEY---------GNLSIQSKHPKA--------SRKASSKKNEDVYENLGAK 568

  Fly   815 MGVGMGVGNKHASKQQPPLPVVNCNNNNNGIGNSGCSNGGGS 856
                   |.|...||:                 |....||||
Zfish   569 -------GKKDVKKQK-----------------SEEKKGGGS 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	51/101 (50%)
		PTPc-N11_6	352..748	CDD:350392	139/398 (35%)
ptpn6	XP_009290703.1	SH2_N-SH2_SHP_like	4..102	CDD:198203	241/692 (35%)
		SH2_C-SH2_SHP_like	110..213	CDD:198185	52/109 (48%)
		PTPc-N6	257..522	CDD:350454	145/415 (35%)