DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment csw and Ptpmeg2

DIOPT Version :9

Sequence 1:	NP_477131.1	Gene:	csw / 45278	FlyBaseID:	FBgn0000382	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_572576.1	Gene:	Ptpmeg2 / 31907	FlyBaseID:	FBgn0028341	Length:	827	Species:	Drosophila melanogaster

Alignment Length:	732	Identity:	165/732 - (22%)
Similarity:	236/732 - (32%)	Gaps:	326/732 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 ACKNCMTH--DELAQIIKGVAKG----------ADAQRNRDNRLQRRRRPLSAQPSAAASASTST 154
            :|:..||:  |||...|.||..|          |....|            ..:..||.:|:|..
  Fly   325 SCRQSMTNREDELLANIVGVGGGSGSGSAAGSAAIVSTN------------GTETEAATTAATII 377

  Fly   155 ESLHRL--------------TPSPQASYPATPTSWTATPPQFPAAFGG--------ASCSNSTLS 197
            .::|:|              .|:..||..||..:..||.|.......|        |:.|:|:.|
  Fly   378 SAVHQLGDNNTTVVTVSNGVGPAGSASGGATTAASAATEPNENITINGLSPSHRQAANNSSSSSS 442

  Fly   198 LLATMRVQLHGYTWFHGNLSGKEAEKLILERG--------------KNG---------------- 232
            ..||:...|      ..|.||.......:...              .||
  Fly   443 SAATVANPL------KLNTSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSSASSG 501

  Fly   233 -----SFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQDKKYDVGGGESFGTLSELIDHYKRNPMV 292
                 |...:|...||.|.::.          |::.:.:         .|.:.|..|...|.|.
  Fly   502 FSDDDSLAGQEGDPKPIDQIVQ----------MVKQRGR---------HGLIKEYADIRNRAPE- 546

  Fly   293 ETCGTVVHLRQPFNATRITAAGINARVEQLVKGGFWEEFESLQQDSRDTFSRNEGYKQENRLKNR 357
               ||.:|.|...|.|                                              |||
  Fly   547 ---GTFLHARMRANLT----------------------------------------------KNR 562

  Fly   358 YRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQT 422
            |.::|.|||:|| :|..|.....::|||||::    ||                         ..
  Fly   563 YTDVLCYDHSRV-VLAHEDGDEPSDYINANFV----DG-------------------------YK 597

  Fly   423 QRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSG 487
            |:|
  Fly   598 QKN-------------------------------------------------------------- 600

  Fly   488 TSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCL 552
                                                                    .||:|||.|
  Fly   601 --------------------------------------------------------AYISTQGPL 609

  Fly   553 LTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYW-PDEGRSEQFGHARIQCVSENSTS 616
                ..|..|||.|:|:::..||||||:..|||:.||.:|| |.|..|.:||...::.:|.....
  Fly   610 ----PKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNE 670

  Fly   617 DYTLREF-LVSWRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQ------AGE 674
            ||.:... |.:.:....|.:.|:.|..|||:|||:....:|||||.|..:|:.|.|      ||.
  Fly   671 DYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAMAMLNFLQKVREKQAQLVQGLGDTWAGH 735

  Fly   675 KPG-PICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFV 738
            ..| ||.||||||||||||||.:|:.:.::...|   ..||:.|::.:||||:..:|...||.|.
  Fly   736 PRGPPIVVHCSAGIGRTGTFITLDICISRLEDVG---TADIRGTVEKIRSQRAYSIQMPDQYVFC 797

  Fly   739 YYAVQHY------IQTL 749
            :.|:..|      :||:
  Fly   798 HLALIEYAYSRGMLQTV 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	20/130 (15%)
		PTPc	326..744	CDD:214550	106/426 (25%)
		PTPc	543..743	CDD:238006	85/208 (41%)
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:238099
		Y_phosphatase	557..803	CDD:278528	108/446 (24%)
		PTPc	559..803	CDD:238006	107/444 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443554
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840